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InterMune Provides Additional Information on ITMN-191 (R7227) MAD Study Results
Date:4/2/2008

BRISBANE, Calif., April 2, 2008 /PRNewswire-FirstCall/ -- Following its press release and conference call of April 1, 2008, InterMune, Inc. (Nasdaq: ITMN) today provided additional information on its Phase 1b multiple-ascending-dose (MAD) study of ITMN-191 to facilitate comparison with previously published data describing other HCV protease inhibitors. The additional information pertains to the Day 14 median reductions in HCV RNA in this study (see table below).

Mean Maximum

Reduction Day 14 Median

Total HCV RNA HCV RNA Reduction

Cohort Dose Daily Log10 IU/mL Log10 IU/mL

Dose (mg) (%*) (%*)

1 100 mg q12h 200 1.6 0.7

(97.49%) (80.05%)

2 100 mg q8h 300 2.6 1.7

(99.75%) (98.01%)

3 200 mg q12h 400 3.4 3.1

(99.96%) (99.92%)

4 200 mg q8h 600 3.9 3.8

(99.99%) (99.98%)

*Calculated from log10 reductions shown in table.

One final cohort consisting of treatment-experienced patients dosed at 300mg every 12 hours will begin dosing next week.

About InterMune

InterMune is a biotechnology company focused on the research, development and commercialization of innovative therapies in pulmonology
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SOURCE InterMune, Inc.
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