Navigation Links
Ipsogen Reports Incorporation of the Genomic Grade in the 2009 St. Gallen International Consensus Meeting on the Primary Treatment of Early Breast Cancer
Date:7/9/2009

MARSEILLE, France, July 10 /PRNewswire-FirstCall/ -- Ipsogen SA (Alternext: ALIPS) today reported that the St. Gallen International Consensus Panel on the Primary Therapy of Early Breast Cancer indicated for the first time that the Genomic Grade could be considered as an adjunct to the histological grade. These new guidelines, published online in Annals of Oncology, represent the consensus opinion of 43 European and US experts on early breast cancer treatment that emerged from the conference which took place in March 2009.

According to the guidelines, histological grade 2 is considered as "not useful for chemo-endocrine-therapy decision" as compared to the established decision making value of histological grades 1 or 3. The panel also stated that the dominant prognostic information is provided by proliferation.

MapQuantTM Genomic Grade is available to European oncologists and pathologists. The genomic grade test analyzes a set of 97 genes to precisely quantify the proliferation potential of the tumor, and has been validated in several studies, covering more than 2 800 tumor samples. MapQuantTM Genomic Grade contributes to high-quality phenotyping of breast cancer, by resolving 80% of histological grade 2 tumors in genomic grade 1 or 3 of similar long term outcome as histological grades 1 and 3.

"The St Gallen Consensus Panel decision to identify the genomic grade as a valuable adjunct in the pathological characterisation of breast cancer legitimates Ipsogen strategy to provide pathologists and oncologists with state of the art molecular tests generating critical information for treatment decisions" said Helene Peyro-Saint-Paul, Chief Medical Officer, Ipsogen. "These new recommendations are going to support our regulatory and reimbursement efforts, a critical step to make our assay widely available to patients and pathologists/physicians," added Vincent Fert, Chief Executive Officer, Ipsogen.

"Treatment decision in a number of ER+ HER2- tumors remains a daily challenge", said Dr Fabrice Andre, Institut Gustave Roussy, France. "With these new St Gallen recommendations, pathologists and clinicians will be encouraged to move one step forward and to progressively incorporate molecular assays in their clinical practice in order to resolve these equivocal cases and tailor their treatment strategy for each individual patient."

About tumoral grade

Tumoral grade is a pivotal phenotypical feature of invasive breast cancer, which contributes to long term patient prognosis. European and US guidelines consider tumoral grade as one of the most important drivers in treatment decision, and several carefully validated and widely used treatment decision algorithms, such as the Nottingham Prognostic Index (NPI) or Adjuvant On Line (AOL), use grade in their risk calculation.

Tumoral grade is currently assessed by histological methods such as the Elston-Ellis score, which classifies tumors into 3 grade categories of growing potential for proliferation. Grade 2, which represents a substantial percentage of tumors (30-60%), has limited informative value for clinical decision making.

About MapQuant(TM) Genomic Grade

The Genomic Grade test is made available for diagnostic use in Europe through an ISO-17025/CLIA Lab Service. It will soon be available as a product for cancer care centers equipped with a CE-marked, FDA-cleared Affymetrix GeneChip(R) 3000Dx2 (GCS3000Dx2) system. The MapQuant(TM) Dx testing solution for routine micro-array profiling of breast tumors also includes a Path Kit, CE-marked, ensuring easy sampling, RNA-preservation and sample shipping at room Temperature, and a CE-compliant software, ensuring highly reliable quality controls, data processing and genomic test computation. MapQuant(TM) Dx testing solution is developed under the Innovation Support Programme of the French Health Products Safety Agency (AFSSAPS).

About IPSOGEN

Ipsogen, Cancer Profiler, develops and markets molecular diagnostic tests designed to map diseases in order to guide patients and oncologists' decisions along their complex therapeutic path. With more than 70 references already used routinely worldwide for the diagnosis, prognosis and follow-up of thousands of patients with leukemia, Ipsogen is now also targeting breast cancer. As for leukemia, Ipsogen's goal is to provide diagnostic information that was not available until now. Ipsogen is also a partner of choice for biopharmaceutical companies committed to the development of 'companion diagnostic' tests.

