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Interleukin Genetics and NYU Langone Medical Center Announce Publication of Study on Genetics of Osteoarthritis
Date:12/2/2009

om NYU Langone Medical Center's Hospital for Joint Diseases and the other from Duke University Medical Center. Fifteen SNPs in six inflammatory genes were evaluated for association with radiographic severity and with synovial fluid collected from a subset of the patients.

All 130 patients met clinical symptomatic criteria and radiographic criteria for OA of at least one affected knee and were over age 38. Patients with histories of corticosteroids, bilateral knee replacements, other forms of arthritis, cancer, or other chronic diseases beyond hypertension or hypercholesterolemia were excluded.

Results of the study showed interleukin-1-receptor antagonist (IL1RN) single-nucleotide polymorphisms (rs419598; rs315952; and rs9005) predicted Kellgren-Lawrence scores independently in each population. One IL1RN haplotype was associated with lower odds of radiographic severity (OR 0.16; 95% CI 0.06-0.40), greater joint space width (JSW; p=0.0038), and lower synovial fluid cytokine levels. Carriage of the IL1RN haplotype influenced the age relationship with severity.

IL1RN Polymorphisms reproducibly contribute to disease severity in knee OA and may be useful biomarkers for patient management by physicians and in the selection of patients in disease modifying OA drug trials.

About Interleukin Genetics

Interleukin Genetics, Inc. (NYSE Amex: ILI) develops and markets genetic tests that empower consumers to prevent chronic diseases of aging and that assist pharmaceutical companies in the development and marketing of targeted therapeutics. The Company leverages its research, intellectual property and biomarker development experience to facilitate the emerging personalized health market. Interleukin Genetics is headquartered in Waltham, MA. For more information please visit

SOURCE Interleukin Genetics, Inc.
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