Navigation Links
Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa®
Date:10/10/2010

ed analysis of these trials, which together enrolled more than 5,700 patients, provided a clear view of the efficacy and safety profile of denosumab in a large and diverse group of people living with cancer and bone metastases.

The analysis showed that denosumab was superior to Zometa in delaying time to first on-study SRE by 17 percent (median time to first skeletal related event of 27.7 months for denosumab and 19.5 months for Zometa, p <0.0001). Denosumab was also superior to Zometa in delaying time to first-and-subsequent on-study SRE by 18 percent (p<0.0001). Overall disease progression and survival were similar for both groups.

Overall, the occurrence of adverse events (96.2 percent denosumab, 96.8 percent Zometa) and serious adverse events (56.3 percent denosumab, 57.1 percent Zometa) were balanced in both groups and consistent with what has previously been reported for these two agents.

Osteonecrosis of the jaw (ONJ) occurred infrequently, 1.8 percent of denosumab patients and 1.3 percent of Zometa patients (p=0.13) experienced this adverse effect. In addition, Zometa-treated patients had increased rates of adverse events potentially associated with renal toxicity (2.6 percent higher) and increased rates of acute phase reactions (8.7 percent denosumab, 20.2 percent Zometa). As with previous studies in advanced cancer patients, hypocalcemia was more frequent in the denosumab arm (9.6 percent denosumab, 5.0 percent Zometa).

Patients received either 120 mg of denosumab subcutaneously every four weeks or Zometa administered intravenously as at least a 15 minute infusion at a dose of 4 mg every four weeks, per the labeled instructions.

Integrated Pain Analysis Shows Denosumab Superior to Zometa A separate integrated analysis of the three Phase 3 trials found that denosumab was superior to Zometa in preventing clinically relevant increases in pain, as reported by trial participants. Bone pain is one of the first s
'/>"/>

SOURCE Amgen
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Self Regional Healthcare Becomes First in the Southeast to Treat Spine Patients Using Advanced Integrated Operating Room Technology From Brainlab
2. Molecular Detection and Integrated Sciences Announce Distribution Agreement for Detect-Ready™ MRSA Assay in Australia
3. Oridion to Present Results to New Study for the Integrated Pulmonary Index(TM) at ATACCC Conference
4. StatRad Raises the Bar With Fully Integrated Teleradiology Solution
5. Brainlab Collaborates With Toshiba Medical Systems on Integrated Surgical Suite
6. Highmark Study Shows Integrated Medical and Pharmacy Benefits Lower Costs, Promote Better Health
7. Stereotaxis and Siemens Promote Integrated Odyssey(TM) Solutions
8. RedVision Announces Integrated Client Workflow Platform: TitleVision2 The Power of Two
9. Texas Instruments unveils fully integrated analog front end for ECG and EEG applications
10. Feintuch Communications Launches Integrated PR and IR Practice for Healthcare and Life Sciences Organizations
11. New York States Largest Integrated Health System Chooses Craneware Revenue Integrity Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... , Jan. 15, 2014  Novation, the leading health ... several new IT value-added reseller (VAR) national contracts that ... goods and services at lower costs. These include manufacturer ... such as initiative assistance and ongoing IT consulting support. ...
(Date:1/15/2014)... Jan. 15, 2014  Humberto C. Antunes,  Galderma  worldwide CEO, ... the Journal of Drugs in Dermatology (JDD) ... (ODAC). The event is January 17-20, 2014, at the Omni Orlando ... The ODAC is a distinguished event ...
(Date:1/15/2014)... , Jan. 15, 2014 Tegra Medical is very pleased ... as its new Chief Executive Officer.  Mark was promoted ... he has overseen the company,s four facilities in ... Rica.  Mr. King joined Tegra Medical in 2012 with 20+ ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3
... Surgical Information Systems ("SIS"), a leader in ... Health System has extended its enterprise agreement with ... solution. The implementation will start at North Shore University ... Health Systems hospitals. (Logo:   http://photos.prnewswire.com/prnh/20080722/SISLOGO ...
... 2011 Mitsubishi Chemical Medience Corporation announced today ... has granted 510(k) premarketing notification clearance to the ... the way for its sale in the United ... with the PATHFAST analysis system, a unique, self-contained, ...
Cached Medicine Technology:North Shore-LIJ Health System Selects SIS Anesthesia 2North Shore-LIJ Health System Selects SIS Anesthesia 3North Shore-LIJ Health System Selects SIS Anesthesia 4Mitsubishi Chemical Medience Corporation Receives 510(k) Clearance for PATHFAST® cTnI-II (cardiac Troponin I) Test in U.S. 2Mitsubishi Chemical Medience Corporation Receives 510(k) Clearance for PATHFAST® cTnI-II (cardiac Troponin I) Test in U.S. 3
(Date:4/24/2014)... The University of Manchester have identified a way to ... open to treatment. , The study published today in ... the development of drugs to target cells that have ... the discovery whilst exploring the possible mechanisms behind resistance ... breast and colon cancer. , Dr Andrew Gilmore, who ...
(Date:4/24/2014)... April 24, 2014 Scientific research at UT ... heart can heal itself completely, whereas the adult heart ... today has revealed why the heart loses its incredible ... simple oxygen. , Yes, oxygen. It is ... to circulate oxygen-rich blood throughout the body. But at ...
(Date:4/24/2014)... lenses coated with an antimicrobial peptide could help to lower ... Optometry and Vision Science , official journal ... journal is published by Lippincott Williams & Wilkins , ... in animals and now humans support the biocompatibility and safety ... the new research by Debarun Dutta, B.Optom, of The University ...
(Date:4/24/2014)... Changes in managing patients before, during and after ... reduced readmission rates, according to researchers who led a ... The practice, called enhanced recovery, is easier on patients ... bowel evacuation that are typically prescribed. After surgery, patients ... as possible, leading to faster recoveries. , Among findings ...
(Date:4/24/2014)... a professor in the new Institute for Biomedical ... five-year, $2.83 million federal grant to develop novel ... The grant from the Eunice Kennedy Shriver National ... the National Institutes of Health will support Plemper,s ... and at least one distinct alternative compound. , ...
Breaking Medicine News(10 mins):Health News:Scientists find way to target cells resistant to chemo 2Health News:Oxygen diminishes the heart's ability to regenerate, researchers discover 2Health News:Study supports safety of antimicrobial peptide-coated contact lenses 2Health News:Study supports safety of antimicrobial peptide-coated contact lenses 3Health News:New approach for surgery patients cuts hospital stays and costs 2Health News:New approach for surgery patients cuts hospital stays and costs 3
... outlines key financial concerns, including Social Security disability, for ... Conference in Atlanta. , ... ... The diagnosis of a long-term degenerative disease like ...
... the Award Winning ... CytoViva Nano-scale Microscope, ... provider,of optical imaging solutions to the nano-technology research market, ... scale microscope system. This combination of technologies enables,scientists to ...
... Cleveland Clinic ... Expertise Anywhere in the World, CLEVELAND, Aug. 21 ... provides specialized care by,Cleveland Clinic physicians, nurse practitioners and critical ... intensive,care unit, helicopter and fixed-wing jets., With the launch ...
... 21 Bruce Bodaken,Chairman, President & CEO of Blue ... 2008 Rocky Mountain Roundtable on Health, Wellness and,Prevention at ... 25, 2008, 9:30 a.m. MDT at Boettcher Hall in ... importance of wellness programs,in health reform, and the ways ...
... Fairview and,Blue Cross and Blue Shield of Minnesota ... clinics to remain as participating providers,in all of Blue ... expire at midnight on Friday, August 22, 2008. Agreement ... participating network,hospitals with the Blue Cross network. The hospital ...
... It means different things to youngsters, so sex ed ... THURSDAY, Aug. 21 (HealthDay News) -- One reason why ... activity is because abstinence can mean different things to ... University of Washington study. , Teens, attitudes and intentions ...
Cached Medicine News:Health News:Five Steps for Staying in Financial Control with Long-Term Disability 2Health News:Five Steps for Staying in Financial Control with Long-Term Disability 3Health News:Five Steps for Staying in Financial Control with Long-Term Disability 4Health News:CytoViva(R) Introduces Breakthrough Nano-Technology Research Tool 2Health News:Cleveland Clinic Launches Fully Dedicated International Comprehensive Critical Care Program 2Health News:Cleveland Clinic Launches Fully Dedicated International Comprehensive Critical Care Program 3Health News:Blue Shield of California CEO to Speak at Democratic Convention Host Committee's Health Roundtable in Denver 2Health News:Abstinence-Only Programs Fall Short of Teens' Needs 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: