Navigation Links
Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia
Date:12/20/2007

NEW YORK, Dec. 20 /PRNewswire/ -- Intra-Cellular Therapies, Inc. (ITI), today announced it has initiated a sleep maintenance insomnia (SMI) Phase 2 clinical study using its drug candidate ITI-722. ITI-722 acts predominantly as a selective 5-HT2A receptor antagonist and represents an important new approach to the treatment of SMI. Because of its novel separation of 5-HT2A and dopamine receptor modulatory activities, ITI believes, ITI-722 can be used not only to treat SMI but it may be highly appropriate for the treatment of sleep disorders that accompany neurodegenerative disorders, including Parkinson's disease and other psychiatric disorders.

"The progression of ITI-722 into Phase 2 for SMI represents the advancement of this important new class of therapeutics," stated Sharon Mates, Ph.D., Chairman and Chief Executive Officer of Intra-Cellular Therapies. "This drug candidate has therapeutic potential to treat SMI in the general population, and in other patient populations who have been underserved, particularly peri- and post-menopausal women, and in other disorders where insomnia is a problem, including osteoarthritis, depression, Parkinson's disease and other neurologic and psychiatric disorders."

The Phase 2 program is a multi-center, randomized, double-blind placebo- controlled study in patients with SMI. The primary endpoint is an assessment of objective slow wave sleep using polysomnography (PSG). Secondary endpoints include other objective and subjective measures of SMI and sleep efficiency. Additionally, the study will make an assessment regarding next-day cognitive performance.

ITI-722 is a low-dose formulation of ITI-007, ITI's first-in-class 5-HT2A antagonist/ dopamine receptor protein phosphorylation modulator (DPPM), presently in clinical trials for the treatment of schizophrenia.

About Sleep Maintenance Disorders

From nightmares to insomnia to sleep apnea, sleep disorders disrupt the sleep of millions of peopl
'/>"/>

SOURCE Intra-Cellular Therapies, Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Intra-Cellular Therapies Presents Preclinical Data From Schizophrenia and Sleep Maintenance Programs
2. LigoCyte Pharmaceuticals Announces Collaboration With Biogen Idec to Develop Anti-CD103 Therapies
3. ActiveSight and CHDI Leverage Fragment-Based Lead Discovery for Huntington Disease Therapies
4. New Data Show Doripenem as Effective as Commonly Used Therapies in Treating Hospital-Acquired Pneumonias
5. NIST Awards $2 Million to Velcura Therapeutics, Inc. for Innovative Technology R&D - Dual-Action Therapies for Bone Disease
6. Studies Attribute Recent Increase in Multiple Myeloma Survival to Novel Therapies
7. Vital Therapies Announces Presentation of ELAD(R) Artificial Liver Data at American Association for the Study of Liver Diseases 2007 Annual Meeting
8. New Data to Support VELCADE(R) (Bortezomib) For Injection Based Therapies as Setting New Standards in The Care of Newly Diagnosed Patients With Multiple Myeloma
9. Carrington Subsidiary DelSite Initiates Critical Toxicology Studies of Its Nasal Powder Bird Flu Vaccine
10. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
11. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/20/2009)...tCall/ -- Biotel Inc. (OTC Bulletin Board: BTEL) a...mber 30, 2009 with net earnings of $128,000, or $0... This compares to net earnings of $328,000, or $0....r the first quarter of last year. ,, Commenting...d CEO Steve Springrose said: "Biotel enjoyed stron...
(Date:11/20/2009)...re-FirstCall/ -- Soligenix, Inc. (OTC Bulletin Boa...wn as DOR BioPharma, Inc., a late-stage biotechnol...consortium to develop thermostable technology to a.... Soligenix received a $9.4 million grant from the...ases (NIAID), a division of the National Institute...
(Date:11/19/2009)...swire-Asia/ -- ScinoPharm, a leading global,suppli...nounced that its,Tainan facility has received the ...ge(R) Consultants, Inc. The Certification confirms...fe handling of potent active,pharmaceutical ingred... and,production areas used for the manufacturing a...
Breaking Medicine Technology:Biotel Announced Profitable First Quarter Ended September 30, 2009 2Soligenix Forms Consortium to Develop Thermostable Technology to Advance RiVax(TM) and Other Rapidly Acting Vaccines 2Soligenix Forms Consortium to Develop Thermostable Technology to Advance RiVax(TM) and Other Rapidly Acting Vaccines 3Soligenix Forms Consortium to Develop Thermostable Technology to Advance RiVax(TM) and Other Rapidly Acting Vaccines 4Soligenix Forms Consortium to Develop Thermostable Technology to Advance RiVax(TM) and Other Rapidly Acting Vaccines 5Soligenix Forms Consortium to Develop Thermostable Technology to Advance RiVax(TM) and Other Rapidly Acting Vaccines 6ScinoPharm Announces SafeBridge Potent Compound Safety Certification 2Transgenomic Inc Reports Second Quarter 2009 Results 13536 1Transgenomic Inc Reports Second Quarter 2009 Results 13536 2Transgenomic Inc Reports Second Quarter 2009 Results 13536 3Transgenomic Inc Reports Second Quarter 2009 Results 13536 4Transgenomic Inc Reports Second Quarter 2009 Results 13536 5Transgenomic Inc Reports Second Quarter 2009 Results 13536 6Transgenomic Inc Reports Second Quarter 2009 Results 13536 7Transgenomic Inc Reports Second Quarter 2009 Results 13536 8St Anthonys Hospital Offers First Ambient MRI In Florida 4849 1St Anthonys Hospital Offers First Ambient MRI In Florida 4849 2St Anthonys Hospital Offers First Ambient MRI In Florida 4849 3Scientists demonstrate importance of niche differences in biodiversity 9554 1Scientists demonstrate importance of niche differences in biodiversity 9554 2
...ralia, March 27, 2007--CSL Limited,today announced...the American Medical Association that suggest infu...se HDL (“good”,cholesterol) levels, ma...ries of patients with a recent episode of acute,co...ct of Reconstituted HDL on,Atherosclerosis –...
...tudy Demonstrates 50% Survival in Valortim-Treated...rch 29, 2007,/PRNewswire-FirstCall/ -- Medarex, In...armAthene, Inc., a privately held,biotechnology co...ountermeasures, today announced that Valortim(TM),...te being developed for the,prevention and treatmen...
Other Medicine Technology:CSL Therapy That Mimics “Good” Cholesterol May Reduce,Plaque Volume in Coronary Arteries 2CSL Therapy That Mimics “Good” Cholesterol May Reduce,Plaque Volume in Coronary Arteries 3Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic,Effect in New Primate Model of Established Anthrax Infection 2Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic,Effect in New Primate Model of Established Anthrax Infection 3Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic,Effect in New Primate Model of Established Anthrax Infection 4Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic,Effect in New Primate Model of Established Anthrax Infection 5Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic,Effect in New Primate Model of Established Anthrax Infection 6Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic,Effect in New Primate Model of Established Anthrax Infection 7Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic,Effect in New Primate Model of Established Anthrax Infection 8
(Date:11/20/2009)..., (Seattle, Washington) November 20, 2009Emergenc...ates assess an estimated 350,000 cardiac arrests e... sudden cardiac arrest survive. Better quality ca...ospital EMS providers may be associated with bette...sortium (ROC) is the largest clinical research net...
(Date:11/20/2009)... 1 in 4 thinks it,s as short as 34 weeks, potentia..., , FRIDAY, Nov. 20 (HealthDay News) -- R...ries continues to climb in the United States. Now...are confused about what constitutes a full-term bi...new mothers surveyed in the study considered a bab...
(Date:11/20/2009)... Canadian study finds more severe cases than with ...hDay News) -- Canadian researchers are reporting t...p severe cases of H1N1 flu than seasonal flu. ,... factor for admission with pandemic H1N1 influenza...r samples," wrote Dr. Upton Allen and fellow resea...
(Date:11/20/2009)..., Longtime OB/GYN warns a...sed by the U.S. Preventative Services Task Force. ...ome at the price of human lives. When is it wrong ...The new U.S. Preventative Services Task Force reco... Annals of Internal Medicine, has set off a firest...
(Date:11/20/2009)..., , SPRINGFIELD, Mo., Nov. 20 /PRNewswire/...South Central Missouri regions will now have the o...reement reached Tuesday between Missouri Consolida...s. ,, The Southwest and South Central Missouri ...ton, Cedar, Christian, Dade, Dallas, Douglas, Gree...
Breaking Medicine News(10 mins):Health News:Effect of real-time CPR feedback reported at resuscitation science symposium 2Health News:Effect of real-time CPR feedback reported at resuscitation science symposium 3Health News:Many Women Miscalculate Time to Full-Term Birth 2Health News:Many Women Miscalculate Time to Full-Term Birth 3Health News:Many Women Miscalculate Time to Full-Term Birth 4Health News:New Breast Cancer Recommendation May Cost Lives While Saving Money 2Health News:New Breast Cancer Recommendation May Cost Lives While Saving Money 3Health News:Missouri Consolidated Health Care Plan Provides Mercy Health Plans Option 2
... medicines with the right food could improve the e...apidly rising costs of treating patients, experts ...ists Mark Ratain, MD, and Ezra Cohen, MD, have rel...d absorption of the drug. Previo...
...n example for others to follow, the Varanavasi Vil...imposed a ban on tobacco consumption among village...of tobacco consumption, the village panchayat unan...cco products like cigarette and gutka. Hence, the ...
...lly should stop complaining about their problems w...se who do so, are at a greater risk of developing ...ciate professor of psychological sciences in the C... seventh and ninth grade students - boys and girls...
...n minister in charge of womens affairs has announc...up hospices for HIV positive women . Minis...ry said, "We plan to start hospices in villages fo...iant." The hospices would be in village...
...s in the US have claimed that scorpion venom may h... Scorpions occur naturally in parts of Afri... of scorpions are harmless to human beings althoug... in scorpion venom can distinguish cancer from hea...
... origin scientist at the Rensselaer Polytechnic In...artificial muscles using carbon nanofibres . ...stimulus, thereby creating a smoother, more human-...mplantation, say scientists. Today's most pro...
Other Medicine News:Health News:Right Foods Could Improve Drug Effectiveness, Lower Drug Costs 2Health News:Village Panchayat in Tamil Nadu Bans Tobacco Consumption 2Health News:Complaining Girls Faces Higher Depression, Anxiety Risk 2Health News:India Plans Hospices for HIV Positive Women 2
...em is the worlds first tri-modal cataract removal ...lows surgeons to,choose from three different met...tem features revolutionary Fluidics and unique tri...ase Liquefaction Device, Ultrasound and NeoSoniX h...
...omputerized medical record system whose goal is to...ractice as well as improve the degree and ease of ...commonly presenting problems based on the chief co...o cover rare diagnostic entities. It covers the ch...
Veatch 2V
ReSeeVit 5Z
Medicine Products: