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Intradigm Study Shows Ability of siRNAs Systemically Delivered With TargeTran(TM) System to Suppress Tumor-Induced Angiogenesis in Mice
Date:10/24/2007

Positive Findings Support Preclinical Development of Intradigm's ICS-283

PALO ALTO, Calif., Oct. 24 /PRNewswire/ -- Intradigm Corporation, a leading developer of targeted, systemic RNA interference (RNAi) therapeutics, today announced study results that demonstrated the company's TargeTran(TM) delivery system is capable of delivering vascular endothelial growth factor (VEGF) targeted small interfering RNAs (siRNAs) that suppress tumor-induced angiogenesis by silencing target gene expression in mice. The study findings support the preclinical development of ICS-283 a nanoparticle-based compound comprised of siRNAs that target both VEGF and its main receptor. Complete study findings were presented by Intradigm scientists today at the 2007 AACR- NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.

This preclinical study was designed to examine the anti-angiogenic efficacy, in multiple cancer types, of VEGF-targeted siRNAs administered systemically with Intradigm's proprietary RNAi Nanoplex(TM) delivery technology using the TargeTran(TM) delivery system. At the study's outset, tumor cells (both human colorectal and renal cell carcinoma) were implanted into a group of mice. At both two and five days post tumor cell introduction, a portion of the mice were given intravenous (IV) administration of several siRNAs targeting VEGF ligand, VEGFR1, VEGFR2, or various combinations of the three. The remaining mice received either a negative control siRNA treatment or a positive control treatment using VEGF antibody Bevacizumab. At eight days, tumor-induced angiogenesis as well as target gene knockdown were analyzed. The results showed highly significant anti-angiogenic effect that is RNAi-mediated in all active siRNA treatment groups targeting different VEGF-pathways genes.

"These study results are very encouraging as they demonstrate the ability of our RNAi Nanoplex(TM) technology to systemically deliver siRNA therapeutics direc
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SOURCE Intradigm Corporation
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