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Inovio's Synthetic Flu Vaccine Doubles Rate of Elderly Subjects Displaying Protective Immune Responses
Date:12/10/2012

this at-risk population of elderly subjects against flu. With limited evidence of other innovations enhancing protection against influenza, this technology could potentially lead to a breakthrough vaccine." 

Dr. J. Joseph Kim, Inovio's President and CEO, said, "Today's results provide evidence of the power of our DNA vaccine approach to generate protective antibodies in this vulnerable age group. They also show how our vaccines can increase the potency and coverage of existing therapies."

The need for a new vaccine approach that can stimulate a protective immune response in a greater proportion of people and a broader immune response that is capable of protecting against influenza strains not specifically matched to the strain(s) represented in the vaccine is even greater in the elderly population because they are most at risk for death and illnesses by influenza infection. In addition to improving the immune response and patient response rate against the matched seasonal strain in the older population, all patient serum samples will also be analyzed against other important H1N1 strains to assess the prime-boost regimen's ability to generate universal cross-strain protection and will be reported in 2013.

Inovio also reports that enrollment is complete for a phase II trial of a DNA vaccine for hepatitis C administered by Inovio's proprietary electroporation delivery technology. Researchers are currently analyzing levels of immune response and HCV viral load in trial subjects. Inovio will report preliminary results in the first quarter of 2013. The trial is being conducted by Inovio's partner, ChronTech Pharma AB.

About SynCon® Influenza Vaccines and this Clinical Trial Design

The strategy to combine an influenza DNA vaccine prime with a conventional seasonal vaccine boost is based on the idea that combining the different modalities of Inovio's SynCon® flu vaccine's ability to generate cross-protective antibody respon
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SOURCE Inovio Pharmaceuticals, Inc.
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