Navigation Links
Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)
Date:3/3/2009

ectly with those previously reported by Professor Blas Frangione and his colleagues from New York University more than ten years ago regarding a direct physical interaction between the beta amyloid protein and melatonin, a close structural homolog of OXIGON(TM). The interaction was shown to involve four specific amino acids, which now are known to comprise the high affinity copper binding site in the beta amyloid protein. Professor Hong's findings provide the missing link to explain the biochemical significance of these earlier findings, from which we gain additional insight into the mechanism of action of our drug candidate. OXIGON(TM) is considerably more potent than melatonin in blocking beta-amyloid neurotoxicity and offers several other pharmacological advantages."

"Neurotoxicity observed in AD is believed to be related to the toxicity from reactive oxygen species produced in the brain by beta-amyloid protein bound primarily to copper ions," commented Professor Kelvin Davies Chairman of the Company's Scientific Advisory Board. Dr Davies is the James E. Birren Chair in Gerontology and is Professor of Molecular & Computational Biology at the University of Southern California. Professor Davies added: "Moreover, the so-called 'redox activity' of the bound metal ion can lead to the formation of soluble neurotoxic oligomers as well as fibrillar forms of the protein, which eventually deposit as plaques in the brains of AD patients. This important new finding that the OXIGON(TM) molecule can bind metal ions such as copper is highly suggestive of a mode of action in common with other compounds, referred to as metal protein attenuating compounds, which have begun to show promising proof of concept in human clinical trials." Professor Davies concluded: "We believe that OXIGON(TM), which appears to be well tolerated in humans and enters the brain, is an especially promising drug candidate with broad therapeutic potent
'/>"/>

SOURCE Intellect Neurosciences, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. New Study Confirms That the Supports Intensity Scale Assessment is Effective in Measuring the Support Needs of People With Intellectual Disability and Making Funding Decisions
2. Cerenis Therapeutics In-Licenses Intellectual Property for New Treatment of Aortic Valve Stenosis
3. Quark Pharmaceuticals Announces First RNAi Drug Candidate Having a Novel, Proprietary Structure Covered by Quark Intellectual Property
4. Intellect Neurosciences, Inc. and Medical Research Council Technology (U.K.) Reach Important Milestone in Generating an Alzheimers Therapeutic Antibody
5. Intellect Neurosciences, Inc. and CHDI, Inc. Enter Into Compound Testing Agreement to Evaluate OXIGON(TM) as a Potential Treatment for Huntington Disease
6. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
7. Nektar Announces Positive Results from Phase 2 Study of Oral NKTR-118 in Patients with Opioid-Induced Constipation (OIC)
8. Hana Biosciences Announces Successful Planned Independent Safety Analysis Supports Ability to Complete Pivotal rALLy Clinical Trial of Marqibo, Its Lead Novel Anti-Cancer Compound
9. TissueGene Announces Regulatory Allowance to Initiate Phase IIa Study of TG-C in South Korea for Osteoarthritis of the Knee
10. Pharmaxis Announces New Drug Application Submission for Aridol(TM)
11. Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... May 6, 2015 Alexza Pharmaceuticals, Inc. (Nasdaq: ... quarter ended March 31, 2015.  The net loss and ... $0.4 million and $13.0 million, respectively, compared to $10.7 ... 2014, respectively.  At March 31, 2015, Alexza had consolidated ... $23.9 million. "We continue to focus on ...
(Date:5/6/2015)... , May 6, 2015 /CNW/ - Celebrities, bloggers and influencers across ... media to spread the important message that melanoma prevention begins ... Maria Sharapova , Hilary Duff , and parenting ... reached out to their networks on Monday to share this ... watch The David Cornfield Melanoma Fund ...
(Date:5/6/2015)... DUBLIN , May 06, 2015 Research ... announced the addition of the "Cannulas Market ... Femoral, Injector, Infusion, Venous, Microcannula), Material (Plastic, Metal) ... Global Forecast to 2020" report to their ... expected to grow at a CAGR of 5.6% ...
Breaking Medicine Technology:Alexza Reports 2015 First Quarter Financial Results 2Alexza Reports 2015 First Quarter Financial Results 3Alexza Reports 2015 First Quarter Financial Results 4Alexza Reports 2015 First Quarter Financial Results 5Alexza Reports 2015 First Quarter Financial Results 6Alexza Reports 2015 First Quarter Financial Results 7Alexza Reports 2015 First Quarter Financial Results 8Alexza Reports 2015 First Quarter Financial Results 9Alexza Reports 2015 First Quarter Financial Results 10Celebrities Tweet Their Support of Melanoma Awareness Month and #newfamilyrule 2Global Cannulas Market 2015 - Forecasts to 2020 with Medtronic, Edward Lifesciences, Terumo, Sorin & Maquet Holding B.V. & Co. Dominating 2Global Cannulas Market 2015 - Forecasts to 2020 with Medtronic, Edward Lifesciences, Terumo, Sorin & Maquet Holding B.V. & Co. Dominating 3
... TAXUS(R) Element(TM) Stent now available in select markets ... (NYSE: BSX ) today announced the ... Coronary Stent System in select markets worldwide. ... chromium alloy engineered specifically for coronary stent applications ...
... Pa., May 18 MEDRAD Interventional(TM)/Possis(R) today announced ... the Paccocath(R) Technology closer to market as an ... the United States and Europe who suffer from ... selection of physician investigators for U.S. clinical trials ...
Cached Medicine Technology:Boston Scientific Launches Third-Generation Platinum Chromium Drug-Eluting Stent 2Boston Scientific Launches Third-Generation Platinum Chromium Drug-Eluting Stent 3Boston Scientific Launches Third-Generation Platinum Chromium Drug-Eluting Stent 4Boston Scientific Launches Third-Generation Platinum Chromium Drug-Eluting Stent 5Unique Cardiovascular Treatment Readied for Global Market: Proprietary Paccocath(R) Technology is the Only Drug Eluting Balloon with Clinical Data 2Unique Cardiovascular Treatment Readied for Global Market: Proprietary Paccocath(R) Technology is the Only Drug Eluting Balloon with Clinical Data 3Unique Cardiovascular Treatment Readied for Global Market: Proprietary Paccocath(R) Technology is the Only Drug Eluting Balloon with Clinical Data 4Unique Cardiovascular Treatment Readied for Global Market: Proprietary Paccocath(R) Technology is the Only Drug Eluting Balloon with Clinical Data 5
(Date:5/6/2015)... FL (PRWEB) May 06, 2015 Qushanna Doby ... outside a nearby drug treatment center in Florida while under ... on May 4th. New surveillance tapes released by CBS4’s Peter ... without her baby. Doby’s child is around one year old. ... crying and shivering outside was not named. The residents polled ...
(Date:5/6/2015)... MD (PRWEB) May 06, 2015 The Canton ... Baltimore Ravens for the 6th annual charity softball game. ... at M & T Bank Stadium. Past years guests include ... others. Tickets are still on sale if you ... advocating for local non-profit organizations, such as SOAR Baltimore ...
(Date:5/6/2015)... 2015 TMG Health, the leading national ... Advantage, Medicare Part D and Managed Medicaid markets, was ... Team category at the BCI North America Awards, a ... the outstanding contribution of business continuity professionals and organizations ... including the USA and Canada. The North America Awards ...
(Date:5/6/2015)... Angeles (PRWEB) May 06, 2015 ... the #1 ranked international water, sanitation and hygiene nonprofit ... for communities across the world and it brings our ... Carnett, CEO of Marketing Maven. “The ongoing relationship between ... opportunities available for people to learn about and support ...
(Date:5/6/2015)... May 06, 2015 Vancouver Chiropractic ... shared their new blog containing the Canadian Physical ... the Canadian Society for Exercise Physiology (CSEP). Since ... activity, health and fitness research and personal training ... exercise are highly beneficial and a rich resource ...
Breaking Medicine News(10 mins):Health News:Flakka Induced Mother Abandons Baby, found by Florida Drug Treatment Center; New Video Released 2Health News:The Canton Group Sponsors Ravens Charity Softball Event 2Health News:The Canton Group Sponsors Ravens Charity Softball Event 3Health News:TMG Health Recognized by the Business Continuity Institute 2Health News:TMG Health Recognized by the Business Continuity Institute 3Health News:Marketing Maven Expands Partnership with the #1 Ranked International Water, Sanitation and Hygiene Nonprofit 2Health News:Marketing Maven Expands Partnership with the #1 Ranked International Water, Sanitation and Hygiene Nonprofit 3Health News:Vancouver Chiropractor Shares Canadian Physical Activity and Sedentary Behavior Guidelines by CSEP in New Blog 2
... of humour may help their babies fight skin allergies, ... issue of New Scientist. ,Japanese researcher Hajime Kimata ... a baby with a common allergy, mild atopic eczema. ... Chaplin movie or boring footage about weather, and their ...
... workers offers an overlooked but inexpensive way of ramping ... published by The Lancet on Thursday. It identifies ... skills than nurses but fewer than doctors -- that ... dozen sub-Saharan countries. ,NPCs are typically nurse ...
... time and again men have been dubbed as being preoccupied ... found that both men and women change their gender roles ... ,The University of Florida study demonstrates that men are under ... of different partners, and women are regarded as porters of ...
... fetuses from a maternity home in Haryana today. ... complaints from locals. , ,The police have registered a ... the clinic who is absconding. , ,"We sealed nursing ... was not available and now a search has started. Cases under ...
... Health Regulations (IHR) will enter into force on Friday. ... of rules and procedures, which envisages making the world ... ,The revised regulations were agreed by the ... step forward in international public health security. ...
... this week at the annual SLEEP meeting showing the ... healthcare professionals job performance and patient safety. The ... quarter of nurses (27.23%) suffered from insomnia; 32.10% had ... 55.38% suffered from a combination of both symptoms. ...
Cached Medicine News:Health News:Healthcare Workers Could Be Africa's Secret Weapon in AIDS War 2Health News:Men and Women Change Attitudes to Sex When in an Intimate Relationship 2Health News:Men and Women Change Attitudes to Sex When in an Intimate Relationship 3Health News:New International Health Regulations to Enter into Force Tomorrow 2Health News:Insomnia Affects Job Performance A New Survey 2
The WatchMate MR model displays multiple alarms locally without individual identification, but ID numbers and names can be displayed at a central station. Alarms may be cleared locally under password...
... of door controllers, RoamAlert Integrity Plus adds ... coverage area. These receivers pick up the ... in size and shape, this tag differs ... ECO and RoamAlert Integrity in one way: ...
... Awarix provides an enterprise visibility solution ... improve caregiver effectiveness, and increase patient ... RFID location systems and geospatial visual ... to create a real time patient ...
MONOJECT SUPRA/HONE Blood Collection Needles - Thin Wall...
Medicine Products: