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Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity From Its Broad Metabolic Disease Franchise at ADA Scientific Sessions
Date:6/29/2010

nt adverse events or observations of hypoglycemia. The most common adverse event was mild injection site reactions.  

"We have demonstrated that our PTP-1B inhibitor has a very attractive profile in two Phase 2 studies in patients with type 2 diabetes.  A novel insulin sensitizer that reduces high blood glucose without resulting in hypoglycemia, reduces LDL-cholesterol and decreases weight would be a significant advance in the treatment of type 2 diabetes," said Sanjay Bhanot, M.D., Ph.D., Vice President of Metabolics and Translational Medicine at Isis.  "In this study, we observed reductions in multiple measures of glucose control that were consistent with our expectations for a 13-week study. We believe that with longer-term treatment we should also see reductions in longer-term measures of glucose control.  We are excited to continue to move this program forward and to evaluate PTP-1B inhibition in longer studies in combination with other commonly prescribed type 2 diabetes drugs."

In the oral presentation titled "First Proof of Pharmacology of a Novel Glucagon Receptor Antisense Drug in Humans," Dr. Bhanot presented the results of a Phase 1 study on ISIS-GCGRRx. The study, which included a glucagon challenge that doubled both plasma glucagon and glucose levels, produced the following results:

  • Statistically significant improvement in blood glucose levels and reduced liver glucose production following the glucagon challenge at a dose of 400 mg/week
  • No clinically significant adverse events or observations of hypoglycemia. The most common adverse event was mild injection site reactions.  

"In our Phase 1 study of ISIS-GCGRRx we achieved reductions in blood glucose following a glucagon challenge.  This re
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SOURCE Isis Pharmaceuticals, Inc.
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