Navigation Links
InterMune Reports Presentation of Triple Combination Study of ITMN-191 at European Association for the Study of the Liver (EASL)
Date:4/24/2009

otality of the viral kinetic data, the q12h and q8h regimens delivered very convincing results and appeared to perform very comparably in this 14-day study. The safety and tolerability profile of ITMN-191 in both the earlier monotherapy study and in the present triple combination study was also encouraging, as no issues of concern were observed. We look forward to the Phase 2b study to determine if the very promising profile of ITMN-191 observed will be confirmed."

InterMune noted that a Phase 2b triple combination trial of ITMN-191 is planned for initiation in the summer of 2009. A Phase 1 trial of ITMN-191 and polymerase inhibitor R7128 (INFORM-1 Study) is currently underway.

Steven Porter, M.D., Ph.D., Chief Medical Officer of InterMune, said, "The Phase 1b triple combination study was designed to inform the dose selection and study design of the ITMN-191 Phase 2 program. The Phase 2b program will study both q12h regimens (600mg and 900mg q12h) and a q8h regimen (300mg q8h) and both 12-week and 24-week treatment durations. We believe that the viral kinetic and safety results reported today provide evidence that ITMN-191 has the potential to deliver superior sustained virologic response (SVR) rates in patients chronically infected with the hepatitis C virus."

Viral Kinetic Performance

After 14 days of triple combination therapy, the median change in HCV RNA from baseline exceeded 5 logs in five of the six cohorts and was -5.4 log and -5.7 log in the best performing q12h and q8h cohorts, respectively. Considering all cohorts, HCV RNA was below the limit of quantification in nearly three-quarters (71%, or 32 of 45) of patients who received treatment with ITMN-191 after only 14 days of treatment. In all q12h and q8h cohorts, reductions in HCV RNA occurred rapidly and there was no evidence of viral rebound during ITMN-191 treatment.

Safety and Tolerability Profile


'/>"/>
SOURCE InterMune, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. InterMune Announces Approval of Clinical Trial Authorization for Phase 1b Trial of ITMN-191
2. InterMune Announces Start of Phase 1b Trial of ITMN-191
3. InterMune Announces Top-Line Results of Phase 1b Trial of ITMN-191 (R7227) and Provides Program Update
4. InterMune Provides Additional Information on ITMN-191 (R7227) MAD Study Results
5. InterMune Announces Progress on Pirfenidone in IPF
6. InterMune Announces Receipt of Fast Track Designation for Pirfenidone From FDA
7. InterMune Announces Start of 14-Day Triple Combination Study of ITMN-191 in Patients With Chronic Hepatitis C
8. Roche, InterMune and Pharmasset Announce Initiation of INFORM-1, the First Dual-Combination Clinical Trial with Oral Antivirals in Hepatitis C
9. InterMune to Report Top-Line Results of Triple Combination Study of ITMN-191 in January 2009
10. InterMune to Conduct Conference Call and Webcast to Discuss Results of Triple Combination Study of ITMN-191
11. InterMune to Announce Results of Phase 3 CAPACITY Program of Pirfenidone in IPF Tomorrow, February 3
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 21, 2014  Publicis Groupe customer engagement agency ... Partner and Healthcare Industry Group Leader, has been featured ... the most inspiring people in the life-sciences industry. Those ... and development, marketing, technology, creativity, strategy and medicine. ... a partner in its leading Rosetta Consulting practice. In ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... of COPD,  physicians in Brazil ... to follow clinical guidelines and commonly prescribe long-acting ... regimens, although they do so within current severe ... combinations (FDCs) that are expected to launch in ...
(Date:8/21/2014)... 2014 /PRNewswire-iReach/ -- ScriptPro has been certified by ... Common Security Framework (CSF). According to Russ ... "We appreciate this rigorous, top-to-bottom audit. Security-minded customers ... certification signifies. Our business partners need to know ... CERTIFICATION PROCESS: ScriptPro,s internal security processes and controls ...
Breaking Medicine Technology:Shannon Hartley Shines in PharmaVOICE 100 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3ScriptPro Achieves HITRUST Certification 2
... , , INDIANAPOLIS, Nov. 16 AMD ... laser technology, today announced the addition of Bart Waclawik ... Mr. Waclawik will be responsible for daily global operations, ... the company. Furthermore, he will lead the engineering effort ...
... Nov. 16 Despite the recession, overall growth ... 15 percent in the past two years, according to a ... Solutions. Retail clinic market growth, however, will likely slow to ... 30 percent from 2013-2014, according to the report. , ...
Cached Medicine Technology:AMD LASERS Announces the Addition of Bart Waclawik, New Chief Operating Officer 2Health Care Retail Clinics Continue Gradual Expansion Through 2012: Deloitte Center for Health Solutions Report 2Health Care Retail Clinics Continue Gradual Expansion Through 2012: Deloitte Center for Health Solutions Report 3Health Care Retail Clinics Continue Gradual Expansion Through 2012: Deloitte Center for Health Solutions Report 4
(Date:8/21/2014)... Recently, Top10BestSEOHosting.com has compared many professional SEO ... one of the most reliable suppliers for webmasters who ... been a boom in websites in recent years, and ... the number of web hosting companies that offer a ... HostMonster has been providing hosting solutions to thousands of ...
(Date:8/21/2014)... Recently, Skmen.com, a distinguished garment supplier, has updated ... girls’ casual dresses . From today until August 31, all ... off) when they are shopping at the company’s online store. ... according to the newest quality standards; they are guaranteed to ... dresses, worldwide ladies can also access the other cheap items ...
(Date:8/21/2014)... Lake City, Utah (PRWEB) August 21, 2014 ... ) is pleased to announce the addition of ... over 30 years of healthcare management experience, Gillespie ... His experience includes multiple executive management positions with ... Most recently Kerry served as President of Triad ...
(Date:8/21/2014)... (PRWEB) August 22, 2014 Top10BestSEOHosting.com ... and announces that iPage ( http://www.top10bestseohosting.com/go/iPage/ ) is ... in 2014. , The manager of Top10BestSEOHosting.com ... cheap hosting supplier. Actually, these companies have outperformed ... and customer support. People can get the best ...
(Date:8/21/2014)... Fayetteville, Georgia (PRWEB) August 21, 2014 ... amenities and the atmosphere that comes along with it. ... Fayetteville makes sure that such amenities are available. ... lifestyle community in Fayetteville, Georgia and Community Association Management, ... structure from American Parks Company to provide an additional ...
Breaking Medicine News(10 mins):Health News:Best SEO Hosting Suppliers in the Global Market Recommended by Top10BestSEOHosting.com 2Health News:Charming Girls’ Casual Dresses Now Released by Distinguished Garment Company Skmen.com 2Health News:Kerry Gillespie Appointed as Chief Executive Officer of AVEC Health Solutions 2Health News:iPage Reviews Unveiled Online At Top10BestSEOHosting.com 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3
... , MONDAY, Jan. 3 (HealthDay News) People ... of becoming obese, new study findings show. Researchers at ... from two large U.S. alcoholism surveys conducted in 1991-1992 and ... women with a family history of alcoholism were 49 percent ...
... the U.S has seen a sharp increase in the number ... weeks, gestation. This is approximately 400,000 children each year, comprising ... are treated the same as full-term infants since they are ... that this can be detrimental to a late-preterm infant,s health ...
... Chronic Total Occlusion Summit and Left Main Coronary ... technologies, research findings and new developments in therapeutic ... in chronic total coronary occlusions and left main ... include:, When and why to open a ...
... chemical group to it at a specific site, a protein ... international research team led by scientists at The University of ... of Nature Cell Biology . In addition to ... same deactivation of the enzyme called EZH2 is necessary for ...
... 2011 For the first time, universal standards to ... medication labels to reflect how patients read and understand ... These labels can vary significantly from pharmacy to pharmacy, ... for the safe use of medications. The new standards, ...
... Philadelphia, PA, January 3, 2011 Postoperative adhesions are ... been used in the hopes of preventing these adhesions ... article in the December 2010 issue of the ... American Association of Pediatric Ophthalmology and Strabismus, a team ...
Cached Medicine News:Health News:Family History of Alcoholism May Raise Obesity Risk 2Health News:Care of late-preterm preemies may be insufficient 2Health News:Care of late-preterm preemies may be insufficient 3Health News:Protein wields phosphate group to inhibit cancer metastasis 2Health News:Universal standards proposed for prescription container labels to help reduce medication misuse 2Health News:Universal standards proposed for prescription container labels to help reduce medication misuse 3Health News:Use of amniotic membrane may cause complications in strabismus surgery 2
... disposable pipette tips, TowerPacks are ... Each Sterilized TowerPack is individually ... to help protect tips from ... the red sticker, which indicates ...
... designed to optimize the accuracy and precision ... products is widely recognized by customers throughout ... extended over the years and now covers ... tips including filter tips, certified pure tips, ...
... Finntip Filters are ideal for ... or for any work where ... are designed for pipetting DNA/RNA ... and other. For applications requiring ...
... are ideal for PCR ... or for any work ... occur. They are designed ... infectious materials, labelled samples, ...
Medicine Products: