Navigation Links
InterMune Announces Top-Line Results of Phase 1b Trial of ITMN-191 (R7227) and Provides Program Update
Date:4/1/2008

ted by Roche.

Regarding formulation, InterMune reported that Roche has completed development of the tablet formulation of ITMN-191 that will be used in the Phase 2 program. Given the relatively low total daily dose of ITMN-191 required to show substantial antiviral activity, Roche has begun work on a modified-release formulation of ITMN-191 with the goal of optimizing the delivery of ITMN-191, potentially to a once per day administration.

Phase 1b (MAD) Trial Design

The ongoing Phase 1b placebo-controlled study is designed to assess the effect of multiple doses of ITMN-191 given as monotherapy on viral kinetics, viral resistance, pharmacokinetics, safety and tolerability. A principal goal of the MAD study is to help choose the range of doses of ITMN-191 that when administered in combination with Pegasys(R) (pegylated interferon alfa-2a) and Copegus(R) (ribavirin) would likely offer the optimal protease inhibitor-based triple combination regimen in terms of efficacy, safety and tolerability. The Phase 1b study also will inform the design of future combination studies using small molecule HCV compounds of different mechanisms of action.

In the Phase 1b study, four cohorts of treatment-nave patients received ITMN-191 in a gelatin capsule every 12 hours or every 8 hours with food for a period of 14 days. In addition, a single cohort of treatment-experienced chronic hepatitis C patients infected with HCV genotype 1 will begin dosing next week at the 300mg every 12 hour dose level.

Conference Call and Webcast Details

InterMune will host a conference call today at 8:30 a.m. EDT to discuss the preliminary Phase 1b clinical trial results of ITMN-191 and the Program Update. Interested investors and others may participate in the conference call by dialing 888-799-0528 (U.S.) or 706-634-0154 (international), conference ID #41908166. A replay of the webcast and teleconference will be available approximately three hours after the call. '/>"/>

SOURCE InterMune, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. InterMune Announces Start of Phase 1b Trial of ITMN-191
2. InterMune Announces Approval of Clinical Trial Authorization for Phase 1b Trial of ITMN-191
3. Bionovo Announces Publication of the Paper Detailing the Mechanism of Action of Its Cancer Drug BZL101
4. Kingfisher Announces FDA 510(k) Clearance of Breakthrough KFH Energy for Chronic Pain Sufferers
5. Genaera Corporation Announces MSI-1436 Data Presented at Society of Neuroscience Meeting
6. Keryx Biopharmaceuticals Announces Termination of SUN-MACRO Phase 4 Trial
7. Trubion Initiates Phase 1/2 Study of TRU-016 in CLL, Announces Next-Generation Product Candidate for RA and Provides Product Pipeline Update
8. Cystic Fibrosis Foundation Announces Positive Early Results for Phase 2 Clinical Trial of VX-770 - an Oral Compound to Treat CF
9. Poniard Pharmaceuticals Announces Commercial Manufacturing Agreement With W. C. Heraeus GmbH for Picoplatin
10. Nventa Announces Positive Interim Immunological Data From HspE7 Phase 1 Cervical Dysplasia Trial
11. Anacor Pharmaceuticals Announces Positive Results from Phase 2a Clinical Trial of AN2728 in Psoriasis Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... WASHINGTON , Sept. 30, 2014  The ... nurse managers to call them at 866-714-6466 if ... admitting Medicare patients, who should have been sent ... The reward potential can be substantial, as the ... Photo - http://photos.prnewswire.com/prnh/20140929/149016 ...
(Date:9/30/2014)... Summary This report presents the ... regarding their Information & Communications Technology (ICT) investment ... allocate their ICT budgets across the core areas ... communications, and consulting. Key Findings ... that X% of respondents anticipate an increase in ...
(Date:9/30/2014)... 2014  eHealth, electronic access of medical records, ... this information, has become a major industry. According ... not translated into user-friendly, effective products. ... http://photos.prnewswire.com/prnh/20140929/149123 For this reason, ... MWD® Health Manager iEHR, a multilingual web-based application ...
Breaking Medicine Technology:Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 2Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 3Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 4ICT investment trends in pharmaceuticals - Enterprise ICT spending patterns through to the end of 2015 2ICT investment trends in pharmaceuticals - Enterprise ICT spending patterns through to the end of 2015 3MWD Challenges the Big eHealth Players With New Software for Your Smartphone 2
... Council on Exercise (ACE), America,s leading authority on fitness ... organization in the world, today announced the launch of ... in America.  As an extension of the organization,s vision ... engage in physical activity and inspire them to make ...
... Hologic, Inc. (Hologic or the Company) (Nasdaq: ... premium diagnostics products, medical imaging systems and surgical products dedicated ... products that are the future of women,s imaging at the ... McCormick Place in Chicago, November 28 through December 2, 2010. ...
Cached Medicine Technology:American Council on Exercise (ACE) Announces Nationwide Effort to Eliminate Obesity in America 2American Council on Exercise (ACE) Announces Nationwide Effort to Eliminate Obesity in America 3Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 2Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 3Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 4Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 5Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 6Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 7Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 8Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 9
(Date:9/30/2014)... Healthpointe is proud to announce that Dr. ... ankle reconstruction surgeries to assist patients with severe orthopedic ... in the diagnosis and treatment of sports medicine, and ... trained to perform advanced Foot and Ankle Reconstruction to ... also fluent in Spanish. , Reconstructive surgical procedures for ...
(Date:9/30/2014)... September 30, 2014 Catalent Pharma ... advanced delivery technologies and development solutions for drugs, ... full agenda for the 25th Annual CPhI Worldwide ... October 6th to 9th. , Catalent is showcasing ... expansions during the show, including its facilities in ...
(Date:9/30/2014)... CA (PRWEB) September 30, 2014 ... the grand opening of its newest practice, located at ... offers digital x-rays, general dentistry services , and ... surgery. In addition to providing affordable and convenient dental ... emergency dental appointments . Call Coast Dental at ...
(Date:9/30/2014)... CT (PRWEB) September 30, 2014 With accolades ... slot in Lash Masters II, Hilaree Brand of My Brand ... of the craft and, more importantly, the ability to teach. ... by solid credentials and a great reputation. , With a ... licensed as a Master of Aesthetics and as an Instructor. ...
(Date:9/30/2014)... (L-T4), long the standard of care for treating ... individuals do not regain optimal health on L-T4 ... to explain these differences. An expert task force ... replacement reviewed the latest studies on L-T4 therapy ... change to the current standard of care is ...
Breaking Medicine News(10 mins):Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 2Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 3Health News:Catalent Showcases Advanced Technologies and Supply Capabilities at CPhI Worldwide Conference and Exhibition 2Health News:Catalent Showcases Advanced Technologies and Supply Capabilities at CPhI Worldwide Conference and Exhibition 3Health News:Coast Dental Clovis Celebrates Grand Opening 2Health News:Coast Dental Clovis Celebrates Grand Opening 3Health News:My Brand Lashes and Lash Affair By J. Paris Merge to Offer Premium Lash and Brow Products and Certifications 2Health News:My Brand Lashes and Lash Affair By J. Paris Merge to Offer Premium Lash and Brow Products and Certifications 3Health News:New hypothyroidism treatment guidelines from American Thyroid Association 2
... reductions in physician reimbursements for outpatient chemotherapy related drugs ... 2003 would have a detrimental effect on patients requiring ... major changes in travel distance and patient wait times ... to a study in the July 9 issue of ...
... to Lower Health Care Costs, ... Economy, PITTSBURGH, July 8 The chief executives ... at the first,Pennsylvania Insurance Department public hearing about the ... good for customers, health care,providers, and the communities the ...
... Modernization Act yet to show drop-off in access predicted ... Chemotherapy patients have not lost access to care despite ... in recent years, a new report finds. , Critics ... 2003 would make treatment more difficult, but investigators from ...
... shows , , TUESDAY, July 8 (HealthDay News) -- An ... not bestow any survival benefits on the patient beyond ... taking androgen deprivation therapy, which shuts off male hormones ... lower prostate cancer-specific survival rate. , "This ...
... from recent advances in treatment, survival, study finds , , ... U.S. declines in deaths from the four most common ... primarily benefiting better educated Americans, new research from the ... malignancies did drop significantly from 1993 to 2001, most ...
... Facing a blizzard of health-related,information, consumers and ... help sort good from bad and keep ... a market leader in,enterprise search, recently published ... are using new search technologies to better,serve ...
Cached Medicine News:Health News:Medicare Modernization Act not associated with major changes in access to chemotherapy 2Health News:Medicare Modernization Act not associated with major changes in access to chemotherapy 3Health News:Highmark and Independence Blue Cross CEOs Say Combination of Highmark and Independence Blue Cross will Provide $1 Billion in New Resources Over Six Years 2Health News:Cancer Care Unaffected by Doctor Reimbursement Changes 2Health News:Hormone Therapy Shows Little Benefit Against Prostate Cancer 2Health News:Hormone Therapy Shows Little Benefit Against Prostate Cancer 3Health News:College-Educated Fare Better When Cancer Strikes 2Health News:College-Educated Fare Better When Cancer Strikes 3Health News:Vivisimo Case Studies Detail Innovative Enterprise Search Applications by Medical Libraries, Women's Health Site 2Health News:Vivisimo Case Studies Detail Innovative Enterprise Search Applications by Medical Libraries, Women's Health Site 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: