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Instrumentation Laboratory Introduces Automated HemosIL VWF Ristocetin Cofactor Activity Assay in Europe and International Regions
Date:11/29/2011

roximately 1% of the general population.  It disrupts the blood's ability to clot properly.  Unlike hemophilia, it affects both genders and is caused by a quantitative defect (i.e., VWF level is abnormally low) or a qualitative defect (i.e., VWF has abnormal physical characteristics) of the VWF.   A large protein involved in primary hemostasis, VWF helps platelets stick to damaged vessel walls and carries the clotting protein, Factor VIII, in the blood.  Excessive or prolonged bleeding can be a sign of VWD.  For those with a moderate-to -severe form of the disease, proper diagnosis and treatment is essential.  Acquired von Willebrand Syndrome (AVWS) can also occur as a direct consequence of other medical disorders.  Laboratory findings in AVWS are similar to those in VWD and may include decreased values for VWF:Ag, VWF:RCo, or FVIII.

Principle of the HemosIL VWF:RCo Assay

HemosIL VWF:RCo assay detects quantitative and qualitative VWF defects (VWD Type 1, 2 and 3).  It is based on the principle that a recombinant fragment of the platelet receptor, glycoprotein-Ib alpha contains the VWF-binding site.  The VWF:RCo reagent consists of a latex particle, coated with glycoprotein-Ib alpha, through a highly specific monoclonal antibody.  If VWF is present in the sample, it will bind to the glycoprotein-Ib alpha fragment, in the presence of ristocetin.  The degree of agglutination is directly proportional to the activity of VWF in the sample, and is determined by measuring the decrease of transmitted light caused by the aggregates.

HemosIL VWF:RCo Assay is not currently 510(k) cleared.

Instrumentation Laboratory (www.ilus.com), founded in 1959, is a worldwide developer, manufacturer and distributor of in vitro diagnostic instruments, related reagents and controls for use primarily in hospitals and independent clinical laboratories.&
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