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Insero Health Completes Phase I Trial of Novel Therapy in Patients With Drug Resistant Epilepsy
Date:12/13/2012

MIAMI, Dec. 13, 2012 /PRNewswire/ -- Insero Health, Inc., a company developing natural compounds to address unmet medical needs in neurological disorders, today announced that it has completed a Phase Ib trial of its lead compound INS001 in patients with drug-resistant epilepsy.  Insero also reported that two key US patents licensed from Harvard University have issued, and the company announced the formation of its Scientific Advisory Board (SAB).

INS001, also known as huperzine A, is a naturally-occurring compound that has shown promising activity in preclinical epilepsy models.  It has previously demonstrated good safety and signs of therapeutic activity in a Phase II trial in Alzheimer's disease and in preclinical models of multiple sclerosis and neuropathic pain.

The Phase lb epilepsy trial included dose ranging assessments, as well as biomarkers chosen to provide information on the potential therapeutic activity and cardioprotective properties of INS001.  Insero expects to report the results of the Phase Ib trial in the next few months and to initiate Phase II proof-of-principle trials by early 2014.

Epilepsy affects about three million people in the United States and over 50 million people worldwide. Many people with epilepsy take multiple medications, yet the published literature suggests that as many as one-third are unable to control their seizures with current therapy.  INS001 has a unique mechanism of action, which suggests it may provide superior efficacy either as a stand-alone therapy or when given in combination with other epilepsy drugs.

The two newly-issued patents were exclusively licensed to Insero by Harvard University and cover the use of INS001 as a treatment for epilepsy and other indications.  The company also has licensed technology patents from Yale University and the University of South Florida.  In addition, Insero is continuing its research programs related to its library
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SOURCE Insero Health, Inc.
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