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Intra-Cellular Therapies Announces the Successful Completion of a Phase Ib/II Study of ITI-007 in Patients with Schizophrenia
Date:7/29/2010

f bladder control. Few people with schizophrenia regain normal psychosocial function. The medical need in this disease area is enormous.

ABOUT ITI-007

ITI-007 is a unique, orally available, investigational drug being developed for the treatment of schizophrenia and other neuropsychiatric diseases such as bipolar disorder, major depressive disorder, sleep maintenance insomnia, and for insomnia associated with psychiatric and neurological disorders, such as depression, post-traumatic stress disorder, traumatic brain injury, Parkinson's disease, Alzheimer's disease and mild cognitive impairment.

ITI-007 has a novel combination of pharmacological properties revealed by CNSProfile™ technology that will define the next generation of antipsychotic drugs. ITI-007 combines potent 5-HT2A receptor antagonism with cell-type-specific modulation of phosphoprotein pathways downstream of dopamine receptors. As a dopamine receptor phosphoprotein modulator (DPPM), ITI-007 has dual properties, acting as a post-synaptic antagonist and as a pre-synaptic partial agonist at D2 receptors with mesolimbic/mesocortical selectivity. ITI-007 also stimulates phosphorylation of glutamatergic NMDA NR2B receptors, in a mesolimbic specific manner downstream of D1 receptor intracellular signaling.  This regional selectivity in brain areas thought to mediate the efficacy of antipsychotic drugs together with a broad serotonergic, glutamatergic, and dopaminergic approach is expected to result in superior antipsychotic efficacy for positive, negative and cognitive symptoms associated with schizophrenia.  Also unusual among antipsychotic drugs is ITI-007's serotonin reuptake inhibition at clinically relevant doses providing antidepressant efficacy as well as antipsychotic efficacy. The unique combination of ITI-007's high-potency blockade of 5-HT2A receptors and DPPM activity should allo
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SOURCE Intra-Cellular Therapies, Inc.
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1. Intra-Cellular Therapies Announces the Results of a Phase I PET Study for ITI-007 for the Treatment of Schizophrenia and Other Psychiatric Disorders
2. Intra-Cellular Therapies Announces Successful Outcome of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia
3. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007
4. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722
5. Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
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