Navigation Links
Inovio's Universal H7N9 DNA Vaccine Generates First Protective Antibody Responses Against Virulent H7N9 Virus in 100% of Vaccinated Animals
Date:6/14/2013

w rapidly we can create a DNA vaccine construct to address a new global threat." 

In the preclinical study Inovio researchers constructed a consensus DNA vaccine targeting the HA influenza antigen from sequences collected from several infected H7N9 patients to be broadly protective against all H7N9 viruses. The vaccine was designed, optimized, and manufactured within two weeks, and mice were immunized intramuscularly with two doses followed by electroporation three weeks apart. In an interim analysis, researchers tested sera from the animals against an unmatched H7N9 influenza strain, A/Anhui/1/13. The researchers observed levels of HAI titers, or functional antibodies, that predict protection against the H7N9 virus as well as robust levels of binding antibodies which can block virus entry into host cells as well as inhibit other viral functions.

Generating these very strong immune responses against an unmatched influenza strain adds further to the growing data set indicating the universal protective capability that Inovio's SynCon® DNA vaccines are able to achieve within targeted subtypes. While this study demonstrates that Inovio can respond to an urgent need to address a new subtype of influenza, it also provides further validation of its approach to address the more important need of providing truly preemptive and broad long-term protection against the constant strain mutations that occur within influenza subtypes. The ideal outcome would be to achieve a universal influenza vaccine capable of broad protection against existing and newly emergent unmatched strains across subtypes known to threaten humans.

Using our synthetic consensus design approach, we have created DNA "constructs" for key virus clades (branches) within the Type A subtypes H1N1, H2N2, H3N2, and H5N1 as well as Type B, and target multiple influenza antigens associated with influenza, including the most frequently changing antigen, HA. We c
'/>"/>

SOURCE Inovio Pharmaceuticals Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Finesse Solutions Launches Next Generation G3Lab Universal SmartControllers to Enhance Productivity in Bench Scale Cell Culture and Fermentation
2. Flexpoint Announces Universal Settlement Involving the Medical Bed and Related Technologies
3. Inovio Pharmaceuticals Universal H1N1 Influenza Vaccine Achieves Protective Immune Responses Comparable to Conventional Vaccine in Phase I Study
4. Inovio Pharmaceuticals Takes Major Stride Toward Universal Influenza Vaccine
5. Inovio Initiates H1N1 Universal Influenza Vaccine Clinical Trial Targeting Over-65 Population, Which Represents 90% of Flu Deaths
6. Inovio Pharmaceuticals Universal Avian Flu Vaccine Generates Protective Antibody Responses Against Six H5N1 Viruses in Phase I Trial
7. ASCO Interview of MD Andersons Mittendorf on AE37 Breast Cancer Vaccine Now Available on Generex Websites
8. Adult and Adolescent Vaccines Market to 2018 Report - Promising Novel Candidates in Late-Stage Development and Prevnar Approval for Use in Adults to Drive Growth
9. Generex Announces ASCO Presentations of AE37 Vaccine Data; Potential Leading Immunotherapy Option for Breast Cancer Patients
10. Goodwin Biotechnology Announces Process Development Sub-Contract for an Anthrax Vaccine
11. Kaiser Permanente Study Finds New Pneumococcal Vaccine Appears to be as Safe as Previously Used Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 10, 2014   LabStyle Innovations Corp ... today announced the appointment of Professor Richard ... its Board of Directors. Prof. Stone ... experience to LabStyle as an entrepreneur, venture capitalist ... corporate governance expert. He currently serves on the ...
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
(Date:1/15/2014)... WASHINGTON , Jan. 15, 2014 AARP Foundation today ... support older adults suffering from the severe cold weather that ... are committed to helping those in need; so to support ... dollar-for-dollar contributions up to $250,000, which could mean up to ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
(Date:7/11/2014)... 11, 2014 Superior Labs announce the ... dietary supplements to aid in maintaining optimal digestive health ... facilitate metabolism of fat. Formulated and manufactured in the ... Extract is available in all-natural, vegetarian capsules, with each ... , Health Benefits of Artichoke Leaf Extract , Superior ...
(Date:7/11/2014)... Latham, New York (PRWEB) July 11, 2014 ... imaging as an integral part of each patient’s unique ... detailed analysis of the skin’s health and trouble areas ... a personalized aesthetic plan to be established. , Vectra ... during the consultation appointment, Vectra 3D uses a quick ...
(Date:7/11/2014)... Montreal, Canada (PRWEB) July 11, 2014 ... that redefines email management with its unique Netmail ... at Microsoft’s World Partner Conference (WPC), which will ... Center from July 13-17, 2014. During the show, ... Netmail, an email management solution that consolidates email ...
(Date:7/10/2014)... acids had healthier joints than those fed diets high ... to Duke Medicine researchers. , The findings, published in ... on July 11, 2014, suggest that unhealthy dietary fats ... osteoarthritis. , "Our results suggest that dietary factors play ... link between obesity and osteoarthritis," said Farshid Guilak, Ph.D., ...
(Date:7/10/2014)... One week ahead of its annual Board meeting, ... will extend compensation benefits to workers from two months’ ... as a result of factory remediation, effective immediately. ... the closure of five factories for remediation. Structural faults ... concerns. In May, the Alliance—in a 50/50 partnership with ...
Breaking Medicine News(10 mins):Health News:Artichoke Leaf Extract Released by SuperiorLabs Now Available on Amazon.com With 2 Day Prime Shipping 2Health News:Artichoke Leaf Extract Released by SuperiorLabs Now Available on Amazon.com With 2 Day Prime Shipping 3Health News:Williams Rejuva Center Includes Innovative Computer Imaging 2Health News:Netmail Heads to Washington, D.C. to Demonstrate New Release of Netmail 5.3 at WPC 2014 July 13-17, 2014 2Health News:Netmail Heads to Washington, D.C. to Demonstrate New Release of Netmail 5.3 at WPC 2014 July 13-17, 2014 3Health News:Omega 3 fatty acids lessen severity of osteoarthritis in mice 2Health News:Alliance for Bangladesh Worker Safety to Double Compensation for Displaced Factory Workers; Members Vote to Extend Wage Benefits from Two to up to Four Months 2
... , , KIBBUTZ SHAMIR, ... SHMR ) (" Shamir ") expects to issue its second quarter ... a conference call to discuss the results at 11:00 A.M. EDT that ... broadcast live as a listen-only webcast. To listen live, please go to ...
... , , BETHESDA, Md., Aug. 6 ... developing novel, proprietary antibodies for the treatment of cancer, inflammation ... second quarter and six months ended June 30, 2009. , ... Micromet achieved a number of significant milestones illustrating its continued ...
... revised higher based on solid year-to-date performance and, positive ... Aug. 6 /PRNewswire-FirstCall/ - SXC Health Solutions Corp. ("SXC" or the "Company") ... the three- and six-month periods ended June 30, 2009. Financial references are ... Q2 2009 Highlights, ------------------, - ...
... , , WILMINGTON, Mass., Aug. 6 DUSA Pharmaceuticals, ... highlights and second quarter financial results press release will be issued on Tuesday, August ... , , Tuesday, August 11 - 8:30 a.m. E.T. , ... 800.647.4314 , Password - DUSA , , ...
... ... two additional contracts to the RTP, NC-based life sciences company Entegrion, ... safety and availability of blood-derived products for treating combat injuries. ... essential in responding to traumatic injury, especially on the battlefield. ...
... , ... plans provided by GetOnlineQuotes.com offer the best value in the current marketplace. , ... Miami, FL (PRWEB) August ... by law, the AARP Medicare Supplement ( http://www.getonlinequotes.com/aarp-medicare-insurance.html ) rates offered by ...
Cached Medicine News:Health News:Shamir Optical Industry Ltd. to Host Conference Call Announcing Second Quarter of 2009 Earnings Results 2Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 2Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 3Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 4Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 5Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 6Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 7Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 8Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 9Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 10Health News:Micromet, Inc. Reports Second Quarter 2009 Financial Results 11Health News:SXC Health solutions announces record second quarter financial results 2Health News:SXC Health solutions announces record second quarter financial results 3Health News:SXC Health solutions announces record second quarter financial results 4Health News:SXC Health solutions announces record second quarter financial results 5Health News:SXC Health solutions announces record second quarter financial results 6Health News:SXC Health solutions announces record second quarter financial results 7Health News:SXC Health solutions announces record second quarter financial results 8Health News:SXC Health solutions announces record second quarter financial results 9Health News:SXC Health solutions announces record second quarter financial results 10Health News:SXC Health solutions announces record second quarter financial results 11Health News:SXC Health solutions announces record second quarter financial results 12Health News:SXC Health solutions announces record second quarter financial results 13Health News:SXC Health solutions announces record second quarter financial results 14Health News:SXC Health solutions announces record second quarter financial results 15Health News:SXC Health solutions announces record second quarter financial results 16Health News:SXC Health solutions announces record second quarter financial results 17Health News:SXC Health solutions announces record second quarter financial results 18Health News:SXC Health solutions announces record second quarter financial results 19Health News:U.S. Navy Awards Entegrion Contracts for $4 Million for the Development of Critical Blood Products 2Health News:U.S. Navy Awards Entegrion Contracts for $4 Million for the Development of Critical Blood Products 3Health News:GetOnlineQuotes.com to Offer AARP/United Healthcare Medicare Supplement Insurance to Florida Residents 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: