Navigation Links
Isis Initiates Phase 1 Study in Patients With Cancer With the First Generation 2.5 Antisense Drug, ISIS-STAT3Rx
Date:3/7/2012

said Brett Monia, Ph.D., Senior Vice President, Drug Discovery and Corporate Development at Isis.  "We are very excited about the potential of our Generation 2.5 STAT3 drug to treat human cancers with high unmet medical needs as we continue to be the leader in antisense innovation. The advancement of our first drug incorporating our new, more potent Generation 2.5 chemistry is a key milestone and should allow us to further extend the reach of our technology into new targets, new tissues, and new disease opportunities."

ISIS-STAT3Rx is the first Generation 2.5 drug in Isis' pipeline. It is designed to treat cancer by inhibiting the production of STAT3, a gene that blocks natural cell death and that is critical for tumor cell growth and survival.  Inhibition of STAT3 has been shown to block the induction of tumor-associated cytokines involved in the progression of cancer, such as IL-6, IL-1, TGFβ, and IL-10, which could serve as important biomarkers in clinical studies.  Analyses of these cytokines in Phase 1 could serve as an early indicator of anticancer activity of ISIS-STAT3Rx in patients with cancer.

ABOUT ISIS PHARMACEUTICALS, INC.
Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners.  Isis' broad pipeline consists of 26 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic, severe and rare diseases, and cancer.  Isis' partner, Genzyme, plans to commercialize Isis' lead product, KYNAMRO, following regulatory approval, which is expected in 2012.  Isis' patents provide strong and extensive protection for its drugs and technology.  Additional information about Isis is available at www.isispharm.com.

ISIS PHARMACEUTICALS' FORWARD-LOOKING STATEMENT
This press release includes forward-looking statements regardin
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. EntreMed Initiates Plans for China Office
2. American Regent Initiates Nationwide Voluntary Recall of Phenylephrine HCl Injection, USP, 1%, 5 mL Vial, Lot# 0693, Due to Visible Particles
3. Echo Therapeutics Initiates Clinical Trials of its Symphony tCGM System in Critical Care Patients
4. Sangart Initiates Phase 1b Study of MP4CO in Patients With Sickle Cell Disease
5. Merrimack Pharmaceuticals Initiates Enrollment in Phase 1 Study of MM-151 in Patients with Refractory Advanced Solid Tumors
6. Sumagen Initiates Clinical Testing of Omnia Biologics Manufactured HIV Vaccine
7. Pfizer Initiates Phase 1 Clinical Trial for FVIIa Hemophilia Drug Candidate Developed by Catalyst Biosciences
8. Zimmer Initiates Quarterly Dividend and Announces New Share Repurchase Program
9. Isis Initiates Phase 1 Clinical Study of ISIS-SMNRx in Patients With Spinal Muscular Atrophy
10. Soligenix Initiates Next Generation Anthrax Vaccine Development Program Under Agreement With Harvard University
11. Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121 in Combination with Cetuximab and Irinotecan in Patients with Advanced Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... , Dec. 22, 2014   TRU-D SmartUVC ... UV disinfection robot, announced today that the General Services ... through November 2019.   This newly formed ... all levels of government purchasers, including Department of Veteran ... as Homeland Security contacts purchasing solutions for the Ebola ...
(Date:12/22/2014)... Inc. (NASDAQ: CYBX ), a global leader in ... announced it will participate in the 33 rd  Annual ... San Francisco . Dan ... at 11:00 AM Pacific Time.  A live audio webcast of ... Relations link on the Cyberonics home page at www.cyberonics.com ...
(Date:12/22/2014)... Maine , Dec. 22, 2014  Mark ... analysis brief providing a summary of the 2015 ... plan enrollment trends.  According to ... for Planning and Evaluation, Department of Health and ... were enrolled in individual medical plans through the ...
Breaking Medicine Technology:TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2Insights into the Marketplace and Individual Market Growth 2
... Inc. (NYSE: SMA ), a leading global ... surgical instruments, and sterilization cases and trays, announced today ... Olsen Medical. Olsen Medical is a privately-held, ... electrosurgical instruments and accessories. It manufactures a full line ...
... LOVELAND, Colo., Aug. 18, 2011 ... the "Company"), a provider of advanced veterinary diagnostic and ... retained Hayden IR, a national, New York-based investor relations ... raise its visibility and strengthen its relationships with the ...
Cached Medicine Technology:Symmetry Medical Closes Olsen Medical Acquisition 2Heska Retains Hayden IR to Develop Comprehensive Investor Relations Program 2Heska Retains Hayden IR to Develop Comprehensive Investor Relations Program 3
(Date:12/22/2014)... and state health officials are investigating a listeria outbreak ... four people and sickened 28 others in 10 states. ... caramel apples until more information becomes available, the U.S. ... news release. As of Dec. 18, a total ... strains of the bacteria Listeria monocytogenes . Of ...
(Date:12/22/2014)... 2014 Super Saturday, the last Saturday ... as the busiest day in the 2014 holiday shopping ... Station had a steady pre-Christmas stream of customers, ready ... Saturday. , “I definitely intend to take advantage…of the ... resident who was enjoying The Grass Station’s holiday sale ...
(Date:12/22/2014)... 22, 2014 In recognition of Veteran’s ... to Hero Reward, a local organization that provides services ... , Located on a couple hundred acres in ... offers lodging, world class fishing, hunting, hiking, horseback riding, ... founded several years ago to support U.S. Service men ...
(Date:12/22/2014)... December 22, 2014 7,178 small business ... of Black Friday shopping and opted instead to join ... education company, for their 5th annual “Black Friday Boot ... just $7 to attend the 5 hour online training ... promptly donated to support two Central Texas based charities ...
(Date:12/22/2014)... 2014 NAPW honors ... of the Year. Ms. Foley is recognized with this ... most-recognized networking organization of professional women in the country, ... of Professional Women is a powerfully vibrant networking community ... , “As a nurse, I felt like I made ...
Breaking Medicine News(10 mins):Health News:CDC Warns of Listeria Danger From Caramel Apples 2Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2
... ... Best in Class Alzheimer,s Care , ... Neenah, Wisc. (Vocus) October 14, 2009 -- Tracy Hoffman, M.D., one of the ... an industry innovator with 16 facilities in Wisconsin and Illinois. , , , , ,As ...
... In a ... supplement that targets many common chronic viruses. , ... Rochester, NY (PRWEB) October 14, 2009 -- Recently, polyDNA conducted a series ... the users of the supplement experience less sleeping problems, that is, better sleep relative to ...
... ... at Sheraton, Wakefield, MA, , ... Boston, MA (PRWEB) October 14, 2009 -- A.E. Schwartz & Associates ... Advanced Time Management, to be held Wednesday, November 18th at the Sheraton Wakefield, MA ...
... Director Dr. Merrill Matthews released the following statement: , ... (AHIP) daring to speak the truth about the Senate health ... anything AHIP,s analysis of health premium increases is too low. ... states, evidence of many of these proposed Senate and House ...
... 13 D. Porpoise Evans, a litigation associate in the ... has been named among the "40 Under 40" outstanding lawyers ... 40 lawyers will be honored at the CFF benefit dinner ... , "Porpoise,s recognition as one of Miami-Dade County,s top up-and-coming ...
... ... twice named one of America,s Top 100 heart hospitals, has been ranked No. 1 ... ... named one of America,s Top 100 heart hospitals, has been ranked No. 1 in ...
Cached Medicine News:Health News:Renowned Geriatrician Tracy Hoffman Tapped as Corporate Director of Memory Care Excellence By Fast-Growing CRL 2Health News:Renowned Geriatrician Tracy Hoffman Tapped as Corporate Director of Memory Care Excellence By Fast-Growing CRL 3Health News:Users of Gene-Eden, a Natural Antiviral, Report less Sleeping Problems in a Recent Study 2Health News:Users of Gene-Eden, a Natural Antiviral, Report less Sleeping Problems in a Recent Study 3Health News:One Day Management Training Program to be Offered November 18 in Boston Area 2Health News:One Day Management Training Program to be Offered November 18 in Boston Area 3Health News:One Day Management Training Program to be Offered November 18 in Boston Area 4Health News:One Day Management Training Program to be Offered November 18 in Boston Area 5Health News:AHIP Is Right, and May Be Low 2Health News:AHIP Is Right, and May Be Low 3Health News:Cystic Fibrosis Foundation Names Greenberg Traurig Attorney D. Porpoise Evans Among the '40 Under 40' Outstanding Lawyers of Miami-Dade County 2Health News:Holston Valley Ranks No. 1 in Tennessee for Cardiology 2
... RELISA ENA Multiparameter Kit is ... for six of the most ... a unique quality control system. ... Check) well in each strip ...
... RELISA ENA assays were designed with the ... clinician in the diagnosis of autoimmune disease. ... disease and 1,000 normal individuals were tested ... Test System. Immuno Concepts compared the results ...
... functional human C1q coated in the solid phase ... stage, CIC in the diluted patient samples and ... into the C1q coated assay wells. After incubation, ... and a ready to use conjugate (goat anti-human ...
... CIC are formed as a host ... cleared by phagocytosis. If not cleared, CIC ... inflammatory response. CIC are increased in Systemic ... may be involved in other autoimmune disorders ...
Medicine Products: