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Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions
Date:6/9/2009

. Booten, K. Chakravarty, T. Zanardi, S. Henry, L.M. Watts, E.V. Wancewicz, A. Siwkowski, B.P. Monia. Antisense Reduction of FGFR4 Gene Expression Lowers Body Weight and Adiposity and Improves Insulin Sensitivity in Rodents (Oral Presentation) Authors: X.X. Yu, L.M. Watts, P. Manchem, S.L. Booten, B.P. Monia, S. Bhanot. Antisense Inhibition of cAMP Response Element Binding Protein (CREB) Expression Lowers Plasma Glucose and Lipids in Diabetic Rodents (Oral Presentation) Authors: S.F. Murray, S.L. Booten, L.M. Watts, B.P. Monia, S. Bhanot. A Newly Identified Role of Nuclear Receptor Corepressor, SMRT (Silencing Mediator of Retinoid and Thyroid) in Improving Hyperglycemia and Insulin Sensitivity in Obese and Diabetic Mice (Late-Breaking Poster) Authors: S.K. Pandey, S.F. Murray, S. Guo, L.M. Watts, S.L. Booten, A. Siwkowski, D. Witchell, P. Manchem, S. Bhanot, B.P. Monia. Inhibition of Transthyretin Expression by Antisense Oligonucleotides Lowers RBP4 Levels, Improves Insulin Sensitivity and Increases Heart Glucose Uptake in Diet-Induced Obese Mice (Late-Breaking Poster) Authors: P. Manchem, S.F. Murray, S.L. Booten, X.X. Yu, L.M. Watts, B.P. Monia, S. Bhanot. Antisense Reduction of RBP4 Expression Causes a Marked Improvement in Hepatic and Peripheral Insulin Sensitivity and Improves Cardiac Glucose Uptake in Diet-Induced Obese Mice Authors: P. Manchem, X.X. Yu, S.L. Booten, L.M. Watts, S.F. Murray, B.P. Monia, S. Bhanot. Knockdown of Carbohydrate Response Element Binding Protein (ChREBP) in Liver Protects Against Fructose Induced Hyperlipidemia and Insulin Resistance Authors: D.M. Erion, J.J. Hsiao, S. Yonemitsu, R. Stark, J. Dong, Y. Nagai, T. May, M. Kahn, X.X. Yu, S.F. Murray, S. Bhanot, B.P. Monia, G.W. Cline, V.T. Samuel, G.I. Shulman. Matrix Metalloproteinase-9: Association With Insulin Resistan
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SOURCE Isis Pharmaceuticals, Inc.
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