Navigation Links
Interim Phase 1/2 Data of Ipilimumab in Prostate Cancer Presented at American Society of Clinical Oncology Annual Meeting
Date:6/2/2008

ion resistant prostate cancer and bone metastases, and these data encourage further exploration of the ability of tumor antigen release by radiotherapy to serve as an immune-supportive intervention in combination with ipilimumab as a potentially important treatment option for these patients."

The Phase 1/2 trial was conducted to evaluate the safety and preliminary anti-tumor activity of escalating doses of ipilimumab (3, 5 or 10 mg/kg) every three weeks for up to four doses, with and without a single dose of focal radiotherapy administered to target bone lesion(s) prior to the first dose of ipilimumab. The dose escalation portion of the trial enrolled 33 patients with mCRPC and with bone metastases. Additional patients are enrolling in the expansion cohort of 10mg/kg ipilimumab in combination with radiotherapy.

Adverse events related to ipilimumab in this study were generally manageable and consistent with those immune-related adverse events (irAEs) previously reported in other clinical trials of ipilimumab. Grade 3/4 adverse events included diarrhea/colitis (5 patients), rash (1 patient) and elevated liver enzymes (2 patients). No new patterns or frequency of adverse events emerged in patients receiving the combination of ipilimumab and radiotherapy.

About Ipilimumab

Ipilimumab is a fully human antibody that binds to CTLA-4 (cytotoxic T lymphocyte-associated antigen 4), a molecule on T-cells that plays a critical role in regulating natural immune responses. The absence or presence of CTLA- 4 can augment or suppress the immune system's T-cell response in fighting disease. Ipilimumab is designed to block the activity of CTLA-4, thereby sustaining an active immune response in its attack on cancer cells.

Comprehensive Clinical Trial Program for Ipilimumab

Bristol-Myers Squibb Company and Medarex remain committed to the development of ipilimumab. The companies also have ongoing Phase 2 studies in hormone-refractory prostate canc
'/>"/>

SOURCE Medarex, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. AMT Announces Positive Interim Clinical Data on its Lead Product AMT-011
2. Sunesis Pharmaceuticals to Present Interim Clinical Data From Voreloxin (Formerly SNS-595) Ovarian Cancer Trial at 44th ASCO Annual Meeting and Acute Myeloid Leukemia Trials at 13th EHA Congress
3. Significant Anti-Tumor Activity of NKTR-102 in Patients With Refractory Solid Tumors; Interim Data Published in ASCO 2008 Proceedings
4. Alseres Pharmaceuticals Announces 12 Month Interim Results from the Phase I/IIa Cethrin(R) Clinical Trial in Acute Spinal Cord Injury
5. Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL
6. Interim Analysis of Phase I/II Study of Rexin-G Confirms Efficacy With No Dose Limiting Toxicity in Metastatic Pancreatic Cancer
7. Medarex Reports Interim Data from Ongoing Ipilimumab Combination Phase 1 Studies in Prostate Cancer at American Association for Cancer Research Meeting
8. Nventa Announces Positive Interim Immunological Data From HspE7 Phase 1 Cervical Dysplasia Trial
9. NanoBio Corporation Completes Interim Analysis of Phase 2 Clinical Trial in Onychomycosis
10. Independent Data Safety Monitoring Board Recommends Continuation of Sangarts Pivotal Phase III Trials of Hemospan(R) Following Second Interim Review
11. Sunesis Pharmaceuticals Reports Positive Interim Data for SNS-595 Single-Agent Activity in Platinum-Resistant Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)...   Royal Philips (NYSE: ... of its portfolio of diagnostic X-ray solutions ... , ProGrade and PrimaryDiagnost[ii]. With new releases of ... U.S., and availability of all these solutions in ... innovative solutions designed to meet the needs and ...
(Date:11/26/2014)... 2014 Lexicon Pharmaceuticals, Inc. (Nasdaq: ... previously announced concurrent financing transactions resulting in gross ... offering expenses, Lexicon anticipates net proceeds of approximately ... of: , a public offering of ... registration statement that has been declared effective by ...
(Date:11/26/2014)... -- Scott Steiger lives in St. Louis ... engineer for the past 20 years, he,s traveled extensively and prior ... been to six of the seven continents. Travel is a big ... Photo - http://photos.prnewswire.com/prnh/20141126/161077 So when ... good idea of what,s required. His latest creation is ...
Breaking Medicine Technology:Philips expands global reach of diagnostic X-Ray solutions 2Philips expands global reach of diagnostic X-Ray solutions 3Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3Steiger Has Created the First Pill Case Specifically Designed For Travel 2
... CVS Caremark (NYSE: CVS ) today ... of CVS/pharmacy effective October 1, 2011.  With more than ... and Puerto Rico, CVS/pharmacy is one of the largest ... http://photos.prnewswire.com/prnh/20090226/NE75914LOGO) Cosby, 52, most recently served as ...
... Oncobiologics, Inc. and Fox Chase Cancer Center ... next-generation bi-specific antibody cancer platform with enhanced therapeutic ... is designed to handle multiple targets, representing a ... is now underway, with preclinical studies expected in ...
Cached Medicine Technology:CVS Caremark Appoints Mark S. Cosby as President of CVS/pharmacy 2CVS Caremark Appoints Mark S. Cosby as President of CVS/pharmacy 3Oncobiologics, Inc. and Fox Chase Cancer Center Announce Co-Development of a Novel Cancer Therapy Platform 2Oncobiologics, Inc. and Fox Chase Cancer Center Announce Co-Development of a Novel Cancer Therapy Platform 3
(Date:11/28/2014)... Now that the holiday season is ... the nation's leading cash-for-junk-cars companies, is improving their cash ... more competitive and help bring a little bit more ... of year. , Along with purchasing expensive gifts for ... also deal with large travel expenses during the holiday ...
(Date:11/28/2014)... On Monday, November 24, 2014, just ... Feeding America Eastern Wisconsin with a check for over ... a portion of proceeds to Feeding America Eastern Wisconsin. ... 7 Ways to Save” with Turbana bananas and Fyffes ... for $4 and Turbana bananas were 29 cents per ...
(Date:11/28/2014)... FL (PRWEB) November 28, 2014 Miami's ... responsive website. Practice founder Dr. Jeffrey Epstein ... Created using a groundbreaking WordPress platform, the site ... , Currently, up to 75% of all ... than ever, these people are logging on with smartphones, ...
(Date:11/28/2014)... Evergreen, Colorado (PRWEB) November 28, 2014 Written ... Jackson , Brook Forest Voices releases the “The Happiest ... audiobook , a compelling account of how and why Project ... of Idaho by his mother Josie and the Reverend Richard ... millionaire by the age of 30, but realized that he ...
(Date:11/28/2014)... Not only is the Éminence Organic Skin Care ... and other cancer-causing agents, but they are also proud ... programs that help in the fight against breast cancer. ... incredible, record-breaking contribution of $30,000 through participation in the ... Red Rose Whip Moisturizer and the company’s corporate donation. ...
Breaking Medicine News(10 mins):Health News:Rusty's Auto Salvage Increasing Their Cash Offers to Help Drivers Save Throughout the Busy Holiday Season 2Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 2Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 3Health News:Top Rhinoplasty Surgeon Launches Innovative Website 2Health News:Thanksgiving Weekend Audiobook Treat! “The Happiest Man In the World: Life Lessons From a Cultural Economist” by Dr. James W. Jackson 2Health News:Éminence Organic Skin Care Donates Record-breaking $30,000 to Breast Cancer Research 2Health News:Éminence Organic Skin Care Donates Record-breaking $30,000 to Breast Cancer Research 3
... a chlorine gas disaster in a South Carolina town gives ... how to prepare emergency response systems for an accidental or ... now available in the January 2009 issue of the ... one of the largest community exposures to chlorine gas since ...
... of chronic abdominal pain of luminal etiology is a ... The exact localization of lesion to either small or ... In tropical countries, where most of the population is ... which screens small and large bowel lesions simultaneously at ...
... 29 Stereotaxis, Inc.,(Nasdaq: STXS ) today ... existing institutional investors to raise gross proceeds of $20,million ... two separate,concurrent transactions. A portion of the warrants sold ... these warrants would provide an additional,approximately $10 million in ...
... study finds , , MONDAY, Dec. 29 (HealthDay News) -- ... have sex as teens who don,t make such promises -- ... disease or pregnancy, a new study finds. , "Previous studies ... than non-pledgers," said study author Janet E. Rosenbaum, a post ...
... 5k Walks Drive Home Importance of Awareness and Education ... an effort to raise money for The Kidney TRUST(TM) ... of chronic kidney disease (CKD) -- DaVita Inc., the ... that the 3rd annual "Kidney Awareness Time(TM)" Walk-a-thon (The ...
... Free Company Plans New Products and Expanded Services in 2009 ... ... Vista, LLC has reported its seventh consecutive year of revenue growth ... and strong demand for media relations and marketing services provided by ...
Cached Medicine News:Health News:New study examines effects of Graniteville, S.C., chlorine gas disaster 2Health News:New study examines effects of Graniteville, S.C., chlorine gas disaster 3Health News:A new screening test for chronic abdominal pain 2Health News:Stereotaxis to Raise $20 Million in Registered Direct Offering of Common Stock and Warrants 2Health News:Stereotaxis to Raise $20 Million in Registered Direct Offering of Common Stock and Warrants 3Health News:Stereotaxis to Raise $20 Million in Registered Direct Offering of Common Stock and Warrants 4Health News:Many Teens Don't Keep Virginity Pledges 2Health News:Many Teens Don't Keep Virginity Pledges 3Health News:Thousands of DaVita Teammates Raise Over $100,000 for CKD Programs 2Health News:Thousands of DaVita Teammates Raise Over $100,000 for CKD Programs 3Health News:Fisher Vista, LLC Reports Seventh Consecutive Year of Revenue Growth and Profitability 2Health News:Fisher Vista, LLC Reports Seventh Consecutive Year of Revenue Growth and Profitability 3
... contact between grant material and fracture ends ... bones., ,Grid-Like Format of Mesh Cathode Provides ... , ,The innovative Mesh Cathode of the ... and a scaffolding effect designed to increase ...
Flowmate makes portable uroflowmetry easy, accurate and dignified. Flowmate has automatic start and stop as well as simple and straightforward reporting from its own printer....
... a single use device that produces rapid, ... spread and vapor sealing of adjacent tissue ... BPH, without deep desiccation. Often referred to ... the Plasma-V gives the urologist the control ...
Sterile Disposable Thermal Cautery Tips for Vasectomy. Individually peel-pouched with dual plastic sheaths to cover non-sterile handle. Box of 10 tips....
Medicine Products: