Navigation Links
Investigational Oral Multiple Sclerosis Therapy Teriflunomide (Aubagio™(*)) Significantly Reduced Relapse Rate, Disability Progression and Disease Activity
Date:10/5/2011

nomide compared to placebo. No serious or opportunistic infections and no deaths occurred in trial participants treated with teriflunomide.  The proportion of participants who discontinued the study medication because of disease progression was significantly smaller in the group receiving the 14mg of teriflunomide than in the placebo group (p=0.02). Malignancies were reported in three participants in the placebo group and one in the teriflunomide 14mg group.

Teriflunomide adverse events were usually of mild to moderate intensity, managed with existing therapies and rarely led to treatment discontinuation. The most common were diarrhea, nausea, liver enzyme increases (that were mainly mild and asymptomatic with no dose effect) and mild hair thinning/decreased hair density. In general, diarrhea, nausea and alopecia, were mild to moderate, transient, and infrequently led to treatment discontinuation.

About Teriflunomide
Teriflunomide is an immunomodulatory, disease-modifying oral drug with anti-inflammatory properties, and is under investigation for the treatment of MS. Teriflunomide blocks the proliferation and functioning of activated T and B  lymphocytes - which are thought to be especially damaging in MS - by selectively and reversibly inhibiting a critical mitochondrial enzyme. Slowly dividing or resting lymphocytes are unaffected by teriflunomide, leaving the immune system's response to infection uncompromised. With nine years of continuous use in a Phase II extension, teriflunomide has the longest clinical experience of any investigational oral MS therapy. In addition to the TEMSO trial, two other Phase III trials, TOWER and TENERE, are ongoing in people with RMS. A Phase III study, TOPIC, is also underway in early MS or CIS (clinically isolated syndrome). Teriflunomide is also being evaluated as an adjunct therapy to interferon-beta in the Phase III TERACLES trial.

