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Interim Data Announced for BIBF 1120 as Compared to bevacizumab in Combination Chemotherapy in Metastatic Colorectal Cancer
Date:9/27/2011

allow us to move forward and to investigate BIBF 1120 in patients with advanced colorectal carcinoma enabling us to further explore this potential additional treatment option," said Christopher Corsico, M.D., M.P.H., Sr. Vice President, Medicine and Regulatory, Boehringer Ingelheim Pharmaceuticals, Inc. "BIBF 1120 is another example of Boehringer Ingelheim's continued commitment to advancing oncology research by investigating our compounds in a variety of tumor types."

BIBF 1120 is an investigational orally-administered triple angiokinase inhibitor that targets three of the receptor tyrosine kinases shown to aid in the regulation of angiogenesis, or the formation of blood vessels: fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR).(3)

About Trial Nr. NCT 00904839

Abstract Details

  • Abstract title: A Phase I/II, Open-label, Randomised Study of BIBF 1120 Plus mFOLFOX6 Compared to Bevacizumab Plus mFOLFOX6 in Patients with Metastatic Colorectal Cancer  
  • Abstract number: 14LBA
  • Speaker:  Van Cutsem, E. (B)
  • Session being presented: Presidential Session IV: Best and Late Breaking Abstracts
  • Location: Hall A1    
  • Date: September 27, 2011, 3:00 – 5:00 a.m. EDT

The primary objective of this Phase I/II study is to evaluate PFS rate at 9 months of patients receiving BIBF 1120 in combination with mFOLFOX6 compared to patients receiving bevacizumab combined with mFOLFOX6 in first line metastatic colorectal cancer.(4)  The 9-month PFS rate was defined as the percentage of patients whose disease did not progress or who did not die 9 months after the treatment had started.(4)

About Colorectal Cancer

Although mortality rates for colorectal cancer in the U.S. have declined over the past two decades,
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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