Navigation Links
Intercept Pharmaceuticals' FXR Agonist INT-747 Meets Primary Endpoint in a Phase II Clinical Trial in Type 2 Diabetic Patients with Nonalcoholic Fatty Liver Disease
Date:10/1/2009

NEW YORK, Oct. 1 /PRNewswire/ -- Intercept Pharmaceuticals, Inc., has announced that its first-in-class farnesoid X receptor (FXR) agonist INT-747 has met the primary endpoint of improved insulin sensitization in a 6 week double blind, placebo controlled trial in type 2 diabetic patients with nonalcoholic fatty liver disease (NAFLD).

By employing a euglycemic insulin clamp procedure, the study demonstrated that a single oral daily dose of INT-747 statistically significantly improved glucose disposal rate, consistent with improved hepatic and peripheral insulin sensitivity. Furthermore, patients treated with INT-747 demonstrated statistically significant weight loss and improved biochemical markers of liver function. The compound was well tolerated at the doses tested, with side effects similar to placebo.

Intercept's Chief Medical Officer, David Shapiro, MD, commented, "INT-747 therapy generated several clinically meaningful signals in this first proof of concept study, validating the mechanism of action of FXR activation that we and other groups have described preclinically." Dr. Shapiro is presenting the results of the trial on Friday, Oct. 2, in a plenary session at the European Association for the Study of Diabetes (EASD) annual meeting.

Insulin resistance is an important driver of liver fibrosis, the progressive scarring that can lead to cirrhosis. Based on INT-747's ability to improve insulin sensitivity and other important parameters of liver function in this patient population, Intercept is planning to initiate a Phase II trial in patients with nonalcoholic steatohepatitis (NASH) in 2010. There are an estimated 5 million or more NASH patients in the United States alone with no effective therapeutics currently available.

About Intercept Pharmaceuticals

Intercept is a clinical stage biopharmaceutical company focused on discovering and developing small molecule drugs for the treatment of chr
'/>"/>

