Navigation Links
Insero Health Completes Phase I Trial of Novel Therapy in Patients With Drug Resistant Epilepsy
Date:12/13/2012

MIAMI, Dec. 13, 2012 /PRNewswire/ -- Insero Health, Inc., a company developing natural compounds to address unmet medical needs in neurological disorders, today announced that it has completed a Phase Ib trial of its lead compound INS001 in patients with drug-resistant epilepsy.  Insero also reported that two key US patents licensed from Harvard University have issued, and the company announced the formation of its Scientific Advisory Board (SAB).

INS001, also known as huperzine A, is a naturally-occurring compound that has shown promising activity in preclinical epilepsy models.  It has previously demonstrated good safety and signs of therapeutic activity in a Phase II trial in Alzheimer's disease and in preclinical models of multiple sclerosis and neuropathic pain.

The Phase lb epilepsy trial included dose ranging assessments, as well as biomarkers chosen to provide information on the potential therapeutic activity and cardioprotective properties of INS001.  Insero expects to report the results of the Phase Ib trial in the next few months and to initiate Phase II proof-of-principle trials by early 2014.

Epilepsy affects about three million people in the United States and over 50 million people worldwide. Many people with epilepsy take multiple medications, yet the published literature suggests that as many as one-third are unable to control their seizures with current therapy.  INS001 has a unique mechanism of action, which suggests it may provide superior efficacy either as a stand-alone therapy or when given in combination with other epilepsy drugs.

The two newly-issued patents were exclusively licensed to Insero by Harvard University and cover the use of INS001 as a treatment for epilepsy and other indications.  The company also has licensed technology patents from Yale University and the University of South Florida.  In addition, Insero is continuing its research programs related to its library of over 5,000 proprietary compounds, including screening for potential utility in epilepsy and other related neurological disorders.

The inventor of the newly-issued patents and Chairman of Insero's Scientific Advisory Board, Dr. Steven Schachter, is an eminent Harvard Medical School epileptologist and Chief Academic Officer of CIMIT, a non-profit consortium of Boston's leading teaching hospitals and universities.  Dr. Schachter noted, "I am pleased that the first trial of INS001 in epilepsy is now complete.  This is a significant milestone and step forward in the clinical development of this therapy with worldwide potential for patients with epilepsy."

Dr. Schachter and Insero also announced the membership of its SAB, which includes:

  • Roger Porter, MD, Chief Scientific Officer of the Epilepsy Therapy Project and previously Chief of the Epilepsy Branch, Chief of the Medical Neurology Branch and Deputy Director of the US National Institute of Neurological Disorders and Stroke.
  • Michael Rogawski, MD, PhD,  Professor of Neurology at the University of California, Davis, and previously Chief of the Epilepsy Research Section at the US National Institutes of Neurological Disorders and Stroke.
  • H. Steve White, PhD, Professor of Pharmacology and Toxicology at the University of Utah College of Pharmacy, and Principal Investigator and Scientific Director of the US National Institutes of Health-sponsored Anticonvulsant Drug Development Program.
  • Seth Herzon, PhD,  Assistant Professor of Chemistry at Yale University, whose research focuses on the synthesis and study of complex natural products and the development of new synthetic methods.
  • "We are awaiting detailed analyses of our first clinical trial of lead compound INS001 in patients with treatment resistant epilepsy, but top-line data from the trial have already provided us with valuable insights into the potential of this promising compound, which should enable us to advance it into Phase II studies with a good sense for likely dosing and potential activity parameters," commented David Kolb, CEO of Insero Health.  "We are also delighted to announce the formation of our SAB, chaired by renowned neurologist and epilepsy opinion leader Steven Schachter.  Dr. Schachter has helped us to assemble some of the most respected thinkers in the field, and we are honored to have these individuals working with us toward our goal of improving the lives of people with debilitating neurological diseases."

    About Insero Health
    Insero Health is a clinical-stage company that discovers and develops small molecule therapies derived from natural products to address significant unmet needs in neurological diseases.  The company's initial target is epilepsy, a debilitating disorder that affects approximately 3 million people in the United States and over 50 million people worldwide.  Insero researchers believe that the unique mechanism of lead product INS001 may provide enhanced anti-seizure efficacy without the side effects of current therapies. The company is based in Miami, Florida, at the University of Miami Life Science and Technology Park. For more information, visit www.inserohealth.com.Contacts:Insero Health Corporate: 

    Media: David Kolb 

    BLL Partners, LLCCEOBarbara Lindheim786 300-4600 

    212 584-2276 dkolb@inserohealth.com 

    blindheim@bllbiopartners.com


    '/>"/>
    SOURCE Insero Health, Inc.
    Copyright©2012 PR Newswire.
    All rights reserved

    Related medicine technology :

    1. HealthSouth Declares Dividend on 6.5% Series A Convertible Perpetual Preferred Stock
    2. GlaxoSmithKline advances multi-city discussion focused on improving the health of US communities
    3. BodyMedia Collaborates on Federal Health Research Study
    4. AssureRx Health Expands Management Team to Support Increasing Business Growth
    5. Hospira to Present at the J.P. Morgan 31st Annual Healthcare Conference Jan. 8, 2013
    6. Thoratec Presentation At Oppenheimer 23rd Annual Healthcare Conference To Be Webcast
    7. STATEMENT OF CHAIRMAN AND CEO GEORGE BARRETT FORTUNE 21 CARDINAL HEALTH REGARDING FISCAL CLIFF
    8. inVentiv Health Strengthens Clinical Leadership Team
    9. USANA True Health Foundation: Musician Donates Proceeds Of Holiday Song To Charity
    10. Henry Schein To Present At The Oppenheimer 23rd Annual Healthcare Conference
    11. Health Outcomes Liaisons Key to Pharmaceutical Sector Navigating Payer-Focused Marketplace
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
    (Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
    (Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
    Breaking Medicine Technology:
    (Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
    (Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg ... Legal Elite. The attorneys chosen by their peers for this recognition are considered among ... Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite Hall ...
    (Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
    (Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
    (Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the placement of ... President of North American Capital Sales at HTG Molecular . , ... the commercialization of the HTG EdgeSeq system and associated reagents in North America. , ...
    Breaking Medicine News(10 mins):