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Interim Results Reported for Phase I Open-Label Clinical Trial for the Treatment of PTSD and MDD Using External Trigeminal Nerve Stimulation (eTNS™) - The USB Port to the Brain™
Date:5/30/2012

LA's TNS intellectual property, including eTNS for PTSD and depression.  Dr. Ian Cook added, "I'm confident that the transfer of the technology from academia to the next phase of trials will go smoothly and that, with replication, this treatment has the opportunity to be made available to help many of those who suffer with PTSD and major depression.  Given the external, non-invasive nature of this therapy, it might be useful in the battlefield or in an emergency room immediately after a traumatic event, with the theoretical potential to impact the development of full-blown PTSD."

Background - TNS
NeuroSigma is commercializing two embodiments of trigeminal nerve stimulation (TNS): eTNS™ (external electrodes and an external pulse generator) and sTNS™ (subcutaneous electrodes and implantable pulse generator).  The eTNS system utilizes a self-adhesive conductive pad applied to the forehead to stimulate branches of the trigeminal nerve, which are located very close to the surface of the skin in the forehead.  The trigeminal nerve is the largest cranial nerve, offering a high-bandwidth pathway for signals to enter the brain.  In clinical studies, eTNS is well tolerated and the low-energy stimulus is confined to the soft tissues of the face without direct penetration into the brain – hence the term "USB Port to the Brain™."

The trigeminal nerve projects to specific areas of the brain, such as the locus coeruleus, nucleus tractus solitarius, thalamus and the cerebral cortex, which are involved in epilepsy, depression, PTSD and other disorders.  PET imaging studies in humans confirms that eTNS activates or inhibits key regions implicated in these disorders and the changes were observed within minutes of therapy.  Once approved by regulatory agencies, patients who respond well to eTNS can opt to switch to the implantable sTNS system.  NeuroSigma has completed development of its eTNS syst
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SOURCE NeuroSigma
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