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Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)
Date:3/3/2009

ectly with those previously reported by Professor Blas Frangione and his colleagues from New York University more than ten years ago regarding a direct physical interaction between the beta amyloid protein and melatonin, a close structural homolog of OXIGON(TM). The interaction was shown to involve four specific amino acids, which now are known to comprise the high affinity copper binding site in the beta amyloid protein. Professor Hong's findings provide the missing link to explain the biochemical significance of these earlier findings, from which we gain additional insight into the mechanism of action of our drug candidate. OXIGON(TM) is considerably more potent than melatonin in blocking beta-amyloid neurotoxicity and offers several other pharmacological advantages."

"Neurotoxicity observed in AD is believed to be related to the toxicity from reactive oxygen species produced in the brain by beta-amyloid protein bound primarily to copper ions," commented Professor Kelvin Davies Chairman of the Company's Scientific Advisory Board. Dr Davies is the James E. Birren Chair in Gerontology and is Professor of Molecular & Computational Biology at the University of Southern California. Professor Davies added: "Moreover, the so-called 'redox activity' of the bound metal ion can lead to the formation of soluble neurotoxic oligomers as well as fibrillar forms of the protein, which eventually deposit as plaques in the brains of AD patients. This important new finding that the OXIGON(TM) molecule can bind metal ions such as copper is highly suggestive of a mode of action in common with other compounds, referred to as metal protein attenuating compounds, which have begun to show promising proof of concept in human clinical trials." Professor Davies concluded: "We believe that OXIGON(TM), which appears to be well tolerated in humans and enters the brain, is an especially promising drug candidate with broad therapeutic potent
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SOURCE Intellect Neurosciences, Inc.
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