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Isis Initiates Phase 1 Studies with Isis-GCGRRx and Isis-GCCRRx to Treat Type 2 Diabetes
Date:11/2/2011

in patients with advanced diabetes.  Therefore ISIS-GCGRRx could work very well in those patients in whom most other therapies fail.  In our preclinical studies, which were conducted in the most insulin-resistant models of type 2 diabetes, antisense reduction of GCGR produced robust glucose control and resulted in preservation of the pancreas without producing hypoglycemia," said Sanjay Bhanot, M.D., Ph.D., Vice President, Metabolic Disorders and Translational Medicine of Isis.  "ISIS-GCGRRx has a significant effect in decreasing excessive liver glucagon action in these models.  In addition, it increased active GLP-1 thereby improving pancreatic function.  Due to this dual-action mechanism, ISIS-GCGRRx could be valuable for diabetic patients with severe hyperglycemia who are not controlled with current treatments."

Glucocorticoids are hormones that promote liver glucose production and fat storage.  Reduction of the glucocorticoid receptor (GCCR) action specifically in the liver and fat tissues is an attractive therapeutic approach, because it provides the desired effects on glucose and lipid control without causing potential side effects associated with systemic GCCR inhibition.  "In preclinical studies, we have demonstrated reduction of GCCR specific to the liver and fat with antisense drugs.  These preclinical results were accompanied by robust lowering of blood glucose and lipid levels and a decrease in body fat in obese animals.  Therefore ISIS-GCCRRx could be used in diabetic patients with moderate to severe hyperglycemia who are also obese and have high levels of lipids," concluded Dr. Bhanot.  

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners.  Isis' broad pipeline consists of 25 drugs to treat a wide variety of diseases with an emphasis on cardi
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SOURCE Isis Pharmaceuticals, Inc.
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