(*) Aubagio™ is the registered name submitted to
'/>"/>

SOURCE Sanofi; Genzyme
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Puma Biotechnology Announces Licensing Agreement with Pfizer for the Development and Commercialization of Neratinib, an Investigational Pan-HER Inhibitor; Closes $55 Million Private Placement and Completes Merger
2. Positive Phase III Data on Bayers Investigational Drug Radium-223 Chloride Show Significant Increase in Overall Survival
3. New Study Published in New England Journal of Medicine Shows Investigational BIBF 1120 Demonstrated Positive Trend in Reducing Lung Function Loss in Idiopathic Pulmonary Fibrosis
4. Bayer to Present New Data Evaluating Investigational Oncology Compounds at 2011 ECCO-ESMO Congress
5. Boehringer Ingelheim Broadens Its Breast Cancer Clinical Trial Program for the Investigational Compound Afatinib
6. FDA Grants Fast Track Designation to Bayers Investigational Compound Radium-223 Chloride for the Treatment of Castration-Resistant Prostate Cancer That Has Spread to the Bone
7. CoLucid Pharmaceuticals Receives Clearance for Investigational New Drug (IND) Application for Lasmiditan for the Treatment of Acute Migraine
8. Marshall Edwards Announces FDA Approval of Investigational New Drug Application for Lead Candidate ME-143
9. Takeda Resubmits New Drug Applications in the U.S. for Investigational Type 2 Diabetes Therapies Alogliptin and the Fixed-Dose Combination Alogliptin/Pioglitazone
10. Positive Results for Investigational Compound Lyxumia® (Lixisenatide) Presented at American Diabetes Associations 71st Annual Scientific Sessions
11. Morphotek, Inc. Announces That Two Investigational Drugs Have Received Orphan Drug Designations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... , July 28, 2014 STAAR Surgical ... manufacturer and marketer of implantable lenses and delivery systems ... second quarter results and conference call with investors to ... 30, 2014.  The Company rescheduled the release date and ... funeral services for Hideo Watanabe , President of ...
(Date:7/28/2014)... FRANCISCO, Calif. , July 28, 2014 ... provided an update on the status of the KB001-A ... with Sanofi Pasteur.  KB001-A Collaboration ... an agreement with Sanofi Pasteur to regain all rights ... and licensing agreement entered into in 2010 has been ...
(Date:7/28/2014)... 2014  Serco Inc., a provider of professional, ... been awarded a re-compete contract to support the ... Deployable Medical Systems.  Serco will provide deployable medical ... world-class healthcare to meet warfighter and humanitarian requirements ... The five year contract has a one-year base ...
Breaking Medicine Technology:STAAR Surgical Moves Second Quarter Earnings Release and Conference Call One Day to July 31 2KaloBios Provides Update on KB001-A Partnership and Clinical Status 2KaloBios Provides Update on KB001-A Partnership and Clinical Status 3KaloBios Provides Update on KB001-A Partnership and Clinical Status 4KaloBios Provides Update on KB001-A Partnership and Clinical Status 5KaloBios Provides Update on KB001-A Partnership and Clinical Status 6Serco Awarded $22.7 Million Contract to Support Deployable Medical Systems 2
... 14 SARcode Corporation, a privately-held biotechnology company focused ... (LFA-1) antagonists, today announced that Quinton Oswald has joined ... Mr. Oswald brings significant commercial experience and management expertise ... he served as the Vice President & Business Unit ...
... M.D., a 20-year veteran of the consulting and pharmaceutical ... marketing consulting firm ZS Associates as associate principal. ... "I am excited to work with the ZS ... respond to business challenges posed by their internal and ...
Cached Medicine Technology:Quinton Oswald Named Chief Executive Officer of SARcode Corporation 2Quinton Oswald Named Chief Executive Officer of SARcode Corporation 3ZS Associates Appoints Pharmaceutical Industry Veteran to Serve the Firm's Growing Client Base in Germany 2
(Date:7/28/2014)... 2014 The “Tissue Diagnostics ... Digital pathology & Workflow, Special Staining), Disease ... Non Small Cell Lung Cancer and Others), ... companies, Research Laboratories, Contract Research Organizations and ... BRIC, Japan & RoW) - Trends & ...
(Date:7/28/2014)... “China Surgical Generators Market Outlook ... China Surgical Generators market. The report provides value, ... and average prices (in US dollars) within market ... and Argon Plasma Coagulation Generators. , The report ... for each of these market categories, and global ...
(Date:7/28/2014)... 28, 2014 Camp Soaring Eagle ... camp property in Cornville, AZ. The nonprofit organization, ... with the opportunity to attend medically supervised camps ... The organization offers a variety of programs to ... and life threatening illnesses including: Illness Specific Camping ...
(Date:7/28/2014)... Heights, MI (PRWEB) July 28, 2014 ... UHY, introduces the latest edition of UHY International Business ... provided by our members, on the most current business ... around the world. Issue 29 covers the following topics:, ... growth: Which industry sectors will thrive over the next ...
(Date:7/28/2014)... An estimated 68,000 women and men in the ... cancers – an aggressive form of the disease that ... of the body, such as the lungs, liver, bones, ... of Medicine have developed a compound directed at ... blocking tumor cells from “re-seeding.” Their discovery has been ...
Breaking Medicine News(10 mins):Health News:Advanced Cancer Diagnostics Market Worth $3,924.01 Million by 2018 - New Report by MarketsandMarkets 2Health News:Advanced Cancer Diagnostics Market Worth $3,924.01 Million by 2018 - New Report by MarketsandMarkets 3Health News:Advanced Cancer Diagnostics Market Worth $3,924.01 Million by 2018 - New Report by MarketsandMarkets 4Health News:Advanced Cancer Diagnostics Market Worth $3,924.01 Million by 2018 - New Report by MarketsandMarkets 5Health News:Key Market Data on China Surgical Generators Market to 2020 Report Available at MarketOptimizer.org 2Health News:Key Market Data on China Surgical Generators Market to 2020 Report Available at MarketOptimizer.org 3Health News:Key Market Data on China Surgical Generators Market to 2020 Report Available at MarketOptimizer.org 4Health News:Camp Soaring Eagle Announces New Camp Site 2Health News:Camp Soaring Eagle Announces New Camp Site 3Health News:Uhy International Business Issue 29 Now Available 2Health News:Uhy International Business Issue 29 Now Available 3Health News:Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells 2Health News:Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells 3
... the proposal of the Ministry of Health to hike the ... ,"A committee has been set up to review fees charged ... medical sector. This includes the licensing and renewal of licenses ... the medical or health establishments as well," said Dr Ibrahim ...
... Ahmedabad. A man suspected with avian influenza infection ... ,Qadar Abubhai Marghiwala, a 30-year-old resident of ... fever for a week., ,Gujarat's Health Minister ... as primary investigations revealed negative results., ,According ...
... taboo with a study on the mounting violence against women. ... supported with funds from the United Nations Development Fund for ... beaten -- usually by her husband or father. A campaign ... ,In Syria violence against women is usually from ...
... to six times as much sunlight as those with fair ... a new study// . ,Researchers at the Australian ... in the summer sunshine to produce enough Vitamin D whereas ... ,Acceptable levels of sunbathing also depends on geography ...
... people as young as 16 whereas the phenomenon once occurred only ... can escape stress in modern day life. Stress increases glucocorticoid levels. ... hair," Mumbai-based Sonal Shah said. ,"Initially, we used to ... to as low as 16 and 18," Shah told IANS on ...
... A new species that provides the missing evolutionary link between ... onto the land about 375 million years ago//, has been ... a skull, a neck, ribs and parts of the limbs ... ,These fossils, found on Ellesmere Island in Arctic ...
Cached Medicine News:Health News:Stress Can Cause Hair loss at 16 2Health News:Species Linking Fish And Land Animals Found 2Health News:Species Linking Fish And Land Animals Found 3
... Precision Hand Instruments were developed in surgeon's ... while still having an instrument with the ... the fear of the bending or breaking. ... manufactured to conform to the surgeon's hand. ...
... Instruments were developed in surgeon's desire to ... having an instrument with the strength to ... of the bending or breaking. Arthrotek Hand ... conform to the surgeon's hand. This new ...
... Hand Instruments were developed in surgeon's desire ... still having an instrument with the strength ... fear of the bending or breaking. Arthrotek ... to conform to the surgeon's hand. This ...
... Hand Instruments were developed in surgeon's desire ... still having an instrument with the strength ... fear of the bending or breaking. Arthrotek ... to conform to the surgeon's hand. This ...
Medicine Products: