Inverseon's Founder and SAB Member Publish... ( SAN FRANCISCO Feb. 19 /- Inverseon In...)

Inverseon's Founder and SAB Member Published in PNAS

Date:2/19/2009

SAN FRANCISCO, Feb. 19 /PRNewswire/ -- Inverseon, Inc. (http://www.inverseon.com) announces the publication in the February 17, 2009 issue of the Proceedings of the National Academy of Sciences (PNAS) entitled, "Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model." The article was edited by Robert Lefkowitz, The James B. Duke Professor of Medicine at Duke University, and there is an accompanying supportive commentary on this essential asthma signaling pathway by Raymond Penn of the University of Maryland School of Medicine.

"This work using knockout mice confirms prior results from Bond and collaborators using inverse agonists, a subset of beta blockers, in mice and patients (Callaerts-Vegh PNAS 2004; Nguyen AJRCMB 2008; Hanania 2008) that a reduction in Beta2-adrenoceptor signaling attenuates the asthma phenotype. The current work extends the prior observations by ruling out the possibility that the effects of inverse agonists are exerted via biased agonism. Together, these are a remarkable set of observations that point the way towards a possible therapeutic strategy based upon the use of drugs that had previously been considered contraindicated in asthma. The precise mechanism by which Beta2-adrenoceptor signaling exacerbates the asthma phenotype is not yet known, but is an active area of study. Fully understanding this phenomenon and exploiting it therapeutically will be of tremendous interest to the asthma community," commented Burton F. Dickey, MD, Professor & Chair, Dept. of Pulmonary Medicine, M.D. Anderson Cancer Center and Inverseon Scientific Advisory Board member.

About Inverseon, Inc.

Inverseon's product development programs target significant unmet medical needs and major market opportunities in chronic pulmonary diseases such as asthma, COPD and pulmonary hypertensi
'/>"/>

1

GOOD

Page: 1 2
Related medicine technology :

1. Open Letter to President-Elect Barack Obama From Don Margolis, Chairman and Founder of The Repair Stem Cell Institute
2. International Medical Corps Matched with Top 25 American Express Members Project, Saving the Lives of Malnourished Children
3. Nobel Prize Awarded to Foundation for Biomedical Research Board Member
4. Pivotal Data Published For First Biomarker Combination Test to Determine Risk of Ovarian Cancer in Women Who Present With Pelvic Mass
5. Synvista Therapeutics Announces Published Data Demonstrating Elevation of Carboxymethyl-Lysine (CML) Is Associated with Decline in Renal Function and Arterial Stiffness in Older Adults
6. Clinical Trial Results on the Sleep-Promoting Effects of Vanda Pharmaceuticals Circadian Regulator Tasimelteon (VEC-162) Published in The Lancet
7. Rigels R788 Phase 2a Results Published in Arthritis and Rheumatism
8. Comprehensive Safety Tests Published on Ruyan(R) Smoking Alternatives
9. Technique for Rapidly Reprogramming Adult Cells Into Stem Cells Published in PLoS Biology
10. Diamyd(R) Study Published in Prestigious New England Journal of Medicine
11. Study Published in Journal of Clinical Psychiatry Showed Once-Daily VYVANSE(R) (lisdexamfetamine dimesylate) Significantly Improved ADHD Symptoms in One of the Largest Controlled Stimulant Trials in Adults with ADHD

Post Your Comments:

Inverseon's Founder and SAB Member Publish...( SAN FRANCISCO Feb. 19 /- Inverseon In...),Health