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Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions
Date:6/9/2009

ion of fibroblast growth factor receptor 4 (FGFR4) lowered adiposity and improved insulin sensitivity in mice, indicating that FGFR4 plays a role in the regulation of energy expenditure and adiposity. Selective inhibition of FGFR4 with antisense drugs in peripheral tissues could be a unique therapeutic approach for the treatment of obesity and related metabolic disorders.

"We are looking forward to expanding our metabolic disease pipeline by adding antisense drugs to treat obesity, an area with great unmet need where our peripherally acting drugs could have significant therapeutic utility without the potential for central nervous system toxicities that plague many centrally acting anti-obesity drugs," continued Dr. Bhanot. "Obesity is just one example of the many therapeutic areas that are amendable to our antisense drug discovery efforts. We continue to expand our discovery efforts and broaden our drug pipeline to address new diseases within our core therapeutic programs in cardiovascular, metabolic and severe neurodegenerative diseases and cancer."

Including presentations highlighting SGLT2 and FGFR4, Isis and its collaborators presented a total of eight presentations (including three oral talks and two late-breaking posters) at this year's ADA conference. The additional presentations highlighted antisense inhibitors to a number of metabolic targets in a variety of animal species that reduced mRNA target levels in specific tissues and provided therapeutic benefit such as improved insulin sensitivity, reduced fat mass and body weight in various models of disease. Complete abstracts for the presentations can be found on the ADA Web site at www.diabetes.org.

    ISIS 388626, an SGLT2 Antisense Drug, Causes Robust and Sustained
    Glucosuria in Multiple Species and Is Safe and Well-Tolerated (Oral
    Presentation)
    Authors: S. Bhanot, S.F. Murray, S.L
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SOURCE Isis Pharmaceuticals, Inc.
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