SOURCE Intercept Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Merriman Curhan Ford Acted as Financial Advisor to TorreyPines Therapeutics, Inc. in the Completed Merger With Raptor Pharmaceuticals Corp.
2. Sanofi-aventis and Merrimack Pharmaceuticals Enter Into a Worldwide Collaboration and Licensing Agreement on MM-121, an Anti-ErbB3 Monoclonal Antibody
3. Fovea Pharmaceuticals to be Acquired by sanofi-aventis
4. Sagent Pharmaceuticals Launches Vinorelbine Injection, USP
5. Cadence Pharmaceuticals to Webcast October 7th Analyst Day
6. Raptor Pharmaceuticals Corp. and TorreyPines Complete Merger
7. Arena Pharmaceuticals Reports Positive, Highly Significant BLOSSOM Trial Results for Weight Management; NDA Submission on Track for December
8. Arena Pharmaceuticals to Host Conference Call and Webcast on Friday, September 18, 2009, to Discuss Results from the BLOSSOM Phase 3 Trial of Lorcaserin for Weight Management
9. Strativa Pharmaceuticals Development Partner, BioAlliance Pharma, Presents Phase III Study Results of Miconazole Lauriad(R) for the Treatment of Oropharyngeal Candidiasis
10. Keryx Biopharmaceuticals Phase 2 Data of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Renal Cell Cancer Selected for Oral Presentation at the Eighth International Kidney Cancer Symposium
11. In Vitro Study of Adamas Pharmaceuticals Triple Combination Antiviral Drug Therapy Shows Activity Against Drug-Resistant Influenza Viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... TAMPA, Fla. , Jan. 23, 2015  iMD Companies, Inc. ... plan to increase market share and grab a foothold in ... with influence, production capabilities and a presence in the sector, ... them facilitate the growth of hemp and medical marijuana, iMD ...
(Date:1/23/2015)... , Jan. 23, 2015  Mallinckrodt plc (NYSE: ... has approved a share repurchase program. The open-ended authorization ... of Mallinckrodt plc ordinary shares. "Funding ... top priorities as we continue to pursue a range ...
(Date:1/22/2015)... Colo. , Jan. 22, 2015  BiOptix is pleased ... as Vice President of Chemistry and Biochemistry. Scott joins ... Pharmaceuticals, AstraZeneca Pharmaceuticals, and Amgen throughout the course of ... development. "Scott is a nationally recognized thought ...
Breaking Medicine Technology:iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2
... Calif., March 2, 2011 Nile Therapeutics, Inc. (Nasdaq: ... development of novel therapeutics for heart failure patients, today ... a positive determination from the NASDAQ Listing Qualifications Panel ... Company,s request for an extension to remain listed on ...
... PARSIPPANY, N.J., March 2, 2011 Pacira Pharmaceuticals, ... specialty pharmaceutical company, today announced that positive results ... extended-release liposome injection) in patients with moderate hepatic ... Society for Clinical Pharmacology and Therapeutics (ASCPT) 112th ...
Cached Medicine Technology:Nile Therapeutics Receives Positive NASDAQ Panel Decision 2Nile Therapeutics Receives Positive NASDAQ Panel Decision 3Pacira Pharmaceuticals' EXPAREL™ Data to be Featured at 2011 ASCPT 112th Annual Meeting 2Pacira Pharmaceuticals' EXPAREL™ Data to be Featured at 2011 ASCPT 112th Annual Meeting 3
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the release ... for kids with cancer. The Chemo Duck App, available on iTunes ... enjoyable games to help children of all ages living with cancer ... keep kids entertained, educated and at ease while waiting for clinic ...
(Date:1/22/2015)... 23, 2015 Angelweddingdress is a famous wedding ... its customers to follow it on Facebook, Twitter, and Pinterest. ... Day gift. Angelweddingdress draws a lottery every week. , Moreover, ... Feb. 28, 2015. Click Angelweddingdress homepage for more ...
(Date:1/22/2015)... Florida (PRWEB) January 22, 2015 Juvent ... today at the 2015 PGA Merchandise Show to bestow ... and incredible female amateur golfer, Arlene McKitrick. The award ... female amateur golf tournament win. She won her first ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 For over 20 years, ... Oceanside and Vista area has treated just about every ... personal injury circumstances. And for those same twenty-plus years, the ... of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Yesterday, ... Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were honored ... leadership in advancing biotechnology, biomedical science, medical device ... Olsen each received the “2014 Life Sciences Champion” ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3
... Ortho Organizers, Inc., a,leading manufacturer of orthodontic products ... added a rectangular version to its,already popular Super ... The Super Elastic Nitanium Black Ti Archwire product ... orthodontic field,placing self-ligating brackets due its ultra smooth, ...
... is growing -- again. To,accommodate market growth, consumer ... space, with the occupancy of a new building ... ultimately enhance,the customer service experience for all clients, ... and maximize efficiency at critical,times., "The expansion ...
... Brennan, AstraZeneca,CEO, and senior management from AstraZeneca (LSE: ... in the biologics field, R&D and portfolio,progress plus ... transcripts are available now on http://www.cantos.com ., ... to do is register at, http://www.cantos.com ., ...
... CHESHIRE, Conn., Dec. 7 Alexion,Pharmaceuticals, Inc. (Nasdaq: ... hemoglobinuria (PNH), as well as to Soliris(R),(eculizumab), a treatment ... American Society of Hematology Meeting, December 8 - 11 ... in a poster session on red,cell regulation and disorders ...
... Healthy Families Montgomery Celebrates Ten Years of Service, ... can be,virtually eliminated when certain risk factors -- such ... -- are reduced,according to a new 10-year study released ... more than 600 families who participated in,FSA,s Healthy Families ...
... emerged only several thousand years ago, new research from ... ancient evidence of the disease has been found in ... of the new specimen of the human species, Homo ... who migrate northward from low, tropical latitudes produce less ...
Cached Medicine News:Health News:Ortho Organizers(R) Introduces Product Line Extension - Rectangular Super Elastic Nitanium(R) Black Ti(TM) Archwire 2Health News:Alexion Pharmaceuticals to Present Data on Soliris(R) (Eculizumab) and PNH at the 2007 American Society of Hematology (ASH) Annual Meeting 2Health News:County-Wide Home Visiting Program Found to Reduce Child Abuse and Neglect 2Health News:County-Wide Home Visiting Program Found to Reduce Child Abuse and Neglect 3Health News:Most ancient case of tuberculosis found in 500,000-year-old human; points to modern health issues 2
Standard reading test. 'It was the month of May'...
Standard reading test. "Clearing weather..."...
The PowerLab 4/25T is an integrated data recording unit featuring built-in amplifiers. With appropriate transducers and accessories the PowerLab 4/25T covers the broad experimental requirements in li...
Near PT test card/Tumbling E, tumbling hands 5 1/2" X 8"....
Medicine Products: