"This work demonstrates that high genomic grade, as a robust measure of proliferation in the tumor cells, is associated with benefit from chemotherapy. In the context of other published work it underlines the association between high tumoral proliferation rate and chemosensitivity, endocrine insensitivity and worse prognosis" comments Dr. Symmans, associate Professor of Pathology at the MDACC.
"This study is a straightforward demonstration of the clinical utility of the Genomic Grade index for predicting response to chemotherapy. It also highlights the ongoing commitment of the oncology community to validate new molecular assays that strongly connect with the breast tumor biology and fit within the pathologist's practices" comments Dr. Jean-Marc Le Doussal, Director of Breast Cancer Program at Ipsogen.
Visit Ipsogen booth 23128 at the 44th ASCO annual meeting
In the second study to be presented (abstract 527, (3)), Dr. Pusztai and colleagues showed a pionnering application of multi-testing on genome-wide microarrays by combining the GGi, for the prediction of chemotherapy response, with the 200-gene endocrine-sensitivity index, for the prediction of hormonotherapy response.
"This study further confirms the potential of Ipsogen's pipeline strategy of multiple high-resolution genomic measurements to improve the decision tree of chemotherapeutic options in breast cancer>> says Vincent Fert, CEO of Ipsogen. "We are fully committed to rapidly translate these clinical findings into regulatory-approved and reimbursed test offering to European and American patients," he adds.
One University of Antwerp study
A third study (abstract 11048, (4)), presented by Dr. Van Laere from
Antwerp University, Belgium, validates the pronostic value of the GGi in
inflammatory breast cancer, an aggressive type of breast cancer affecting a
few percent of
Copyright©2008 PR Newswire.
All rights reserved