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Interleukin Genetics Presents Research Linking Vertebral Fractures to Gene Variations in Asian Women With Osteoporosis
Date:4/1/2009

WALTHAM, Mass., April 1 /PRNewswire-FirstCall/ -- Interleukin Genetics, Inc. (NYSE Amex: ILI), announced today that the company will present research findings from a large clinical study on the genetics of osteoporosis and vertebral fractures at the 8th International Symposium on Osteoporosis: Translating Research into Clinical Practice, on April 4, 2009 at the Marriott Wardman Park Hotel in Washington, D.C. The Company's research poster, titled "Identification of Inflammatory Gene Variants as Biomarkers of Osteoporosis Risk in Asian Women," highlights genetic predisposition risk factors in Asian women for vertebral fractures and osteoporosis and will be presented at 9:45 a.m. in Exhibit Hall C.

The cross-sectional study evaluated over 1,200 Korean and Japanese female subjects. Predisposition for vertebral fracture and elevated bone biomarkers were investigated in candidate genes linked to osteoporosis, with statistical adjustments made for known risk factors such as age, body mass index and drug treatment. The research found Korean women in the study were seventy percent more likely to get vertebral fracture if they carried a genetic variation, also called single nucleotide polymorphism (SNP), in the IL-10 gene, while those who carried a SNP in the IL1-RN gene were fifty percent more predisposed to vertebral fracture. The study results also revealed differences in genetic markers between Asian and Caucasian post-menopausal women, despite high susceptibility for disease among both populations.

The study, which was conducted in collaboration with Yonsei University in Seoul, Korea, enrolled a sample of 838 Korean women between the ages of 60 to 84 years and 400 Japanese women within 36 months post-menopause.

"While studies exist that look at the genetics of osteoporosis, there has been minimal re
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SOURCE Interleukin Genetics, Inc.
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