Strengthened by its first-rate scientific, clinical and technological partnerships, in addition to its highly skilled multidisciplinary team in France and the USA, Ipsogen is striving to become the leader in molecular profiling of cancers. It continues its efforts to identify develop and commercialise diagnostic tests that will become standard references and will have a significant impact on patients, medical professionals and society.

Ipsogen employed 60 people as of June 30, 2009. Its headquarters are located in Marseille, France. The company also has a subsidiary, Ipsogen Inc., in New Haven, CT, USA.

For more information, visit: http://www.ipsogen.com


'/>"/>
SOURCE Ipsogen SA
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Ipsogen Expands its US Market Presence Through Licensing Agreement With ARUP Laboratories for the Commercialization of JAK2 Molecular Diagnostic Assays
2. Ipsogen Launches a New Test to Determine Tumor HER2 Status and Guide Herceptin(R) Prescription in Breast Cancer
3. Ipsogen Announces Three Studies at the American Society of Clinical Oncology (ASCO) Meeting Extending the Utility of the Genomic Grade Index for Predicting Response to Chemotherapy in Breast Cancer
4. BioCis Pharma Reports Positive Phase IIa Clinical Results in Atopic Dermatitis
5. PARI Pharma Reports Successful Phase Ib Clinical Results for Inhaled Liposomal Cyclosporine A and Gains FDA Orphan Drug Designation for the Prevention and Treatment of Bronchiolitis Obliterans
6. Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer
7. Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401s Activity in the Treatment of Advanced Metastatic Renal Cell Cancer
8. Spherix Reports First Quarter 2009 Earnings
9. Journal of American College of Cardiology Article Reports Fewer Repeat Procedures With Boston Scientifics TAXUS(R) Liberte(R) Stent
10. BioCryst Provides Peramivir Update and Reports First Quarter 2009 Financial Results
11. Alexza Reports 2009 First Quarter Financial Results and Updates Clinical Pipeline Status
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... LONDON , Dec. 7,2016  Based ... drug delivery industry, Frost & Sullivan recognizes ... Frost & Sullivan Award for Enabling Technology ... plug the loopholes in traditional drug delivery ... and liquid microneedle-based drug delivery technologies, Memspatch ...
(Date:12/7/2016)... 7, 2016  Lannett Company, Inc. (NYSE: LCI ) ... Markets 2016 Prescription for Success Healthcare Conference on December 14, 2016 ... New York City . In addition, the ... Guggenheim Securities 4 th Annual Boston Healthcare Conference taking place ... ...
(Date:12/6/2016)... YORK , Dec. 6, 2016 Radioisotopes ... nucleus. Radioisotopes are produced either by using nuclear research ... in the form of alpha, beta or gamma when ... emitted are used in Nuclear medicine, specifically in medical ... provide diagnostic information about a human body,s functioning. Radiotherapy ...
Breaking Medicine Technology:
(Date:12/7/2016)... ... , ... Students attending Envision’s summer 2017 National Youth ... experience in an emergency medical simulation, When Care is Hours Away. This dynamic ... skills that are critical success in a future career and beyond. , The ...
(Date:12/7/2016)... ... December 07, 2016 , ... Silhouette Instalift is a ... smoothing and tightening the skin of the face to create more youthful features. ... with very little downtime, Silhouette Instalift is a novel, minimally invasive facial procedure ...
(Date:12/7/2016)... GA (PRWEB) , ... December 07, 2016 , ... In ... route to respond to an emergency medical call when he lost control of his ... After being extricated from his vehicle, he was transported to Atlanta Medical Center, where ...
(Date:12/7/2016)... ... 07, 2016 , ... Levels of a protein in the blood associated with ... online in the journal Radiology. , Heart disease and brain disease exact a major ... rapidly aging population. Damage to both organs often occurs at a subclinical stage, or ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... services from offices located in South Lyon, Dewitt, Williamston, East Lansing, Ann Arbor, ... coach who needs treatment for a brain tumor. , Jason Bauer and his ...
Breaking Medicine News(10 mins):