Navigation Links
Interim Data Announced for BIBF 1120 as Compared to bevacizumab in Combination Chemotherapy in Metastatic Colorectal Cancer
Date:9/27/2011

STOCKHOLM, Sept. 27, 2011 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. today announced interim results from an exploratory clinical trial evaluating its investigational compound BIBF 1120 in patients with metastatic colorectal cancer (mCRC).  In this Phase I/II study of 126 patients comparing BIBF 1120 as first-line treatment to bevacizumab, both in combination with mFOLFOX6 (6th modified regimen of folinic acid [leucovorin], fluorouracil, and oxaliplatin), the progression-free survival (PFS) rate at 9 months was 63 percent (95% CI: 50%-75%) in the BIBF 1120 arm and 69% (95% CI: 53%-86%) in the bevacizumab arm.(1)  The median PFS was numerically similar between both groups at 10.6 months ([95% CI: 9.4-12.3] for the BIBF 1120 arm and [95% CI: 9.1-NA] for the bevacizumab arm).(2)

The study, presented at the Presidential Session of the 2011 European Multidisciplinary Cancer Congress in Stockholm, Sweden, also showed that the objective response rate (ORR), a measure of tumor shrinkage, was 61 percent in the BIBF 1120 arm and 54 percent in the bevacizumab arm.(1)

While both treatment arms showed similar safety profiles, a lower incidence of serious adverse events was seen in patients taking BIBF 1120 compared to those taking bevacizumab (34% vs. 54%).(2)  Adverse events (grade 3 or higher) experienced by at least 10 percent of patients in the BIBF 1120 and bevacizumab arms included neutropenia (32% vs. 24%), diarrhea (15% vs. 12%), neurotoxicity (14% vs. 10%), paresthesia (13% vs. 12%) and asthenia (11% vs. 10%).(1)  Patients receiving BIBF 1120 experienced a lower frequency of serious gastrointestinal adverse events than those receiving bevacizumab (12% vs. 29%).(2)

The study is ongoing in order to collect overall survival (OS) data. Phase III trials with larger patient populations will be considered to confirm these results and to further investigate the potential of BIBF 1120 in mCRC.

