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Intravenous (IV) Administration of Cempra Pharmaceutical's Solithromycin (CEM-101) Demonstrates Excellent Systemic Tolerability in a Phase 1 Clinical Trial
Date:5/7/2011

European pathogens commonly isolated in CABP and ABSSSI.  

Farrell et al. (Abst. P1452) investigated the activity of solithromycin against almost 1,200 H. influenzae strains acquired from patients with CABP in 24 countries as part of the SENTRY antimicrobial surveillance program from 2009.  Solithromycin had greater potency than telithromycin, with MIC50 and MIC90 values of one and two micrograms/mL, respectively. Solithromycin resistance, found in nine of the 1,198 isolates (less than one percent), was rare, and when observed was attributed to ribosomal gene mutations.

TAKSTA (CEM-102, sodium fusidate)

TAKSTA is sodium fusidate delivered with a proprietary front-loading dosing regimen to enhance spectrum of activity, optimize efficacy and reduce resistance development.  Sodium fusidate has a long and established record of safety and efficacy outside the U.S.  Jones et al. (Abst. P944) evaluated the activity of fusidic acid against over 16,000 contemporary gram positive pathogens associated with ABSSSI isolated in the U.S. from 2008 to 2010.  Twelve thousand of these strains were S. aureus, of which 52 percent were MRSA; 2,000 strains were coagulase-negative staphylococci (CoNS); and 2,000 were beta-haemolytic streptococci (group A and B).  Fusidic acid was highly active against all ABSSSI strains including S. aureus (99.73 percent at less than 1 micrograms/mL), with both methicillin-sensitive and MRSA strains having similar sensitivity rates.  Methicillin-resistant CoNS was slightly less sensitive (90.76 percent) than methicillin-sensitive CoNS (97.28 pe
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