Navigation Links
Intercell Reports Positive Results From Its Phase II Pseudomonas Aeruginosa Investigational Vaccine Study for Certain Hospital-Acquired Infections
Date:10/25/2010

ity was similar in all vaccine groups. Functional opsonozation-uptake could be shown and correlated well with vaccine-induced IgG titers. Induction of functional antibodies is expected to be the major protective mechanism against Pseudomonas aeruginosa infections. Immune responses in intensive care patients appeared weaker compared to results from a preceding Phase I trial in healthy volunteers. This was not unexpected due to the reduced general health condition of patients enrolled.

Although this trial was not powered for efficacy the Clinical Endpoint Committee (CEC) confirmed infection rates and mortality were recorded within the secondary endpoints analysis.

A lower mortality rate was observed in all vaccine groups as compared to the control group.  The reduction in mortality rate was statistically significant (p = 0.0196) for the non-adjuvanted vaccine (21.7% day 28 mortality in the not-adjuvanted IC43 group compared to 40.0% day 28 mortality in the placebo group).

No significant difference in Pseudomonas aeruginosa infection rates between any of the groups was apparent. However, this is likely to be due to the relatively small sample size of the current Phase II study. Larger, sufficiently powered clinical studies would be required to validate and verify any vaccine effects on mortality and infection rates.

As another key objective, the current Phase II trial investigated the feasibility of performing pivotal efficacy studies in this difficult target population: Final data confirm the anticipated number of Pseudomonas aeruginosa infections. The observed attack rate of 6 - 14% is well within expectations as only study sites with estimated Pseudomonas aeruginosa invasive infection rates of 10 - 25% were selected for this trial. These results confirm the development strategy for Intercells's Pseudomonas aeruginosa vaccine and could allow a pivotal assessment o
'/>"/>

SOURCE Intercell AG
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Romark and Intercell Join Forces in Combining Therapies Against Hepatitis C
2. Intercell and Romark Join Forces in Combining Therapies Against Hepatitis C
3. Intercell AG Appoints Staph Leavenworth Bakali as Chief Business Officer
4. Intercell Acquires Antibody Technology Platform to Further Exploit Its Capabilities to Combat Infectious Diseases
5. Intercell AG Announces First Subject Enrolled in a Phase II Trial for the Further Development of Its Investigational Vaccine Enhancement Patch to Improve Pandemic Influenza Prevention in Collaboration With U.S. Department of Health and Human Services (HHS
6. Intercell Starts a Phase I Clinical Trial for a New Streptococcus pneumoniae Vaccine
7. Intercell AG Partners with Inclinix to Enroll 1800 Volunteers for Phase III Travelers Diarrhea Vaccine Study
8. USD 12.5 m Funding for the Development of Intercells Vaccine Patch System for Pandemic Influenza From U.S. Department of Health and Human Services (HHS)
9. Favourable Six Months Follow-Up Results From Intercells Phase II Therapeutic Hepatitis C Program
10. Intercell Announces Initiation of Further Phase II Clinical Trial of V710 an Investigational Vaccine to Prevent S. aureus Infection
11. Intercell AG to Acquire Iomai Corporation to Expand Late Stage Product Pipeline and Strengthen Leadership in Vaccine Innovation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... -- In a new, interactive guide, DICOM Grid ... electronic medical record (EMR) and image management systems. ... how seamless integration makes diagnostic studies accessible within ... http://photos.prnewswire.com/prnh/20140827/140443 "Just five years ... the patient record was near impossible. Fast-forward to ...
(Date:8/27/2014)... Columbia and MENLO PARK, Calif. ... Inc. , (OTCQB: DMPI), developer of advanced cancer ... at the 16th Annual Rodman & Renshaw Global Investment ... LLC. The presentation will take place Tuesday, September 9th at ... floor) at the New York Palace Hotel in ...
(Date:8/27/2014)... FAIRFAX, Va. , Aug. 27, 2014 ... in the legs due to buildup of fatty plaque ... expected in the aging patient population and in incidences ... Radiology offers its Lower Extremity Arterial RevascularizatioN ... Ariz. Endovascular specialists and interested residents and ...
Breaking Medicine Technology:DICOM Grid Launches Interactive Guide to Demonstrate Image-Enabling the EMR 2DelMar Pharmaceuticals To Present At The 16th Annual Rodman & Renshaw Global Investment Conference 2DelMar Pharmaceuticals To Present At The 16th Annual Rodman & Renshaw Global Investment Conference 3DelMar Pharmaceuticals To Present At The 16th Annual Rodman & Renshaw Global Investment Conference 4LEARN to Treat Peripheral Arterial Disease Patients 2LEARN to Treat Peripheral Arterial Disease Patients 3
... ROCKVILLE, Md., Oct. 26 MedAvante, Inc., the ... system (CNS) disorders, and Rexahn Pharmaceuticals, Inc. (NYSE ... pharmaceutical company developing and commercializing potential best in ... will use MedAvante ,s Remote Centralized Ratings™ in ...
... Healthy Advice ® Networks, the nation,s leading ... physicians, is pleased to announce they have been ... health information once again by the National Health ... institutions as the Mayo Clinic and the American ...
Cached Medicine Technology:Rexahn to Use MedAvante Centralized Ratings in MDD Phase 2b Study 2Rexahn to Use MedAvante Centralized Ratings in MDD Phase 2b Study 3Healthy Advice® Networks Wins 39 National Health Information Awards 2Healthy Advice® Networks Wins 39 National Health Information Awards 3
(Date:8/27/2014)... The New York Mobility Club (sponsored by ... about “ Sexuality & Intimacy ” for people with ... entertaining discussions are for mature audiences only. September 9 ... Mamaroneck, NY) and October 7 from 6-8 pm at ... The New York Mobility Club is a local community ...
(Date:8/27/2014)... Angeles, CA (PRWEB) August 27, 2014 ... to require a consumer to present personal information before ... changing the way that life insurance quotes are distributed ... , The term plans that an adult has ... provided by known U.S. companies. The system for quotation ...
(Date:8/27/2014)... Top 10 Best SEO Hosting, a well-known SEO Hosts Review ... iPage, Bluehost and GoDaddy are the most recommended suppliers for ... buy useful hosting (including VPS and cloud hosting). , ... has been serving hosting small business websites since 1998. With ... leader in the hosting industry for its affordable and easy ...
(Date:8/27/2014)... Recently, iFitDress.com, a professional company of ... designs of romantic bridal gowns . To top ... price (up to 66 percent off) when buying the ... line has been updated with these new items. All ... hopes that all clients can gain an enjoyable shopping ...
(Date:8/27/2014)... Skirt Sports , the innovative women’s running apparel brand ... Switzer, most noted for her brave running of the 1967 ... women’s running clothes that unites the history of women’s competitive ... , “It is such an honor to work ... is the original Skirt – she stood strong, pushing herself ...
Breaking Medicine News(10 mins):Health News:Bussani Mobility Sponsors New York Mobility Club Meetings September 9 & October 7 for People with Disabilities, Sexuality & Intimacy Discussed by Advocate Liz Treston 2Health News:Life Insurance Quotes for Term Policies Now Found at Insurer Website Online 2Health News:Well-known SEO Hosts Review Site Top10BestSEOHosting.com Recommends iPage, Bluehost and GoDaddy To Webmasters 2Health News:Promotion For Romantic Bridal Gowns Launched By Professional Company iFitDress.com 2Health News:Skirt Sports Launches Clothing Line with Legendary Runner Kathrine Switzer 2
... , , WARRENDALE, Pa., July ... to be showcased at the Premier healthcare alliance ... suppliers that are committed to improving patient outcomes through product innovation. ... one of only 24 products showcased at the event. , ...
... vitamin B deficiency , FRIDAY, July 17 (HealthDay ... surgery helps patients lose weight faster and avoid vitamin ... the "good" bacteria found in yogurt and in dietary ... of Medicine study included 44 patients who had Roux-en-Y ...
... Companies ... of dollars, says Reed Group President, Guidelines, Jon Seymour, MD. , ... Westminster, CO (Vocus) July 16, 2009 -- Companies whose ... dollars, says Reed Group President, Guidelines, Jon Seymour , MD. , , ...
... July 17 Dr. Gabriel DeCandido, a physician practicing internal medicine ... million to settle allegations that he defrauded the Medicare program, the ... In a complaint filed in the United States District Court ... Michael Flanery v. Dr. Gabriel DeCandido, et al ., the United ...
... , ELM GROVE, Wis., July 17 ... Percentile Rankings Within 4 Months is the second in ... a hospital process improvement firm. With federal funding at risk, ... helping avoid common mistakes made by hospitals when working on programs ...
... , SANTA MONICA, Calif., July 17 ... critical thinking, created the new website www.prescriptiondrugs.procon.org ... advertised directly to consumers?" , , ... published on whether direct to consumer (DTC) prescription drug ads ...
Cached Medicine News:Health News:MEDRAD Recognized by the Premier Healthcare Alliance for Commitment to Healthcare Quality Improvement and Innovation 2Health News:MEDRAD Recognized by the Premier Healthcare Alliance for Commitment to Healthcare Quality Improvement and Innovation 3Health News:MEDRAD Recognized by the Premier Healthcare Alliance for Commitment to Healthcare Quality Improvement and Innovation 4Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 2Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 3Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 4Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 5Health News:Tampa Bay Doctor Agrees to Pay United States $1.7 Million to Resolve Medicare Fraud Allegations 2Health News:Compirion Healthcare Sponsors Webinar on 7 Mistakes That Lower Patient Satisfaction Scores 2Health News:Compirion Healthcare Sponsors Webinar on 7 Mistakes That Lower Patient Satisfaction Scores 3Health News:Debate Over Advertising Prescription Drugs to Consumers Goes Online at New ProCon.org Website 2
... Esteem™ External Vacuum Therapy System restores sexual ... men. Non-invasive and low cost vacuum therapy, ... desirable outcome", makes it the ideal therapy ... Therapy System causes penile rigidity that can ...
Easy to Use manual vacuum system features a pumping mechanism that can be operated with one hand....
... D.O.R.C. Associate is an advanced ophthalmic ... and Venturi pump, allowing surgeons to ... Phaco or Vitrectomy procedures.,The key feature ... microprocessor-controlled vacuum system that measures in-line ...
... D.O.R.C. Harmony Total TTC® is a complete ... vitreoretinal surgery. Color coded function modes with ... compact design assures an easy to operate ... linear function footswitch provides the surgeon complete ...
Medicine Products: