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Intellect Neurosciences Announces Its New CONJUMAB-A Platform Technology for Novel Treatments of Alzheimer's Disease and Other Proteinopathies
Date:10/26/2011

NEW YORK, Oct. 26, 2011 /PRNewswire/ -- Intellect Neurosciences, Inc. (OTCBB: ILNS), a biopharmaceutical company engaged in the discovery and development of disease-modifying therapeutic agents for the treatment of Alzheimer's and other neurological diseases announces today the commencement of the initial development of its new CONJUMAB-A platform technology for a novel class of therapeutics for treatment of Alzheimer's disease and other proteinopathies based on antibody-drug conjugates (ADCs).  Dr. Daniel G. Chain, the Company's Chairman and CEO and inventor of the CONJUMAB-A technology, will provide a brief description of the CONJUMAB-A technology during his presentation at BioInvestor Forum 2011 and in a video interview at the World ADC Summit, both taking place in San Francisco this week.  

The new ADC- based technology has the potential to improve on current methods of passive immunotherapy by increasing clearance of amyloid proteins while delivering potent cytoprotective molecules to sites of damage in the brain and other organs.  CONJUMAB-A is designed to reduce inflammation caused by amyloidosis while avoiding vasogenic edema, a side effect of plaque dissolution that occurs in some patients.   The company's lead CONJUMAB-A candidate is IN-N01-OX2, a non-activating, stabilized IgG4 humanized antibody specific for beta amyloid protein conjugated to melatonin, which is a naturally occurring molecule with potent anti-oxidant and anti-fibrillogenic properties.  

"We believe this exciting new approach may herald a new generation of promising drug candidates for the treatment of currently untreatable life-threatening diseases.  CONJUMAB-A capitalizes on the tremendous advances already made in the area of ADCs for cancer which have generated a plethora of advanced enabling drug conjugation technologies and also uses independent approaches," said Daniel Chain, Ph.D., Chairman and CEO of Intellect Neurosciences and invent
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