"The study results
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
2. Interim Response and Safety Analyses Support Continuation of Allos Therapeutics Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-Cell Lymphoma
3. Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial
4. Interim Safety Data Favorable for Vicals Phase 2 Trial of DNA Vaccine Against CMV
5. Interim Phase 2 Data for Exelixis XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer
6. Leading Physicians Present Interim Results from Multi-Center Studies of VNUS ClosureFAST Catheter at VEITHsymposium
7. Grantees of the Avon Foundation Breast Cancer Prevention Research Initiative Gather in Houston to Report Interim Findings
8. Novavax Announces Favorable Interim Results from Human Clinical Trial for Its Pandemic Influenza Vaccine Program
9. Interim Safety Analysis Supports Continuation of Allos Therapeutics Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma
10. Interim Analysis Supports Continuation of Cell Genesys VITAL-1 Phase 3 Clinical Trial of GVAX Immunotherapy for Prostate Cancer
11. NanoBio Corporation Presents Preclinical and Interim Clinical Data on Topical Treatments for Herpes Labialis and Onychomycosis at AAD 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 16, 2014 This report analyzes the worldwide markets ... Segments: Parasiticides, Vaccines, Anti-Infectives, Medicinal Feed Additives, and Others. The ... Farm Animals. The report provides separate comprehensive analytics for the ... , Europe , Asia-Pacific ... World. Annual estimates and forecasts are provided for the period ...
(Date:9/16/2014)... , Sept. 16, 2014 The Pulmonary Fibrosis ... data from more than 1,100 patients and families suffering ... Drug Administration (FDA) for the Patient-Focused Drug Development Meeting ... a new FDA initiative to seek patient input in ... therapeutic treatments. "We applaud the FDA for ...
(Date:9/16/2014)...  This report analyzes the worldwide markets for Digital Radiography ... analytics for the US, Canada , ... Asia-Pacific , Middle East , ... Annual estimates and forecasts are provided for the period 2013 ... these markets. Market data and analytics are derived from primary ...
Breaking Medicine Technology:Global Animal Medication Industry 2Global Animal Medication Industry 3Global Animal Medication Industry 4Global Animal Medication Industry 5Global Animal Medication Industry 6Global Animal Medication Industry 7Global Animal Medication Industry 8Global Animal Medication Industry 9Global Animal Medication Industry 10Global Animal Medication Industry 11Global Animal Medication Industry 12Global Animal Medication Industry 13Global Animal Medication Industry 14Global Animal Medication Industry 15Global Animal Medication Industry 16Global Animal Medication Industry 17Global Animal Medication Industry 18Global Animal Medication Industry 19Global Animal Medication Industry 20Global Animal Medication Industry 21Global Animal Medication Industry 22Global Animal Medication Industry 23Global Animal Medication Industry 24Global Animal Medication Industry 25Global Animal Medication Industry 26PFF Submits Survey Data From More Than 1,100 Pulmonary Fibrosis Patients And Families To U.S. Food And Drug Administration For Upcoming Drug Development Meeting 2PFF Submits Survey Data From More Than 1,100 Pulmonary Fibrosis Patients And Families To U.S. Food And Drug Administration For Upcoming Drug Development Meeting 3PFF Submits Survey Data From More Than 1,100 Pulmonary Fibrosis Patients And Families To U.S. Food And Drug Administration For Upcoming Drug Development Meeting 4Global Digital Radiography Industry 2Global Digital Radiography Industry 3Global Digital Radiography Industry 4Global Digital Radiography Industry 5Global Digital Radiography Industry 6Global Digital Radiography Industry 7Global Digital Radiography Industry 8
... (NASDAQ: MASI ) today announced that in line ... Cost of Care by Taking Noninvasive Monitoring to New Sites ... (SpHb®) will further the company,s stated mission,  Masimo is introducing ... ransfusion R elated C ost R eduction ...
... JAZZ ) today announced that the company will host ... 2011 at 4:30 p.m. EST/9:30 p.m. GMT. During the call, ... quarter and full year 2011 financial results. The ... Investors section of the Jazz Pharmaceuticals, website at www.jazzpharmaceuticals.com ...
Cached Medicine Technology:Masimo Announces "Better Care" Program - A Hospital Risk-Share Program for Blood Transfusion Related Cost Reduction with SpHb®, and $30 SpHb Sensor Price 2Masimo Announces "Better Care" Program - A Hospital Risk-Share Program for Blood Transfusion Related Cost Reduction with SpHb®, and $30 SpHb Sensor Price 3Masimo Announces "Better Care" Program - A Hospital Risk-Share Program for Blood Transfusion Related Cost Reduction with SpHb®, and $30 SpHb Sensor Price 4Masimo Announces "Better Care" Program - A Hospital Risk-Share Program for Blood Transfusion Related Cost Reduction with SpHb®, and $30 SpHb Sensor Price 5Masimo Announces "Better Care" Program - A Hospital Risk-Share Program for Blood Transfusion Related Cost Reduction with SpHb®, and $30 SpHb Sensor Price 6Masimo Announces "Better Care" Program - A Hospital Risk-Share Program for Blood Transfusion Related Cost Reduction with SpHb®, and $30 SpHb Sensor Price 7
(Date:9/17/2014)... / MANILA, PHILIPPINES (PRWEB) September 17, 2014 ... Managed Operations and Business Process Outsourcing (BPO) services in ... the firm as the Senior Vice President – North ... , Cary Weltken is a 15 year veteran ... wealth of experience in helping companies, ranging in size ...
(Date:9/17/2014)... Health.Verticalize, a healthcare marketing company which ... insurance options in the 2014 open enrollment period, has ... forward Health Network will be using ... intentionally remained out of the spotlight for the last ... website to its present position with dozens of targeted ...
(Date:9/17/2014)... 1st-Dress.com, one of the most distinguished dress ... bridesmaid dresses recently. All the fresh items provided ... Furthermore, they are offered at deeply discounted rates at ... The firm is striving to provide a nice shopping ... never compromises on style, quality and customer service. Currently, ...
(Date:9/16/2014)... Top10BestSEOHosting.com has recently compared many ... companies for the webmasters that want to buy ... , The senior spokesman for Top10BestSEOHosting.com says, “We ... HostMonster are the excellent hosting companies for worldwide ... wide range of advanced features while still maintaining ...
(Date:9/16/2014)... (PRWEB) September 17, 2014 Marybeth Cale, owner ... ninety miles north of Manhattan in the small village of ... arm to the business. Cale, a mompreneur, has expanded the ... motivate and inspire people to maximize potential. Those services will ... as well as one-on-one life coaching for clients all over ...
Breaking Medicine News(10 mins):Health News:MicroSourcing Appoints New Senior Vice President of North America 2Health News:Health.Verticalize Rebrands as Health Network After Growing to 15 Million Users in Less Than One Year 2Health News:Health.Verticalize Rebrands as Health Network After Growing to 15 Million Users in Less Than One Year 3Health News:2014 Long Bridesmaid Dresses Available Online At 1st-Dress.com 2Health News:Top10BestSEOHosting.com: Arvixe Is One Of The Best SEO Hosting Suppliers 2Health News:Mompreneur Marybeth Cale of Cale Communications Announces Launch Of Life Coaching And Workshop Business 2
... Reinberg HealthDay Reporter , WEDNESDAY, Jan. 12 (HealthDay News) ... United States is expected to reach at least $158 billion -- ... the U.S. National Cancer Institute. The surge in cost will ... develop more cases of cancer in the near-term. And projected ...
... important step toward understanding human mating behavior by showing ... they interact with the opposite sex. This research, published ... GENETICS ( http://www.genetics.org ), shows that courtship behaviors ... thought. In addition, understanding why and how these ...
... preoperative Breast MRI detects otherwise occult cancer with a relatively ... of patients newly diagnosed with breast cancer, according to a ... of Roentgenology . The study was performed at the ... WA. The review initiated with 592 patients who ...
... Adding customer service representatives to a computerized radiology ... physician satisfaction and increased radiologist efficiency, an analysis ... in Cincinnati finds. Seven customer service representatives ... am 11:00 pm daily and are responsible ...
... , WEDNESDAY, Jan. 12 (HealthDay News) -- Just over ... estimates from the U.S. Centers for Disease Control and Prevention. ... current asthma trends, as outlined in a National Center for ... and Mortality: United States, 2005-2009." A study team led ...
... obesity-related respiratory difficulties are fairly common disorders that affect ... Jennum, Professor of Clinical Neurophysiology at the Center for ... Health Sciences. He is head of the Danish Centre ... all over the country. "Previous studies show ...
Cached Medicine News:Health News:Aging Population Could Send Cancer Costs Soaring 2Health News:Attention ladies and gentlemen: Courtship affects gene expression 2Health News:Customer representatives mean increased efficiency in radiology 2Health News:CDC Report Finds 8% of Americans Have Asthma 2Health News:Sleep-disordered breathing comes at a heavy cost 2
... Quantel Medical Inc., the first to ... for ophthalmology, is proud to announce their ... solid-state green laser solves the problem that ... offices and operating rooms. No larger than ...
... all Gilson disposable pipette tips, ... sterilized version. Each Sterilized TowerPack ... device-quality plastic to help protect ... guaranteed by the red sticker, ...
This large orifice 1000 ul tips is the large volume alternative to MBP's 200G tip. Pipet fragile cells, viscous samples and genomic DNA with ease....
... in plastic-wrapped racks of 96 tips, Sterilized ... to autoclave. Sterilized Diamond Tips are irradiated ... are delivered with a certificate of sterilization, ... Tips are certified free of detectable Rnase, ...
Medicine Products: