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InterMune Reports Preliminary Fourth Quarter 2011 Esbriet® (pirfenidone) Revenue and Other Recent Business Highlights
Date:1/5/2012

Austria.  The net ex-factory price of Esbriet in Denmark is more than 35,000 euro, or just over $47,000 per patient, per year.  

InterMune currently is expanding its commercial infrastructure to support launches in the mid-sized EU countries.  The company currently expects to have a total headcount in the range of approximately 160 to 190 in its EU infrastructure by the end of the third quarter of 2012, assuming that country launches occur as planned.


New Efficacy Data of Esbriet in IPF: RECAP

RECAP is an ongoing open-label extension study, looking at the long-term administration of Esbriet in patients who completed the Phase 3 CAPACITY program.

Long-term safety results from RECAP were presented at the Annual Congress of the European Respiratory Society (ERS) in September 2011.  These results demonstrated that long-term treatment with Esbriet was safe and generally well-tolerated, with a long-term safety profile similar to that observed in CAPACITY.

New analyses of change in FVC and Survival in patients who received placebo in CAPACITY and were newly treated with Esbriet in RECAP have now been conducted.  These new efficacy analyses show that the patients with mild-to-moderate IPF newly treated with Esbriet in RECAP for 60 weeks, have similar FVC and survival outcomes when compared to those treated with Esbriet in CAPACITY for the same duration.

The analyses specifically examined the proportion of patients at Week 60 who experienced an FVC decline of 10% or greater, an outcome that is highly clinically relevant and predictive of mortality.  Patients treated with Esbriet in RECAP had outcomes that were similar to those treated with Esbriet in CAPACITY, and the proportion of patients experiencing FVC decrements of 10% or greater was approximately 40% lower than in the CAPACITY placebo group.  Overall survival of patients treated with Esbriet in RECAP was similar to that in
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SOURCE InterMune, Inc.
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