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International St. Gallen Expert Panel Highlights Importance of Molecular Subtyping in Breast Cancer Treatment
Date:8/10/2011

IRVINE, California and AMSTERDAM, August 10, 2011 /PRNewswire/ --

Agendia, a commercial-stage molecular cancer diagnostics company, today announced that the 12th St. Gallen International Breast Cancer Conference (2011) Expert Panel's recommendations highlight the value of molecular subtyping - classifying patients by the particular biological subtype of their tumor - in guiding treatment decisions for breast cancer patients. According to the panel, "it is no longer tenable to consider breast cancer as a single disease" and clinicians "should consider cases within the various distinct subtypes in order to properly assess the relevant evidence and arrive at appropriate therapeutic advice." The panel's updated guidelines, which are released on a semiannual basis, appear in the August 2011 issue of Annals of Oncology in an article titled "Expert Consensus on the Primary Therapy of Early Breast Cancer 2011" by Goldhirsch, et al (Annals of Oncology 22: 1736-1747, 2011).

The panel's recommendations support the clinical value of Agendia's BluePrint assay, which, in combination with the company's FDA-cleared MammaPrint® recurrence test, can accurately classify all patients as Basal, Luminal-A, Luminal-B, or ERBB2 (HER2) and help determine appropriate treatment. Both clinically available, MammaPrint and BluePrint are two components of Agendia's Symphony™ suite of breast cancer treatment products, a comprehensive collection of genetic assays that help address complex treatment decisions for any type and stage of breast cancer.

The panel also recognized that MammaPrint provided such accurate prognoses that patients and physicians may decide that chemotherapy is not required. MammaPrint identifies patients' risk of metastasis, placing them into one of just two groups, high risk and low risk. Women in the low risk group are able to be treated effectively and safely without undergoing chemotherapy and its side effects.

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SOURCE Agendia B.V.
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