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Inspiration Biopharmaceuticals Presents Key Scientific Data from its Two Lead Hemophilia Development Programs at the 53rd Annual Meeting of the American Society of Hematology (ASH)
Date:12/12/2011

LAGUNA NIGUEL, Calif., Dec. 12, 2011 /PRNewswire/ -- Inspiration Biopharmaceuticals, Inc. (Inspiration) has presented key scientific data from the Company's two lead hemophilia development programs - IB1001, a recombinant factor IX (FIX) product, which is in clinical trials for the treatment and prevention of bleeding in individuals with hemophilia B; and OBI-1, an intravenous recombinant porcine factor VIII (FVIII) product, which is being evaluated for the treatment of individuals with congenital hemophilia A who have inhibitors against human FVIII, and for individuals with acquired hemophilia A.  The data were highlighted in poster presentations at the 53rd Annual Meeting of the American Society of Hematology (ASH) in San Diego, California.

In a poster presentation titled, "Pharmacokinetic Behavior of IB1001, An Investigational Recombinant Factor IX, in Patients with Hemophilia B: Repeat Pharmacokinetic Study and Subgroup Analysis", newly reported data from a subset of patients who underwent a second pharmacokinetic (PK) evaluation with IB1001 demonstrated the PK profile of IB1001, following prophylaxis over periods ranging from 4 to 18 months, was similar to the profile established during the initial phase of the study.  Importantly, these findings indicate there was no evidence of development of inhibitors during prophylactic treatment.  The initial randomized cross-over PK study demonstrated that IB1001 is at least as good as BeneFIX®, the only approved recombinant FIX product for the treatment of hemophilia B in achieving circulating levels of factor IX.

Ed Gomperts, M.D., Medical Director of Inspiration Biopharmaceuticals, commented, "One of Inspiration's primary missions is to improve access to care, including prophylactic therapy for patients with hemophilia.  These new data suggest IB1001 may be safely and effectively administered during prophylaxis therapy to prevent bleeds and on demand when
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SOURCE Inspiration Biopharmaceuticals
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