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Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa®
Date:10/10/2010

igns that metastatic disease has spread to the skeleton, and affects approximately 70 percent of patients with metastatic disease.(i) Patients enrolled in the three studies completed the Brief Pain Inventory (range 0-10) to assess pain severity at baseline (BL), day 8, and monthly through the end of the studies (week 41).

Time to worsening of clinically significant pain was significantly delayed with denosumab compared to Zometa (median of 181 days for denosumab, median of 169 days for Zometa) (hazard ratio 0.92, 95 percent CI 0.86-0.99, p=0.026). In patients with no or mild pain at BL, denosumab prolonged the median time until moderate or severe pain by 55 days compared to Zometa (198 days denosumab, 143 days Zometa) (hazard ratio 0.83, 95 percent CI 0.76–0.92, P=0.0002). The time to pain improvement was similar in both treatment groups (86 days for denosumab, 85 days for Zometa) (hazard ratio 0.99; 95 percent CI 0.92–1.07; p=0.844).

Multinational Study Illustrates Resource Utilization Varies by Skeletal Related Event SREs have an adverse financial impact on healthcare systems, consuming significant resources. Results from the first interim analysis of a multinational observational study assessing the utilization of health resources by type of SRE showed that pathologic fractures resulted in the longest hospital stay (16.3 days), with both spinal cord compression and radiation to bone resulting in the next longest hospital stay (9.3 days). Meanwhile, radiation to bone resulted in the highest number of outpatient visits (10.0) and overall procedures (e.g., imaging) (13.5).

The ongoing observational, multinational study assessed SRE-related utilization of health resources by SRE type (surgery or radiation to bone, pathologic fracture, or spinal cord compression) in prostate, breast or lung patients with bone metastases, or in patients with multiple myeloma. Data was collected on inpatient hospitalizations, length of stay, outpatie
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SOURCE Amgen
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