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Interim Phase 1/2 Data of Ipilimumab in Prostate Cancer Presented at American Society of Clinical Oncology Annual Meeting
Date:6/2/2008

PRINCETON, N.J., June 2 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX) today announced interim results from a Phase 1/2 trial of ipilimumab, an investigational oncology immunotherapy, as monotherapy or in combination with radiotherapy in patients with metastatic castration resistant prostate cancer (mCRPC). Data presented showed that ipilimumab monotherapy or in combination with radiotherapy was clinically active and generally well-tolerated. Preliminary evidence of anti-cancer activity showed that 21 percent of patients (7 of 33) experienced decreases in prostate-specific antigen (PSA) serum levels of over 50 percent, with median duration of PSA responses of 4.8 months. This included one patient treated at the highest dose with a complete response (measured by both PSA and RECIST criteria) ongoing over one year. Two additional patients had PSA reductions of more than 30 percent within 12 weeks of treatment. The interim results were described in an oral presentation by investigator Tomasz M. Beer, M.D., the Grover C. Bagby Endowed Chair for Prostate Cancer Research and Associate Professor of Medicine from Oregon Health & Science University Cancer Institute, at the annual meeting of the American Society of Clinical Oncology (ASCO) being held in Chicago. (Abstract #5004)

"These initial data in patients with metastatic castration resistant prostate cancer demonstrated preliminary anti-tumor activity, including durable response, and is suggestive of a safety profile at the optimal ipilimumab regimen similar to that observed in our melanoma program," said Geoffrey M. Nichol, MBChB, Senior Vice President of Product Development at Medarex. "Radiotherapy is routinely used for palliative treatment in patients with metastatic castrat
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SOURCE Medarex, Inc.
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