Navigation Links
Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference
Date:6/10/2008

- Oral presentation on the potent blood glucose lowering effect of SGLT2

antisense inhibitors in multiple preclinical models - Eight additional presentations highlight significant activity in eight

new metabolic disease targets utilizing antisense

SAN FRANCISCO and CARLSBAD, Calif., June 10 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today the presentation of new preclinical data showing that antisense drugs potently reduce levels of sodium dependent glucose transporter type 2 (SGLT2), a key component in controlling glucose re-absorption in the kidney and the target of ISIS 388626. In addition, Isis presented results from eight research programs on novel targets that offer new mechanisms to treat metabolic diseases. The nine presentations (including two late-breaking abstracts) were presented during the American Diabetes Association's (ADA) 68th Scientific Sessions in San Francisco by Isis and its collaborators.

"These data provide further evidence of the power of Isis' antisense technology to discover and develop highly potent and specific molecules targeted against many novel targets to treat a broad spectrum of metabolic diseases," said Robert R. Henry, M.D., Professor of Medicine, University of California at San Diego, and Chief, Section of Diabetes, Endocrinology, and Metabolism at VA San Diego Healthcare System.

The presentation titled "Long Term Safety and Efficacy of ISIS 388626, an Optimized SGLT2 Antisense Inhibitor, in Multiple Diabetic and Euglycemic Species," showed that antisense reduction of SGLT2 produced the following results in preclinical models:

