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Isis Adds Three New Drugs to Its Development Pipeline
Date:12/14/2011

ents.   In preclinical studies, antisense inhibition of Factor VII rapidly reduced Factor VII activity by more than 90 percent in three days, suggesting that ISIS-FVIIRx­ has the potential to be used in acute clinical settings, such as following surgery, in which patients are at high risk for developing blood clots.  ISIS-FVIIRx is the second drug to enter development as part of Isis' strategy to create more potent and safer anti-thrombotic drugs that do not increase bleeding. 

Conference Call

At 12:00 p.m. Eastern Standard Time Thursday, December 15, Isis will conduct a live webcast conference call to discuss these three new development candidates and ISIS-AATRx, which was added to Isis' pipeline this quarter.  Interested parties may listen to the call by dialing 866-825-3308 and refer to passcode 'Isis2011', or access the webcast at www.isispharm.com.  A webcast replay will be available for a limited time at the same address.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners.  Isis' broad pipeline consists of 28 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic and severe and rare/neurodegenerative diseases, and cancer.  Isis' partner, Genzyme, plans to commercialize Isis' lead product, mipomersen, following regulatory approval, which is expected in 2012.  Isis' patents provide strong and extensive protection for its drugs and technology.  Additional information about Isis is available at www.isispharm.com.

ISIS PHARMACEUTICALS' FORWARD-LOOKING STATEMENT

This press release includes forward-looking statements regarding the discovery, development, activity, therapeutic potential and safety of ISIS-APOA
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SOURCE Isis Pharmaceuticals, Inc.
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