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Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain


Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio. Its R&D is structured around partnerships and in-licensing is a cornerstone of the company's growth strategy.

Nycomed employs 12,000 associates worldwide, and its products are available in more than 100 countries. It has strong platforms in Europe and in fast-growing markets such as Russia/CIS and Latin America. While the US and Japan are commercialised through best-in-class partners, Nycomed plans to further strengthen its own position in key Asian markets.

Headquartered in Zurich, Switzerland, the company generated total sales of EUR3.4 billion in 2008 and an adjusted EBITDA of EUR1.2 billion.

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    About the study

    - A multinational, open-label, crossover trial comparing Instanyl(R) and
      Actiq(R) for breakthrough cancer pain in patients receiving chronic
      opioid treatment.

    - The trial investigated the efficacy of Instanyl compared to Actiq as
      well as ease of administration and patient preference.

    - Primary efficacy measurement was time to onset of meaningful pain

    - Of 196 patients enrolled and 139 randomised, 86 patients completed the

    Results showed that:

    - 25.3% of episodes showed meaningful pain relief (greater than or equal
      to 33% reduction in PI score) at 5 minutes after treatment with
      Instanyl versus 6.8% with Actiq.

    - 51% of the Instanyl treated patients had a meaningful pain relief
      (greater than or equal to 33% reduction in PI score) at 10 minutes
      versus 23
SOURCE Nycomed
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