Navigation Links
Ipilimumab Plus Chemotherapy is Associated with Prolonged Survival and Increased Disease Control Rates in Patients with Advanced Melanoma
Date:6/1/2008

Updated Clinical Phase 2 data presented at American Society of Clinical

Oncology Annual Meeting

PRINCETON, N.J., June 1 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX) today announced updated long-term follow-up and overall survival (OS) results from a Phase 2 clinical study (MDX010-08) of 3 mg/kg of ipilimumab in combination with dacarbazine (DTIC) where 11.4%, or 4 of 35 patients, were still alive at or greater than 4 years of follow-up. This included 1 patient that experienced a complete response (4.7 years), 1 patient that experienced a partial response (4.2 years), 1 patient with stable disease (4.6 years) and 1 patient with RECIST defined progressive disease (4.4 years). The median OS for patients treated with ipilimumab in combination with DTIC was 15 months in this study. These results compare favorably with data in medical literature, in which median OS ranges from 6 to 9 months for patients with treated or previously untreated advanced melanoma treated with standard chemotherapy. These findings were presented at the Annual Meeting of the American Society of Clinical Oncology (ASCO), being held in Chicago, IL May 30-June 3, 2008. (Abstract # 9022)

"The long-term survival data suggests that ipilimumab in combination with DTIC may have long-lasting effects," said Geoffrey M. Nichol, MBChB, Senior Vice President of Product Development at Medarex. "With a median survival of approximately 15 months in the patients treated with 3 mg/kg of ipilimumab in combination with DTIC in this Phase 2 study, we look forward with interest to the outcome of the ongoing Phase 3 study being performed by our collaborator Bristol-Myers Squibb Company, comparing 10 mg/kg of ipilimumab in combination with DTI
'/>"/>

SOURCE Medarex, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Medarex Reports Interim Data from Ongoing Ipilimumab Combination Phase 1 Studies in Prostate Cancer at American Association for Cancer Research Meeting
2. Medarex Announces Ipilimumab Program Continues to Move Forward
3. New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens
4. Genasense(R) Chemotherapy Program Yields High Response Rate in Patients with Stage 4 Melanoma
5. Node-Negative Early Stage Breast Cancer Patients Benefit from Taxotere(R)-Based Chemotherapy
6. Elesclomol Study Shows Significant Improvement in Progression-Free Survival for Chemotherapy-Naive Patients With Metastatic Melanoma
7. Ipsogen Announces Three Studies at the American Society of Clinical Oncology (ASCO) Meeting Extending the Utility of the Genomic Grade Index for Predicting Response to Chemotherapy in Breast Cancer
8. Studies Point to Benefits of Personalized Chemotherapy Dose Management in Colorectal Cancer
9. Karmanos Researchers Find Non-Toxic Agents Added to Conventional Chemotherapy Decrease Survival of Colon Cancer Cells
10. Totality of Available Data Reaffirms PROCRIT(R) (Epoetin alfa) Is Safe and Effective When Used Appropriately as Labeled to Treat Chemotherapy-Induced Anemia
11. Observational Data Show Transfusion Patterns in Chemotherapy-Induced Anemia Patients Receiving Erythropoiesis-Stimulating Agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... , May 6, 2015 The Parenteral Drug ... has finalized agreement with Richard M. Johnson ... "We are very pleased to have Richard ... Hal Baseman , the Chair of the Board ... performance and growth.  Richard has led a strong staff ...
(Date:5/6/2015)... PARIS , May 6, 2015 ... the development and manufacture of filtration products, mainly for ... ZenPure designs custom filters manufactured in a state-of-the-art plant ... are marketed and sold across the globe and will ... Plastics business. This acquisition is fully in ...
(Date:5/6/2015)... DUBLIN , May 06, 2015 Research ... announced the addition of the "Global Suture ... The Global Suture Industry Report 2015 ... current state of the suture industry. ... industry including definitions, classifications, applications and industry chain ...
Breaking Medicine Technology:PDA Extends Richard M. Johnson as President/CEO for Six Additional Years 2Saint-Gobain Acquires ZenPure, a Specialist in Filtration Products 2Global Suture Industry Report 2015 - Forecast Trends to 2021 2Global Suture Industry Report 2015 - Forecast Trends to 2021 3
... effort to meet industry demands for expanded Cephalosporin ... administration, B. Braun Medical Inc. (B. Braun) announced ... USP and Dextrose Injection USP in B. ... will be available for purchase beginning today. ...
... NXTM ), a leading manufacturer of innovative dialysis ... the third quarter ended September 30, 2010 on Thursday, November ... NxStage will also host a conference call at 9:00 ... its third quarter financial results. To listen to the conference ...
Cached Medicine Technology:FDA-Approved Cefepime Now Available for Use in B. Braun's DUPLEX® System 2NxStage to Report Third Quarter Fiscal 2010 Financial Results 2
(Date:5/6/2015)... (PRWEB) May 06, 2015 Corporate ... behalf of MEBC, an Alliance Award for excellence ... during FOCUS 2015, JDA’s annual user conference which ... retail and wholesale distribution sectors. This award recognizes ... are receiving services that advance their supply chain ...
(Date:5/6/2015)... Baptist Medical Center Jacksonville and ... north Florida and southeast Georgia region offering MAKOplasty® ... in total hip replacement surgery performed using the ... that enables the accurate alignment and positioning of ... MAKOplasty® partial knee resurfacing using the RIO system ...
(Date:5/6/2015)... 06, 2015 “ SideChef ” was featured on ... at the latest and coolest applications on the market for iOS, ... expert, conducted the app review and shared with viewers how this ... day when to be a good navigator people had to know ... now everyone is a master navigator. Well what if people could ...
(Date:5/6/2015)... 06, 2015 Anitha Nallari, MD ... Oncology Consultants, Inc. in Columbus, OH. Dr. Nallari will ... special focus in breast cancer, lung cancer, GI and gallbladder ... well as benign hematology. , Dr. Anitha Nallari ... by the American Board of Internal Medicine. She completed her ...
(Date:5/6/2015)... Follow us on LinkedIn ... by the rising consumer awareness over the importance of ... Hand washing is becoming a part of personal hygiene ... infections. Periodic outbreak of Avian flu, Swine flu, and ... disease (EVD) epidemic in West Africa are mega ...
Breaking Medicine News(10 mins):Health News:MEBC Receives Award for Consulting Excellence in Retail 2Health News:Baptist Health and Jacksonville Orthopaedic Institute Offering MAKOplasty® Total Hip Replacement 2Health News:Baptist Health and Jacksonville Orthopaedic Institute Offering MAKOplasty® Total Hip Replacement 3Health News:Baptist Health and Jacksonville Orthopaedic Institute Offering MAKOplasty® Total Hip Replacement 4Health News:An Application to Guide Users through Recipes Was Featured on NewsWatch Television 2Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 2Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 3Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 2Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 3Health News:Growing Apprehension Amid Disease Outbreaks Drives Global Sales of Hand Sanitizers, According to a New Report by Global Industry Analysts, Inc. 4
... to reduce the problems caused by pollen , SATURDAY, ... many allergy sufferers, will soon be in bloom. , ... nose, sore throat, congestion and problems sleeping for the ... the American Academy of Allergy, Asthma & Immunology (AAAAI). ...
... ... spreading, one of the best protections may actually be right under our nose. FDNSC, ... adding another much needed layer of prevention against the flu viruses. , ... Tampa, FL (PRWEB) August 29, 2009 -- As ...
... infected with type D were affected, study found , ... HIV a person has may determine their odds for ... Cognitive difficulties, even dementia, are a common hallmark of ... led by Dr. Ned Sacktor noted that people in ...
... New White Paper Reveals the Proposed Rationing of Quality Hospital ... Today, the Senior Center for Health and Security (SCHS) announced ... the critical nature of high-quality physician hospitals for seniors, their promise ... completely out of existence. , , "According to ...
... PITTSBURGH, Aug. 28 Children,s Hospital of Pittsburgh ... research organization, as the leader in its use of healthcare ... , KLAS interviewed leaders at virtually every ... actively using commercially available software to order and chart under ...
... , CINCINNATI, Aug. 28 Dr. Will ... that the American public is NOT getting adequate information on how ... Flu (Swine Flu)! Sawyer,s advice includes, crucially, "Do NOT Touch ... contamination (inoculation) of mucus membranes, which are the portal of entry ...
Cached Medicine News:Health News:Get Ready for Ragweed 2Health News:First Defense Nasal Screen Comp. Releases New Protection Product Just in Time for Pandemic Flu Season 2Health News:First Defense Nasal Screen Comp. Releases New Protection Product Just in Time for Pandemic Flu Season 3Health News:First Defense Nasal Screen Comp. Releases New Protection Product Just in Time for Pandemic Flu Season 4Health News:America Needs More Physician Hospitals 2Health News:Children's Hospital of Pittsburgh of UPMC Recognized for Deepest Use of Electronic Health Records for a Pediatric Hospital in Nation 2Health News:Children's Hospital of Pittsburgh of UPMC Recognized for Deepest Use of Electronic Health Records for a Pediatric Hospital in Nation 3Health News:Solution to PREVENT Novel H1N1 (Swine Flu) From Closing Down Schools! 2
... Neonatal and Pediatric TRACH ... for intubated patients. Rounded ... provide smooth surface interface. ... locking thumb port. Multiple ...
... spiral reinforced. X-ray opaque. Super safety low ... use. Adjustable Flange: The flange can be ... the thickness of the cervical soft tissue. ... the flange is tightly connected to the ...
... patients with obstructive sleep apnea necessitating tracheotomy, ... support. Also indicated where airway access for ... ,Another excellent choice for a sleep ... tube series. Available with a low profile ...
... patient safety, the laryngectomy tube ... 15 mm ISO termination that ... ventilator, with or without the ... ,Portex® laryngectomy tubes are ...
Medicine Products: