Navigation Links
International Team Locates Key Player in Muscle Regeneration
Date:6/27/2008

PHILADELPHIA, June 27 /PRNewswire-USNewswire/ -- A new understanding of the role played by the protein cdk9-55 in muscle regeneration and differentiation may lead to novel therapies to rebuild muscle tissue damaged by disease, injury and aging, according to researchers at the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia and the University of Siena.

The researchers reported their findings, "Cdk9-55: A New Player in Muscle Regeneration" in the Journal of Cellular Physiology (http://www.ncbi.nlm.nih.gov/pubmed/18546201?dopt=Abstract).

Adult skeletal muscle tissue can regenerate in response to direct injury, neurological dysfunction and genetic defects. This healing process begins with an activation of muscle stem cells, known as satellite cells. Once activated, the satellite cells multiply and then differentiate into specific types of muscle fibers that eventually fuse to reconstitute muscle tissue.

The researchers discovered that cdk9-55, a variation of the gene cdk9, is induced specifically when satellite cells begin differentiation and is necessary for the genetic reprogramming required to complete the muscle tissue regeneration process.

"By administering cdk9-55 or a protein encoded by a cdk9-55 gene directly to the muscle or on a resorbable material applied to injured or diseased muscle tissue or to an area missing muscle tissue, we can regenerate muscle," said lead researcher Cristina Giacinti, a researcher at the Sbarro Institute and the Department of Histology and Medical Embryology, University of Rome "Sapienza" in Rome, Italy.

Researchers also found that cdk9-55 can be used to increase muscle tissues in healthy tissue.

"This discovery has important implications for tissue regeneration in muscle tissue damaged by disease and injury, genetic disorders such as muscular dystrophy, chronic disorders like cancer or HIV that may impair muscle regeneration, and diseases related to aging," said Antonio Giordano, M.D., Ph.D., the Director of the Sbarro Institute, President of the Sbarro

Health Research Organization, Professor of Molecular Biology at Temple University's College of Science and Technology in Philadelphia, PA, and full professor Pathological Anatomy and Histology of the University of Siena, Italy.

The Sbarro Health Research Organization (http://www.shro.org) and the National Institutes of Health supported the study.

About the Sbarro Health Research Organization

Sbarro Health Research Organization is committed to excellence in basic genetic research to cure and diagnose cancer, cardiovascular diseases, diabetes and other chronic illnesses and to foster the training of young doctors in a spirit of professionalism and humanism.

This news release was issued on behalf of Newswise(TM). For more information, visit http://www.newswise.com.


'/>"/>
SOURCE Sbarro Health Research Organization
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
2. Paper in International Journal of Oncology Reports Alfacells ONCONASE(R) Suppresses Intracellular Oxidative Stress
3. Ozarelix Phase 2 Data Presented at 29th Congress of the Societe Internationale dUrologie
4. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
5. International Expert Group Initiates Largest Multi-center Phase III Trial to Evaluate NeuroAid(TM) in Stroke Recovery
6. Surface Logix Presents Positive Phase 1 Repeat-Dose Trial Data on SLx-4090 at The 16th International Symposium on Drugs Affecting Lipid Metabolism
7. Preclinical Data on Lead MEK Inhibitor, RDEA119, to be Presented at the 2007 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
8. Tumor Growth Inhibition and Pharmacokinetic Profile of NKTR-102 (PEG-Irinotecan) in Multiple Solid Tumors To Be Presented at Upcoming AACR-NCI-EORTC International Conference
9. Preimplantation Genetic Diagnosis International Society Refutes American Society of Reproductive Medicine Opinion - States Preimplantation Genetic Screening is Beneficial When Performed in Experienced Centers
10. Survival Data for Avicenas Amyotrophic Lateral Sclerosis Drug Candidate, AL-02, to be Presented at 18th International Symposium on ALS/MND
11. CEL-SCI CEO to Present at the International Society for Pharmaceutical Engineering 2007 Chesapeake BioShowcase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... 24, 2016 According to a ... (Standard Pen Needles, Safety Pen Needles), Needle Length (4mm, ... Hormone), Mode of Purchase (Retail, Non-Retail) - Trends & ... studies the market for the forecast period of 2016 ... 2.81 Billion by 2021 from USD 1.65 Billion in ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
Breaking Medicine Technology:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... ... Comfort Keepers® of San Diego, CA is excited to announce they are ... drive cancer patients to and from their cancer treatments. Comfort Keepers provides quality ... and ongoing independence. Getting to and from medical treatments is one of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the ... in the world, and the most handsome men, look naturally attractive. Plastic surgery ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Venture Construction ... Classic Tournament held on June 20th at the Woodmont Country Club at 1201 ... Wings, an organization dedicated to helping service members that have been wounded in battle ...
Breaking Medicine News(10 mins):