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Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity From Its Broad Metabolic Disease Franchise at ADA Scientific Sessions
Date:6/29/2010

ORLANDO, Fla. and CARLSBAD, Calif., June 29 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that data from seven programs in Isis' broad metabolic disease franchise were presented at the American Diabetes Association's (ADA) 70th Scientific Sessions in Orlando.  These presentations included two oral talks highlighting data from Isis' Phase 2 study of ISIS 113715 in patients with type 2 diabetes and Isis' Phase 1 study of ISIS-GCGRRx. Isis and collaborators also presented new data from five other programs demonstrating that antisense drugs can approach novel targets to treat metabolic diseases and may provide new therapeutic options for patients.  

In the oral presentation titled "ISIS 113715, a Novel PTP-1B Antisense Inhibitor, Improves Glycemic Control and Dyslipidemia and Increases Adiponectin Levels in T2DM Subjects Uncontrolled on Stable Sulfonylurea Therapy," Dr. Sanjay Bhanot presented the results of a Phase 2 study evaluating ISIS 113715 in patients with type 2 diabetes whose glucose levels were uncontrolled despite being treated with maximum doses of sulfonylureas.  The study produced the following results:

  • Statistically significant reductions in multiple short and intermediate measures of glucose control at the 200 mg/week dose
  • Statistically significant decrease of approximately 11 mg/dL in LDL Cholesterol
  • Reduction in body weight that was preceded by a statistically significant increase in circulating adiponectin, supporting the role of PTP-1B in the regulation of body weight
  • No clinically significa
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SOURCE Isis Pharmaceuticals, Inc.
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