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Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity From Its Broad Metabolic Disease Franchise at ADA Scientific Sessions
Date:6/29/2010

, S. Bhanot, G. I. Shulman, R. G. Kibbey.

ISIS' METABOLIC FRANCHISE

Isis is pursuing the discovery and development of antisense drugs to treat metabolic diseases, such as diabetes and obesity.  According to the Centers for Disease Control and Prevention, diabetes affects more than 20 million people in the U.S.  Isis has four drugs in its pipeline to treat type 2 diabetes, each of which acts upon targets in the liver, fat tissue or the kidney through distinct mechanisms to improve insulin sensitivity, reduce glucose production, or affect other metabolic aspects of metabolic disease.  Isis is developing other drugs aimed at other types of metabolic diseases, including obesity where a peripherally acting anti-obesity drug could provide a unique therapeutic approach for the treatment of obesity and related metabolic disorders.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners.  The Company has successfully commercialized the world's first antisense drug and has 22 drugs in development.  Isis' drug development programs are focused on treating cardiovascular, metabolic and severe neurodegenerative diseases and cancer.  Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases.  Isis and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microRNA therapeutics.  Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are commercializing.  As an innovator in RNA-based drug discovery and development, Isis is the owner or ex
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SOURCE Isis Pharmaceuticals, Inc.
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