-- Lowered HbA1c, a measure of average blood glucose over time in

d
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Uroplasty Highlights Clinical Results From a Study of the Urgent(R) PC Neuromodulation System
2. Memory Pharmaceuticals Highlights Progress with Key Programs at its R&D Day
3. Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Hepatitis C Data Presentations at Digestive Disease Week (DDW) Annual Meeting
4. Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data Presentations at European Association for the Study of the Liver (EASL) Annual Meeting
5. Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights
6. Sarasotas Roskamp Institute Highlights Positive Japanese Data that Validates its Ongoing Alzheimers Disease Research
7. Research Highlights Potential Benefits of Telemedicine in Treating Eye Disease
8. Synvista Therapeutics Highlights New Data Demonstrating the Clinical Benefit of Vitamin E Therapy in Patients Identified on the Basis of Haptoglobin Phenotype Testing
9. Schering-Plough Highlights PEGINTRON(TM) Clinical Data Presentations at the American Association for the Study of Liver Diseases (AASLD) 2007 Annual Meeting
10. Genaera Corporation Provides Highlights of Positive Phase 1 Trodusquemine (MSI-1436) Data from the North American Association for the Study of Obesity Annual Meeting
11. President Clinton Highlights MWW Group at the 2007 Clinton Global Initiative for its Stop Neglected Tropical Disease Campaign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 2014 Nektar Therapeutics (NASDAQ: ... positive results from its Phase 3 pivotal clinical ... recombinant factor VIII (rFVIII) treatment for hemophilia A ... its primary endpoint in reducing annualized bleed rates ... on-demand arm. Top-line results from the ...
(Date:8/21/2014)... Texas , Aug. 21, 2014  eRelevance ... services company, announced today that it has completed ... (EMR) solution for Plastic Surgery and Dermatology practices. ... even more value to healthcare practices using Nextech," ... of eRelevance Corporation. "Using information from the EMR ...
(Date:8/21/2014)... , Aug. 21, 2014 The spinal column is ... human body. Signals carried to and from the brain through ... and nervous system. Injury or ailment here can be life ... a loss of control over their body. Though back injury ... person,s life, there are more options available to make things ...
Breaking Medicine Technology:Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2
... BIOSAFE, Inc. , a company that manufactures and ... are launching in specific markets outside the United States ... Crosstex, new BIOSAFE-treated Ultra Sensitive facemasks begin to ... upon contact, and have further proven to be effective ...
... Shire plc (LSE: SHP,NASDAQ: SHPGY ), the ... pending litigation with Sandoz, Inc. ("Sandoz") in,connection with Sandoz,s ... generic versions of Shire,s ADDERALL XR(R) (mixed,amphetamine salts) for ... The settlement also provides Sandoz with a ...
Cached Medicine Technology:BIOSAFE Launching In a New Specially-Treated Facemask Effective Against H1N1 Influenza 2BIOSAFE Launching In a New Specially-Treated Facemask Effective Against H1N1 Influenza 3BIOSAFE Launching In a New Specially-Treated Facemask Effective Against H1N1 Influenza 4Shire and Sandoz Settle all Pending Litigation Concerning ADDERALL XR(R) 2Shire and Sandoz Settle all Pending Litigation Concerning ADDERALL XR(R) 3
(Date:8/21/2014)... August 21, 2014 The results of ... in The Journal of the American Medical Association (JAMA) ... cancers and reduces unnecessary recalls. Memorial Healthcare System was ... study. , “This study confirms what we already know ... cancers we want to find and, at the same ...
(Date:8/21/2014)... According to a new market report published ... - Home Theatre in-a-box, Home audio systems, Home radios, ... Size, Share, Growth, Trends and Forecast, 2013 - 2019,” ... 2012 and is expected to reach USD 20.68 billion ... 2013 to 2019. Europe was the largest contributor to ...
(Date:8/21/2014)... Aug. 21, 2014 (HealthDay News) -- In a new ... pregnant women avoid eating tuna due to concerns about ... which is second only to shrimp as the most ... pregnant women to avoid all tuna," Jean Halloran, director ... division of Consumer Reports, said in a news release ...
(Date:8/21/2014)... 21, 2014 Pleio, Inc., a ... launching a new suite of services for retail ... retail pharmacy by applying proven behavior shaping programs ... in increased medication adherence, higher PDC scores and ... Pleio’s PDC-targeted offerings align retail’s desire to meet ...
(Date:8/21/2014)... scientific collaboration led by Baylor College of Medicine has ... a rare form of kidney cancer, providing new insights ... as well. , The collaboration, a project of the ... , completed the sequence of chromophobe renal cell carcinoma ... Cancer Cell . , "The Cancer Genome Atlas ...
Breaking Medicine News(10 mins):Health News:Dr. Mary Hayes: Study Shows 3D Mammography Finds More Invasive Cancers While Reducing Unnecessary Recalls 2Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 2Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 3Health News:Consumer Reports Advises Pregnant Women to Avoid Tuna 2Health News:Pleio, Inc. Expands Adherence Offerings For Retail Pharmacy 2Health News:Sequence of rare kidney cancer reveals unique alterations involving telomerase 2Health News:Sequence of rare kidney cancer reveals unique alterations involving telomerase 3
... are main barriers to adoption , , , WEDNESDAY, March 25 ... the United States have comprehensive electronic health record systems currently ... to adopting such systems are costs, which can run as ... of doctors to change their ways, experts say. , "President ...
... Group Led by Former Rep. Gephardt Underscores Importance ... Cures for Life-Threatening Diseases , WASHINGTON, March 25 ... President Obama on his support for improving our ... through continued scientific and technological advancements. (Logo: ...
... The US Department of Homeland Security, Federal Emergency ... Bureau Veritas North America for a period of six ... units (THUs) in Louisiana and Mississippi. FEMA exercised its ... continue to provide formaldehyde sampling services for temporary housing ...
... treatments prevents Honolulu residents from ... March 25 Taking Control of Your Diabetes (TCOYD) ... national research firm Yankelovich that found that although Honolulu ... educated about diabetes management than the majority of their ...
... new era of treatment to save tiniest babiesCLEVELAND, March 25 , ... provides individual rooms with sleep accommodations so parents can stay with their ... Innovative care design that creates a healing environment with natural materials ... building materials incorporated throughout NICU. , ...
... The Christopher & Dana Reeve Foundation, the national, ... spinal cord injuries and improving the lives of people ... Representatives for passing the Christopher and Dana Reeve Paralysis ... Public Land Management Act. The legislation was named for ...
Cached Medicine News:Health News:Few Hospitals Embracing Electronic Health Record Systems 2Health News:Few Hospitals Embracing Electronic Health Record Systems 3Health News:Few Hospitals Embracing Electronic Health Record Systems 4Health News:Council for American Medical Innovation Applauds President Obama for Calling for 'Serious Investments in Science and Technology' 2Health News:FEMA Extends Formaldehyde Testing Contract with Bureau Veritas 2Health News:Survey Reveals Honolulu Residents Perceive Financial Challenges as Main Barrier in Properly Managing Their Type 2 Diabetes 2Health News:Survey Reveals Honolulu Residents Perceive Financial Challenges as Main Barrier in Properly Managing Their Type 2 Diabetes 3Health News:Survey Reveals Honolulu Residents Perceive Financial Challenges as Main Barrier in Properly Managing Their Type 2 Diabetes 4Health News:Rainbow Babies & Children's Hospital Opens Most Technologically Advanced NICU in World 2Health News:Rainbow Babies & Children's Hospital Opens Most Technologically Advanced NICU in World 3Health News:Rainbow Babies & Children's Hospital Opens Most Technologically Advanced NICU in World 4Health News:Christopher & Dana Reeve Foundation Applauds Historic Passage of the Christopher and Dana Reeve Paralysis Act 2Health News:Christopher & Dana Reeve Foundation Applauds Historic Passage of the Christopher and Dana Reeve Paralysis Act 3
... Bird and Cronin, ... manufacturer of Patient Footwear, ... Patient Care Products. Our ... highest quality and available ...
Foam Cervical Collar is medium-firm density. Breathable. Deeply anatomically contoured. Natural color, 100% cotton stockinette-covered for comfort. 2" hook and loop closures are another mark of quali...
Exo-Deluxe Overhead Traction for hospital or home care. Twice the clearance of other units between the patient and supporting wall. 2" nylon pulleys with polypropylene cord, head halter, spreader bar...
Wonderflex™ is a lined soft durometer silicone gel sheet. It is ideal for cushioning orthotic/prosthetic devices and offers protection from shock and sheer forces. Wonderflex can also be lamina...
Medicine Products: