Interleukin Genetics to Present Important New Findings at 2008 World Congress on Oste...(UniversityHospital for Joint Diseases an...),Health

Date:9/15/2008

University Hospital for Joint Diseases and Dr. Virginia Byers Kraus of the Duke University Medical Center. The studies evaluated a broad range of gene variations in OA populations from both institutions. Three commonly occurring variations in the gene for IL-1 receptor antagonist were found to be strongly and significantly associated with severe knee OA, as measured on radiographs.

In addition, variations in three separate genes involved in inflammation were found to predict which knee OA patients are more likely to develop OA in their hands, a more generalized form of the disease that adds further complications to the patient's daily activities.

About Osteoarthritis

Osteoarthritis is a debilitating, degenerative joint disease and the leading cause of physical disability in modern societies. According to data on the American College of Rheumatology website, approximately 21 million adults in the U.S. have joint pain and limited movement consistent with a diagnosis of OA. It has been estimated that 45 percent of adults will develop knee OA as they age. Many OA patients experience minimal changes in their symptoms over time and manage their disease symptoms for many years with non- prescription pain medications. A substantial number of other patients will develop severe destruction of the bone and joint tissues leading to compromised physical activity and more generalized disease affecting the hands. Severe structural deterioration impairs the quality of life and often leads to disability and joint replacement. In the U.S. approximately 500,000 patients received joint replacement surgery in 2007. There are currently no drugs approved for modifying disease progression of OA, but several drugs are in mid-to-late stages of development.

About the Studies to be Reported at OARSI

Adults with confirmed knee OA were analyzed for genetic variations involved in inflammation and in regulating the status of cartilage and bone tissues that compo
'/>"/>

SOURCE Interleukin Genetics, Inc. Copyright©2008 PR Newswire. All rights reserved

0 GOOD

Page: 1 2 3 4
Related medicine technology :

1. Interleukin Genetics Wins International Award for Outstanding Research Published in the Journal, Nutrition
2. Interleukin Genetics Launches Enhanced Heart Health Genetic Test Report Format
3. Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics Heart Health Test
4. Genaera Announces MedImmune Initiation of Phase 2a Trial of Antibody Targeting Interleukin-9 in Patients with Asthma
5. MedImmune Advances Clinical Development of Antibody Targeting Interleukin-9 in Patients with Asthma
6. Phase 2a Multi-Dose Study Initiated by MedImmune in Patients With Asthma to Further Expand Anti-Interleukin-9 Program
7. Boston University and The Center for Human Genetics, Inc. Announce Change in Testing Services
8. New Research Provides Evidence that Tea May Improve Attention and Focus, Keep Brain Cells Healthy, & Influence Genetics in Cancer
9. Targeted Genetics Announces Positive Phase 1/2 tgAAC94 Data Presented at Annual European Congress of Rheumatology
10. CellCyte Genetics Corporation Selects Washington University School of Medicine to Perform Study on CellCytes Glycoprotein Products in Heart Attack Disease Model
11. CellCyte Genetics Signs Collaborative Agreement With Northwestern Universitys Feinberg School of Medicine to Perform Disease Model Outcome Study of CellCytes CCG-TH30 Product Candidate