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Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa®
Date:10/10/2010

nt visits, emergency room (ER) visits, nursing home/long-term care facility stays, home health visits, procedures, and medications. This interim analysis included 206 eligible patients with 387 discrete SREs.

Bone Metastases and Skeletal Related Events (SREs): Prevalence and Impact Bone metastases occur in more than 1.5 million patients with cancer worldwide and are most commonly associated with cancers of the prostate, lung, and breast, with incidence rates as high as 75 percent of patients with metastatic disease.(ii)

Approximately 50-70 percent of cancer patients with bone metastases will experience debilitating SREs.(iii)(iv)(v) Events considered to be SREs include fractures, spinal cord compression, and severe bone pain that may require surgery or radiation(vi). Such events can profoundly disrupt a patient's life and can cause disability, pain or even death. (vii)(viii)(ix)

Patients who experience an SRE as a result of bone metastases incur significantly higher medical costs compared with those who do not experience such events.(x)(xi)(xii) Studies have shown that the costs of treating a SRE are significant.(x)(xiii)  In fact, the total economic burden of patients with bone metastases in the U.S. alone is estimated to be $12.6 billion annually.(xiv)

About Denosumab and Amgen's Research in Bone BiologyDenosumab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). The denosumab development program is the largest ever initiated by Amgen. This broad and deep development program demonstrates Amgen's commitment to researching and delivering pioneering medicines to patients with unmet medical needs. Amgen is studying denosumab in numerous tumor types across the spectrum of cancer-related bone diseases. Over 11,000 patients have been enrolled in the denosumab oncology clinical trials,
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SOURCE Amgen
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