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Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity From Its Broad Metabolic Disease Franchise at ADA Scientific Sessions
Date:6/29/2010

in peripheral tissues, such as fat and liver, and not in the central nervous system could provide significant therapeutic benefit without the side effects that are associated with CNS-acting agents.  We look forward to moving a drug into our development pipeline soon," concluded Dr. Bhanot.  

In total Isis' antisense drugs were highlighted in seven presentations, including three oral and four poster presentations.  In addition to the oral presentations on ISIS 113715 and ISIS-GCGRRx, Isis and collaborators highlighted data from antisense inhibitors to a number of metabolic targets in a variety of animal models showing that antisense inhibition provided therapeutic benefit including reductions in fat mass and body weight and improved glucose metabolism.  Complete abstracts for the presentations can be found on the ADA Web site at www.diabetes.org.

ISIS 113715, a Novel PTP-1B Antisense Inhibitor, Improves Glycemic Control and Dyslipidemia and Increases Adiponectin Levels in T2DM Subjects Uncontrolled on Stable Sulfonylurea Therapy (Oral Presentation)

Authors: T. A. Brandt, S. T. Crooke, E. J. Ackermann, S. Xia, E. S. Morgan, Q. Liu, R. S. Geary, S. Bhanot.

First Proof of Pharmacology of a Novel Glucagon Receptor Antisense Drug in Humans (Oral Presentation)

Authors: E. S. Morgan, T. A. Brandt, M. G. J. Van Dongen, '/>"/>

SOURCE Isis Pharmaceuticals, Inc.
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