Navigation Links
Intra-Cellular Therapies Announces the Successful Completion of a Phase Ib/II Study of ITI-007 in Patients with Schizophrenia
Date:7/29/2010

al signals across a broad spectrum of exploratory efficacy measures is also encouraging, especially considering that these patients had clinically stable symptoms at study entry," stated Sharon Mates, Chief Executive Officer of Intra-Cellular Therapies.  "We believe that the favorable clinical profile is consistent with ITI-007's unique pharmacology."

SUMMARY OF ITI-007 PHASE IB/II STUDY RESULTS

The Phase Ib/II study was a randomized, double-blind, placebo-controlled, multiple ascending dose study designed to evaluate the safety, tolerability and pharmacokinetic profile of ITI-007 in patients with stable schizophrenia.  Exploratory endpoints included clinical assessments to evaluate the symptoms of schizophrenia (PANSS) and symptoms of depression (CDSS).  Forty-five patients were randomized to receive ITI-007 or placebo once daily for five days.  Oral doses of ITI-007 up to and including 140 mg were found to be safe and well-tolerated with repeated administration in patients with stable schizophrenia who had been withdrawn from their previous antipsychotic medications.  In an earlier Phase II sleep efficacy trial, low doses of 1-10 mg ITI-007 were shown to significantly improve sleep in patients with insomnia.  In the present study, patients with schizophrenia also anecdotally reported improvements in sleep.  Even at the highest doses of ITI-007 tested, all adverse events were mild to moderate.  Notably, there were no extrapyramidal side effects (EPS) and no cognitive impairment, side effects that are often observed following treatment with other antipsychotic drugs at high doses.  Total cholesterol and triglyceride levels decreased following withdrawal from previous antipsychotic drugs and while being treated with ITI-007.  Pharmacokinetic profiles suggest a once-a-day treatment regimen will be sufficient to achieve
'/>"/>

SOURCE Intra-Cellular Therapies, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Intra-Cellular Therapies Announces the Results of a Phase I PET Study for ITI-007 for the Treatment of Schizophrenia and Other Psychiatric Disorders
2. Intra-Cellular Therapies Announces Successful Outcome of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia
3. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007
4. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722
5. Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
6. Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia
7. Intra-Cellular Therapies Presents Preclinical Data From Schizophrenia and Sleep Maintenance Programs
8. Stakeholder Opinions: HIV in Emerging Markets (Brazil, Russia, India) - Growing need for second- and third-line therapies boosts commercial opportunity
9. Reportlinker Adds Personalized Medicine 2010: Assessing the Opportunities and Challenges in Commercializing Companion Diagnostics and Targeted Therapies
10. TransGenRx Protein Therapeutics Technology to Support Research Related to Protein-Based HDL Therapies at Esperion Therapeutics
11. Drug in New Class of Targeted Therapies Shows Early Promise Against Blood-Related Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... , July 23, 2014 UBM Medica US ... a new online community and information resource for neurologists ... and treat their patients with neurological disorders . ... an aging population, necessitates greater access to dedicated information ... statistics on neurological conditions include: , 1 ...
(Date:7/23/2014)... July 23, 2014 Research and Markets ... Market in Consumer Healthcare by Application, Sensor Type & ... - 2020" report to their offering. ... been an increasing momentum for consumer healthcare monitoring and ... The consumer healthcare will lessen the healthcare cost of ...
(Date:7/23/2014)... Research and Markets  has announced the ... Product, End-user & by Lead Type - Global Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 The global ... segments, namely, holter monitor, resting, and stress type diagnostic ... million in 2013 and is poised to grow at ...
Breaking Medicine Technology:UBM Medica US Launches NeurologyTimes.com 2UBM Medica US Launches NeurologyTimes.com 3Sensor Market in Consumer Healthcare (Patient Monitoring, Therapeutic, Handheld and Homecare, & Fitness and wellness) - Analysis & Forecast to to 2013 - 2020 2Sensor Market in Consumer Healthcare (Patient Monitoring, Therapeutic, Handheld and Homecare, & Fitness and wellness) - Analysis & Forecast to to 2013 - 2020 3Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 2Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 3
(Date:7/23/2014)... if a suspicious skin lesion is painful or itchy ... to be cancerous, according to a new study headed ... Dermatology at Temple University School of Medicine. , The ... July 23, 2014, found that nearly 36. 9 percent ... 28.2 percent involve pain. Non-melanoma skin cancers specifically, ...
(Date:7/23/2014)... Celebrating a decade of philanthropy in 2014, The ... of $1,070,000 in grants to 20 New Jersey non-profit ... Foundation’s 1,000th grant. , “The Horizon Foundation for New ... community-based organizations that are working to improve public health ... State,” said Robert A. Marino, Horizon Blue Cross Blue ...
(Date:7/23/2014)... Inventor and entrepreneur Delegate Joe T. May will ... pump – sharing his passion for technology and innovation ... , With 24 patents granted and three pending, this ... the General Assembly since Thomas Jefferson. Inventions credited to ... seen on television, an instrument for measuring octane on ...
(Date:7/23/2014)... News) -- Regularly checking the pulse of a stroke ... "Screening pulse is the method of choice for checking ... have never had a stroke. Our study shows it ... to identify people who might need more thorough monitoring ... Bernd Kallmunzer, of Erlangen University in Germany. ...
(Date:7/23/2014)... in Shaanxi province, and the University of California, Davis, ... groundwork for establishing the Sino-U.S. Joint Research Center for ... held in the city of Yingchuan, China, during a ... Agriculture and China,s Ministry of Science and Technology. , ... and for our World Food Center and serves as ...
Breaking Medicine News(10 mins):Health News:Research led by Temple's chair of dermatology: Pain and itch may be signs of skin cancer 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 3Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 4Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 5Health News:Celebrating Innovation and Invention 2Health News:Routine Pulse Check May Prevent Second Stroke, Study Says 2Health News:Global food safety research agreement signed by China and UC Davis 2Health News:Global food safety research agreement signed by China and UC Davis 3
... older women need screening as much as younger ones, ... screening should continue for women older than 50 -- ... because they have a similar level of risk as ... suggested there,s little benefit in repeating smear tests in ...
... recovered from unique virus , , THURSDAY, April 23 (HealthDay ... now been diagnosed with a unique form of swine ... people have recovered, Dr. Anne Schuchat, director of the ... for Immunization and Respiratory Diseases, said during an afternoon ...
... EFFINGHAM, Ill., April 23 Heartland Dental Care, Inc. ... care facilities during first quarter 2009.The six acquisitions include ... Phoenix, Ariz., Glendale, Ariz., and New Port Richie, Fla. ... locations in Lee,s Summit, Mo. and Dulles, Va. This ...
... WASHINGTON, April 23 The Food and Drug Administration ... expanded over-the-counter access to the morning-after pill, Levonorgestrel or ... adults. Deirdre McQuade, Assistant Director for Policy and Communications ... Pro-Life Activities, objected to the move in the following ...
... can be significantly reduced by providing a simple intervention ... and alternatives of various imaging modalities, according to a ... Island, NY. , "Given the increased awareness ... medical imaging we hypothesized that a simple intervention of ...
... Minn. -- An important genetic study conducted through ... alcoholism in subjects with European ancestry, according to ... Experimental Research . , Research findings ... specific genes and their variations associated with this ...
Cached Medicine News:Health News:Don't Lower Age for Cervical Cancer Test, Study Urges 2Health News:Swine Flu Cases Now Total 7: CDC 2Health News:Heartland Dental Care, Inc. Adds Eight Dental Practices In First Quarter 2009 2Health News:Pro-Life Spokeswoman Objects to FDA Approval of 'Morning-After Pill' for Minors Without Prescription 2Health News:Mayo clinic study finds gene bringing together animal and human research in alcoholism 2
... custom bars have a large body ... contacts (spaced 3 centimeters center-to-center) to ... repeated cleaning. Polarity indicators are molded ... handle fits our bar electrode styles. ...
... the strongest vacuum force in ... The unit includes a ... plug, footswitch, built-in wheels, retractable ... ring to hold the liquid ...
A system for the removal and filtration of laser and surgical smoke....
Stryker Instruments, the leader in surgical helmets, offers its 4th generation of personal protection systems for todays surgical environment the Sterishield T4 System....
Medicine Products: