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InterMune Announces Top-Line Results of Phase 1b Trial of ITMN-191 (R7227) and Provides Program Update
Date:4/1/2008

- Rapid and significant reductions in HCV RNA observed; well tolerated in

all dose cohorts - - Significant progress made in clinical, preclinical and formulation --

- Conference call and webcast today at 8:30 a.m. EDT --

BRISBANE, Calif., April 1, 2008 /PRNewswire-FirstCall/ -- InterMune, Inc. (Nasdaq: ITMN) today provided an overall program update and reported the top-line results from the four dose cohorts of treatment-naive patients in its ongoing Phase 1b clinical trial of ITMN-191, designated R7227 at Roche (SWX: ROG). ITMN-191 was administered as monotherapy in patients with chronic hepatitis C virus (HCV) genotype 1 infection. InterMune reported that treatment with ITMN-191 resulted in rapid and significant reductions in HCV RNA (see table below).

Total Daily Mean Maximum Reduction

Cohort Dose Dose (mg) HCV RNA Log10 IU/mL (range)

1 100 mg q12h 200 1.6 (0.9-2.2)

2 100 mg q8h 300 2.6 (1.7-3.6)

3 200 mg q12h 400 3.4 (2.4-4.4)

4 200 mg q8h 600 3.9 (3.0-5.0)

One final cohort consisting of treatment-experienced patients dosed at 300mg every 12 hours will begin dosing next week.

InterMune additionally reported that, based on a preliminary review of the available and still blinded clinical data from the four completed cohorts of the Phase 1b study, ITMN-191 was safe and well-tolerated. No serious adverse events were reported and no subject discontinued the study due to an adverse event. Adverse events were generally mild and transient in nature.

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SOURCE InterMune, Inc.
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