Navigation Links
Intra-Cellular Therapies Announces Completion of Phase I Single Rising Dose Trial of First-in-Class Selective Phosphodiesterase 1 (PDE1) Inhibitor and Reports Top-line Safety and Pharmacokinetic Findings
Date:2/19/2013

NEW YORK, Feb. 19, 2013 /PRNewswire/ -- Intra-Cellular Therapies, Inc. ("ITI") today announced the completion of a Phase I single rising dose study of its phosphodiesterase 1 (PDE1) inhibitor, ITI-214.  ITI-214, a novel, first-in-class selective PDE1 inhibitor, was discovered by ITI and is in development under an exclusive collaboration with Takeda Pharmaceutical Company Limited for the treatment of Cognitive Impairment Associated with Schizophrenia (CIAS). 

The primary objectives of the Phase I study were to determine the safety, tolerability and pharmacokinetic profile of single oral doses of ITI-214 in healthy volunteers.  The study was conducted as a randomized, double-blind, placebo-controlled study in 70 subjects.  The results indicated that ITI-214 was safe and well-tolerated across a broad range of single oral doses.  Moreover, ITI-214 demonstrates a favorable pharmacokinetic profile consistent with once-a-day dosing. The study represents a significant milestone as it is the first demonstration of the safety of a PDE1 inhibitor in a Phase 1 clinical trial.

"We are pleased with the advancement of ITI-214 in clinical development," stated Sharon Mates , Ph.D., Chairman and Chief Executive Officer of Intra-Cellular Therapies.  "The data obtained for ITI-214 support its continued development for the treatment of Cognitive Impairment Associated with Schizophrenia and other neuropsychiatric and neurological disorders."

About Schizophrenia

Schizophrenia is a major neuropsychiatric disorder that affects over one percent of the world population with an illness that begins in late adolescence and lasts a lifetime. Its best known symptoms are "positive symptoms", which include hallucinations and delusions; but other mental functions are also affected, including social and motivational skills ("negative symptoms") and cognitive behaviors, like ina
'/>"/>

SOURCE Intra-Cellular Therapies, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Grant Awarded to Study Novel Therapies for Muco-Obstructive Diseases Includes Studies on Cempras Solithromycin (CEM-101) in a Cystic Fibrosis Anti-inflammatory Model
2. Launch Of Premium-priced, Novel Targeted Therapies Will Drive Growth In The Acute Leukemia Markets Beginning In 2015
3. Generex Provides an Overview of its Cancer Immunotherapy Product, AE37, and Potential in Early Breast Cancer Given Current and Potential Future Therapies
4. The Treatment Landscape for Hepatocellular Carcinoma Will Change Dramatically Over the Next Ten Years Due to the Launch of New Therapies in the United States and EU5
5. Oncologists in the United States and Europe Indicate that Novel Chemotherapies Hold the Most Near-Term Promise for Improving Outcomes in Soft Tissue Sarcoma
6. Takeda Receives FDA Approval for Three New Type 2 Diabetes Therapies, NESINA (alogliptin) and Fixed-Dose Combinations OSENI (alogliptin and pioglitazone) and KAZANO (alogliptin and metformin HCl)
7. Oncobiologics and Boston Oncology Team Up to Deliver Biosimilar Therapies for Cancer and Immune Disease to Middle East and North African Markets
8. Chimerix Presents Data Highlighting Burden Of Care Associated With Current Antiviral Therapies In Stem Cell Transplantation
9. Growing Prevalence of Asthma is Fueling Vigorous Industry Competition for Effective, Affordable Therapies
10. Neurostimulation Devices Market to 2018 - Technological Advances and Robust Pipeline with Multi-Indication Potential and Non-Invasive Therapies to Drive Growth
11. Multi-Targeted Therapies - New Wave of Combination Therapies in Late Stage Development for Lung Cancer Offer Promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... September 30, 2014 In a ... (Cerebrospinal Fluid) backflow of the Eldor spinal needle 25G, ... single hole pencil point spinal needles of the same ... Spinal anesthesia is an excellent type of regional ... General Anesthesia, etc. It is estimated that ...
(Date:9/30/2014)... MUNSTER, Ind. , Sept. 30, 2014  The orthopedic ... ranked the nation,s No. 6 orthopedic group by US ... for Active Adults," a series of free, public seminars ... from all over the world come to see the ... replacement procedures are now available at Munster Specialty Surgery ...
(Date:9/30/2014)... Sept. 30, 2014  Arena Solutions, the pioneer ... announced its Fall 2014 release, which includes two ... Arena DataExtract – and significant enhancements ... products are focused specifically on speeding time to ... of a complete history of tribal knowledge throughout ...
Breaking Medicine Technology:"Knee Pain Solutions for Active Adults" Complimentary Seminars Open to the Public 2Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 2Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 3Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 4
... governmental markets still depressed, Allied Healthcare Products (Nasdaq: AHPI ... year 2011 and improvement in its year-over-year performance. ... 1 cent per basic and diluted share, compared to $22,000, or ... first two quarters of the fiscal year, net income was about ...
... Feb. 8, 2011 Actavis Group, an international generic ... from the US Food & Drug Administration to market ... will commence shortly.   Pantoprazole Sodium Delayed-Release ... 20mg and 40mg by Pfizer, had US sales of ...
Cached Medicine Technology:Allied Healthcare Products Reports Modest Profit for Quarter 2Allied Healthcare Products Reports Modest Profit for Quarter 3Allied Healthcare Products Reports Modest Profit for Quarter 4Actavis Receives Approval of Pantoprazole Sodium Delayed-Release Tablets, USP in the U.S. 2
(Date:9/30/2014)... -- There,s no genetic evidence that high levels of ... study says. Some previous research had suggested that ... type 2 diabetes, raising the possibility of a link ... In this study, British researchers investigated the association ... genes that control blood levels of vitamin D. They ...
(Date:9/30/2014)... HealthDay Reporter TUESDAY, Sept. 30, ... to put the brakes on motherhood. And for many young ... choice, new research suggests. Women in their early 20s ... during tough economic times. But, according to the new study, ... their 40s and beyond. The findings suggest that higher ...
(Date:9/30/2014)... Health Day Reporter TUESDAY, Sept. ... are overweight or obese when diagnosed appear to face ... cancer, new research suggests. , , The finding didn,t ... the potential for developing other cancers associated with obesity. ... reported being overweight or obese prior to diagnosis had ...
(Date:9/30/2014)... PROVIDENCE, R.I. [Brown University] Autism is no stranger ... the East African nation is access to clinical services, ... autism diagnostic measure, for example, validated for use in ... small new study, however, researchers at Brown University and ... diagnostic approach that they implemented at two sites in ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 A new ... State University studied the impact of stress on metabolism after ... and french fries from a fast food restaurant, about 930 ... resting metabolism for 20 minutes every hour for 7 hours, ... showed that women who had experienced a stressful event in ...
Breaking Medicine News(10 mins):Health News:Gene Study Finds No Proof Vitamin D Guards Against Type 2 Diabetes 2Health News:Recessions May Thwart a Woman's Motherhood Plans Forever: Study 2Health News:Recessions May Thwart a Woman's Motherhood Plans Forever: Study 3Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 2Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 3Health News:New diagnostic approach for autism in Tanzania 2Health News:New diagnostic approach for autism in Tanzania 3Health News:New diagnostic approach for autism in Tanzania 4Health News:NutriGold Urges Every Woman To Read a Recent Study About Diet and Stress 2Health News:NutriGold Urges Every Woman To Read a Recent Study About Diet and Stress 3
... Medicine researchers have found that intensively controlling glucose (glycemic) levels ... kidney failure. The study, which is a review of data ... issue of Archives of Internal Medicine . ... renal disease in patients with type 2 diabetes mellitus, first ...
... should enable them to detect signs of a disease in ... Nature Materials . The scientists, from Imperial ... test to detect particular molecules that indicate the presence of ... are already tests available for some diseases that look for ...
... Americans with individual market health insurance coverage in 2010 were ... the lowest "bronze"-level plans in the Affordable Care Act, and ... health insurance exchanges that are being created under the law, ... Web First in the journal Health Affairs . The ...
... Reporter , FRIDAY, May 25 (HealthDay News) -- Doctors have ... relief in physical pain -- cutting or burning or sticking ... But researchers now are questioning whether enough is being done ... before they do themselves irreparable damage. One study this ...
... its epidermal growth factor receptor cousins mobilize a specialized protein ... metabolism, scientists report in the May 25 issue of ... promotes Herceptin resistance in breast cancer and activation of glucose ... their growth and survive. Their research focused on Skp2 ...
... 25 (HealthDay News) -- Exposure to loud music at a ... researchers say. A small study by the House ... hearing after attending a three-hour show. This type of hearing ... repeatedly, permanent hearing loss can develop, the study authors noted. ...
Cached Medicine News:Health News:Super-sensitive tests could detect diseases earlier 2Health News:Half of Americans with individual health plans could gain better coverage under the ACA 2Health News:Half of Americans with individual health plans could gain better coverage under the ACA 3Health News:Half of Americans with individual health plans could gain better coverage under the ACA 4Health News:More Mental Health Care Urged for Kids Who Self-Harm 2Health News:More Mental Health Care Urged for Kids Who Self-Harm 3Health News:Skp2 activates cancer-promoting, glucose-processing Akt 2Health News:Skp2 activates cancer-promoting, glucose-processing Akt 3Health News:Can You Hear Me Now? 2
... spectrophotometer designed specifically to run 24 hours ... rugged hardware, proven optical performance and a ... traditional spectrophotometry to obtain results quickly, accurately ... up to eight, 1 cm Biocell cuvettes ...
The PerkinElmer LS 45 Luminescence spectrometer offers versatility, reliability and ease-of-use for routine analyses in an affordable package....
... a new generation Spectrophotometer for near ... nm to 1020 nm with built-in ... and printer. It features four digit ... transmittance, absorption and concentration with excellent ...
... UV/visible spectrophotometers provide ease-of-use and proven technology ... DU Series 800 high-performance spectrophotometers with microfocused ... as small as 5 l. The DU ... intended for use in quantitative and qualitative ...
Medicine Products: