Navigation Links
Insmed Provides Update on Follow-On Biologics and IPLEX(TM) Programs
Date:4/29/2008

an earlier stage of cell line development and product characterisation.

IPLEX(TM)

IPLEX(TM) is a complex of recombinant human insulin-like growth factor-I (rhIGF-I) and its predominant binding protein IGFBP-3 (rhIGFBP-3). The drug, approved in the United States in December 2005 for the treatment of children with growth failure due to severe primary IGF-I deficiency, is currently being investigated in Myotonic Muscular Dystrophy (MMD) and Amyotrophic Lateral Sclerosis (ALS), or Lou Gehrig's disease.

A Phase 2 trial of IPLEX(TM) in MMD is on-going and a substantial portion of the external costs associated with the study are expected to be covered by an approximately $2.1 million grant awarded to Insmed by the Muscular Dystrophy Association in late 2007.

MMD Phase 2 trial at-a-glance:

-- All sites have been initiated, received Investigational Review Board

approvals and are actively recruiting trial participants.

-- The trial is currently more than 50 percent enrolled.

-- The trial is on target to complete enrollment by mid-year 2008

-- Interim data analysis scheduled for fourth quarter 2008.

IPLEX(TM) is also in use as part of an Expanded Access Program (EAP) in partnership with the Italian Ministry of Health for the treatment of ALS. Since early 2007, the EAP has grown to include 20 physicians, and approximately 90 subjects have been enrolled into the program to date with additional subjects being enrolled as the program progresses. IPLEX(TM) continues to be safe and well tolerated in the subject population. During the first quarter of 2008, the EAP generated $2.3 million in cost recovery revenue for Insmed, compared to $0.7 million during the same period last year, and $2.0 million in the fourth quarter of 2007.

"We are pleased with the development progress and results to date of IPLEX(TM) in both MMD and ALS, especially considering the level of investment these therapeutic programs cur
'/>"/>

SOURCE Insmed Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Insmed Receives FDA Orphan Drug Designation for IPLEX(TM) in the Treatment of Myotonic Muscular Dystrophy
2. Insmed Provides Update on IPLEX(TM) Expanded Access Program in Italy for the Treatment of Amyotrophic Lateral Sclerosis
3. Insmed Launches National Awareness Campaign Surrounding Follow-On Biologics
4. Insmed Initiates Clinical Study for Follow-on Biologic Version of Neupogen(R)
5. CuraGen Provides Update on Velafermin, Belinostat and CR011-vcMMAE Clinical Development Programs
6. Access Pharmaceuticals Provides Update on Clinical Development Plan of ProLindac
7. Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years
8. Raptor Pharmaceuticals Provides Update of Product Programs
9. Monogram Provides Update on Trofile(TM) Co-Receptor Tropism Assay
10. Arbios Provides Clinical Strategy for SEPET(TM) Pivotal Trial
11. Innocoll Provides a Progress Update on its Clinical Development Programs and Specialty Pharmaceutical Operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... InformEx, North America,s leading business ... hold the 30 th edition of its annual conference ... from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... chemical and specialty chemical companies will take part in the ...
(Date:1/14/2014)... Animal Emergency Critical Care, a LifeCentre partner practice, located at 165 ... the first in Loudoun County to receive ... Susan M. Barnes , Medical Director, is a well-seasoned veterinarian of ... Taylor , are avid scuba divers. "As altitude skiers and hikers, ...
(Date:1/14/2014)... 14, 2014 Equashield ( http://www.equashield.com ... drugs, today announced that it has achieved 60% ...   Equashield,s closed systems reduce the ... and other medical professionals who prepare and administer ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Equashield's Sales Grow by 60% in 2013 2
... Resources, one of the world,s leading research and ... that the increased generic erosion of key drugs ... (Abbott/Sanofi-Aventis,s Depakote/Abbott,s Depakote ER, generics), combined with projected ... will cause a precipitous $2.3 billion decline in ...
... Aug. 25 Actelion Pharmaceuticals US, Inc., today ... (FDA) has approved the brand name VELETRI® for the ... available since April 2010 as Epoprostenol for Injection for ... (PAH) and PAH associated with the scleroderma spectrum of ...
Cached Medicine Technology:Through 2019, Increased Generic Erosion of Key Agents Such as Lamictal and Depakote/Depakote ER Will Cause a Precipitous $2.3 Billion Decline in the Bipolar Disorder Drug Market 2Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension 2Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension 3Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension 4
(Date:7/9/2014)... WASHINGTON, DC (July 10, 2014) If you think winning ... fun for kids think again: Winning along with other mental ... each of which falls into one of 11 big fun ... that winning is all important when it comes to the ... identify and quantify what goes into this elusive conceptuntil now. ...
(Date:7/9/2014)... Boston, MA -- Vasectomy was associated with a small ... for advanced or lethal prostate cancer according to a ... The researchers found that the association remained even among ... risk of lethal cancer cannot be explained by diagnostic ... to date to look at the link between vasectomy ...
(Date:7/9/2014)... hidden ways that cells are regulated, scientists at Rockefeller ... cells more likely to metastasize. , What,s more, the ... blocking two other proteins that are normally linked to ... could have unexpected ties. , The study, which ... , points to the possibility of new cancer therapies ...
(Date:7/9/2014)... fecal transplantation is effective and safe for treating ... result of a study led by Colleen Kelly, M.D., ... at The Women,s Medicine Collaborative. The study and its ... in the American Journal of Gastroenterology . , ... has increased to epidemic proportions over the past decade. ...
(Date:7/9/2014)... in French . ... old teens, including brain structure and function, personality, life experiences ... go on to develop binge drinking within the next two ... variables such as life events and a family history of ... Whether or not the child had had a single drink ...
Breaking Medicine News(10 mins):Health News:Being a good sport ranks as the top 'fun' factor in study of youth sports 2Health News:Being a good sport ranks as the top 'fun' factor in study of youth sports 3Health News:Vasectomy may increase risk of aggressive prostate cancer 2Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3Health News:Women's Medicine Collaborative examines safety of fecal transplant to treat C. difficile 2Health News:What drives a child to abuse alcohol? 2
... autism experts Fred R. Volkmar, M.D., and Ami Klin are ... identified an individual gene and a// region of a chromosome ... findings are published online in Nature Genetics and also will ... based on the largest autism genome scan done to date. ...
... could be prone to certain pregnancy related complications later on ... women carry a 60% possibility of suffering from pre-eclampsia, a ... and her unborn baby. ,The risk was ... low birth weight and whose mothers suffered pre-eclampsia during pregnancy. ...
... its ability to “bridge” interactions between other cellular proteins ... stage, a study from Burnham Institute for Medical Research ... Ph.D., and colleagues at Burnham and Royal Victoria Hospital ... to more precisely define the cancer role for the ...
... allegedly refused treatment by doctors at premier state-run Kolkata ... medical negligence to support him., ,Sk. Idrish Ali, ... approached the People for Better Treatment (PBT) set up ... refused to perform a surgery on his son for ...
... offices portray it as the hot new baby-shower gift: a ... start// privately banking a newborn's umbilical cord blood, just in ... insurance is a long shot that most mothers-to-be can safely ... more parents to donate their babies' cord blood -- so ...
... (AMANET) has secured a US$4.1million grant to strengthen institutional ... ,The fund will also be used to foster ... perspectives. , ,AMANET's communications officer, Mr. Charles ... week that the grant secured from the Bill and ...
Cached Medicine News:Health News:Autism Gene Identified by Yale and Global Consortium 2Health News:“Bridge” Protein Spurs Deadliest Stages of Breast Canc 2Health News:NRI Fights for HIV Child Who was Refused Treatment 2Health News:Parents Bank Kids' Umbilical Cord Blood 2Health News:Parents Bank Kids' Umbilical Cord Blood 3
... when rotated at 8-10 rpm. Drums ... Light weight drum of professional quality ... mechanism. For use 24 to 30 ... and Pediatric Drums that can be ...
Sterile squares of textured nylon foil for repair of the floor of the orbit....
Diagnose dry eye, assess the effectiveness of permanent punctal occlusion, collagen - dissolvable in 3-5 days, all are 2 mm long. Sterile...
Segment stand magnifiers come complete with bar magnifier to achieve a higher magnification while still maintaining a wide binocular field of view....
Medicine Products: